Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TRIM33

Summary for TRIM33

Gene information	Gene symbol	TRIM33
	Ensembl ID	ENSG00000197323
	Entrez ID	51592
	Gene name	tripartite motif containing 33
	Synonyms	FLJ11429\|KIAA1113\|PTC7\|RFG7\|TF1G\|TIF1G\|TIF1GAMMA\|TIFGAMMA
	Gene type	protein_coding
	UniProtAcc	Q9UPN9

Top

Dataset with differentially expressed gene: TRIM33

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.313645	2.29e-23
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.251212	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.253516	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.326864	0.00e+00

Top

Expression of TRIM33 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to TRIM33

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating TRIM33

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TRIM33	hsa-miR-1252-3p	99.55	NM_015906
TRIM33	hsa-miR-4775	99.2355	NM_015906
TRIM33	hsa-miR-3662	99.0435	NM_015906
TRIM33	hsa-miR-3658	99.0413	NM_015906
TRIM33	hsa-miR-19a-3p	99.0113	NM_015906
TRIM33	hsa-miR-19b-3p	99.0113	NM_015906
TRIM33	hsa-miR-629-5p	98.7519	NM_015906
TRIM33	hsa-miR-429	98.1771	NM_015906
TRIM33	hsa-miR-7849-3p	98.0559	NM_015906
TRIM33	hsa-miR-552-5p	97.8501	NM_015906
TRIM33	hsa-miR-200c-3p	97.5922	NM_015906
TRIM33	hsa-miR-200b-3p	97.5922	NM_015906
TRIM33	hsa-miR-6507-5p	97.5556	NM_015906
TRIM33	hsa-miR-8077	97.2142	NM_015906
TRIM33	hsa-miR-576-5p	97.1485	NM_015906
TRIM33	hsa-miR-3064-3p	96.9467	NM_015906
TRIM33	hsa-miR-1303	96.1468	NM_015906
TRIM33	hsa-miR-5582-3p	96.1289	NM_015906
TRIM33	hsa-miR-4662a-3p	96.0031	NM_015906
TRIM33	hsa-miR-4719	95.9305	NM_015906
TRIM33	hsa-miR-4699-3p	95.4331	NM_015906
TRIM33	hsa-miR-892a	95.3361	NM_015906
TRIM33	hsa-miR-4717-5p	95.3356	NM_015906
TRIM33	hsa-miR-7160-5p	95.1623	NM_015906
TRIM33	hsa-miR-5002-5p	95.1505	NM_015906
TRIM33	hsa-miR-4291	94.8427	NM_015906
TRIM33	hsa-miR-205-3p	94.668	NM_015906
TRIM33	hsa-miR-338-3p	94.5951	NM_015906
TRIM33	hsa-miR-590-3p	94.2693	NM_015906
TRIM33	hsa-miR-548c-3p	94.2487	NM_015906
TRIM33	hsa-miR-548x-3p	93.9549	NM_015906
TRIM33	hsa-miR-548aj-3p	93.9549	NM_015906
TRIM33	hsa-miR-3912-5p	93.5621	NM_015906
TRIM33	hsa-miR-5692a	93.5193	NM_015906
TRIM33	hsa-miR-6869-5p	93.3636	NM_015906
TRIM33	hsa-miR-922	93.2036	NM_015906
TRIM33	hsa-miR-153-5p	93.1627	NM_015906
TRIM33	hsa-miR-15b-3p	92.9398	NM_015906
TRIM33	hsa-miR-5689	92.6665	NM_015906
TRIM33	hsa-miR-548ae-3p	92.6294	NM_015906
TRIM33	hsa-miR-548j-3p	92.6294	NM_015906
TRIM33	hsa-miR-548aq-3p	92.6294	NM_015906
TRIM33	hsa-miR-548ah-3p	92.6294	NM_015906
TRIM33	hsa-miR-548am-3p	92.6294	NM_015906
TRIM33	hsa-miR-3609	92.4578	NM_015906
TRIM33	hsa-miR-548ah-5p	92.4162	NM_015906
TRIM33	hsa-miR-4735-5p	92.3768	NM_015906
TRIM33	hsa-miR-586	92.3684	NM_015906
TRIM33	hsa-miR-3646	92.1845	NM_015906
TRIM33	hsa-miR-1279	92.0591	NM_015906

Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating TRIM33

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TRIM33	metacluster_151.2	ZNF23 (directAnnotation).
TRIM33	transfac_pro__M05479	ZNF580 (directAnnotation).
TRIM33	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TRIM33	hdpi__ETV4	ETV4 (directAnnotation).
TRIM33	transfac_pro__M06071	ZNF814 (directAnnotation).
TRIM33	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
TRIM33	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TRIM33	transfac_pro__M04826	EP300 (directAnnotation).
TRIM33	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
TRIM33	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
TRIM33	transfac_pro__M04950	EGR1 (directAnnotation).
TRIM33	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
TRIM33	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
TRIM33	transfac_pro__M00652	NRF1 (directAnnotation).
TRIM33	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
TRIM33	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
TRIM33	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
TRIM33	transfac_pro__M04918	EGR1 (directAnnotation).
TRIM33	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
TRIM33	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
TRIM33	transfac_pro__M01122	ZNF219 (directAnnotation).
TRIM33	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TRIM33	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
TRIM33	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TRIM33	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
TRIM33	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TRIM33	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
TRIM33	jaspar__MA1721.1	ZNF93 (directAnnotation).
TRIM33	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
TRIM33	transfac_pro__M01199	TRIM28 (directAnnotation).
TRIM33	tfdimers__MD00391	KLF4 (directAnnotation).
TRIM33	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
TRIM33	cisbp__M00968	MTF2 (directAnnotation).
TRIM33	transfac_pro__M12697	ZNF142 (directAnnotation).
TRIM33	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TRIM33	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
TRIM33	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
TRIM33	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."