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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TRIM2

Summary for TRIM2

Gene information	Gene symbol	TRIM2
	Ensembl ID	ENSG00000109654
	Entrez ID	23321
	Gene name	tripartite motif containing 2
	Synonyms	CMT2R\|KIAA0517\|RNF86
	Gene type	protein_coding
	UniProtAcc	Q9C040

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Dataset with differentially expressed gene: TRIM2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.876329	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.368505	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.932548	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.456968	0.00e+00

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Expression of TRIM2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TRIM2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TRIM2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TRIM2	hsa-miR-5011-5p	99.9938	NM_015271
TRIM2	hsa-miR-4262	99.7184	NM_015271
TRIM2	hsa-miR-181a-5p	99.5029	NM_015271
TRIM2	hsa-miR-181b-5p	99.5029	NM_015271
TRIM2	hsa-miR-181d-5p	99.5029	NM_015271
TRIM2	hsa-miR-181c-5p	99.5029	NM_015271
TRIM2	hsa-miR-4696	99.4794	NM_015271
TRIM2	hsa-miR-2113	98.7575	NM_015271
TRIM2	hsa-miR-5195-3p	98.6335	NM_015271
TRIM2	hsa-miR-145-5p	98.6335	NM_015271
TRIM2	hsa-miR-153-5p	97.821	NM_015271
TRIM2	hsa-miR-1284	97.2929	NM_015271
TRIM2	hsa-miR-651-3p	96.9733	NM_015271
TRIM2	hsa-miR-10527-5p	96.8428	NM_015271
TRIM2	hsa-miR-190a-3p	96.813	NM_015271
TRIM2	hsa-miR-7856-5p	95.9221	NM_015271
TRIM2	hsa-miR-340-5p	95.7156	NM_015271
TRIM2	hsa-miR-559	95.2338	NM_015271
TRIM2	hsa-miR-548p	95.0999	NM_015271
TRIM2	hsa-miR-330-3p	95.069	NM_015271
TRIM2	hsa-miR-4422	95.0652	NM_015271
TRIM2	hsa-miR-3133	94.9755	NM_015271
TRIM2	hsa-miR-548y	94.9457	NM_015271
TRIM2	hsa-miR-548ak	94.9457	NM_015271
TRIM2	hsa-miR-548ab	94.9457	NM_015271
TRIM2	hsa-miR-548w	94.9457	NM_015271
TRIM2	hsa-miR-548au-5p	94.9457	NM_015271
TRIM2	hsa-miR-548a-5p	94.9457	NM_015271
TRIM2	hsa-miR-548ar-5p	94.9457	NM_015271
TRIM2	hsa-miR-548am-5p	94.9457	NM_015271
TRIM2	hsa-miR-548ad-5p	94.9457	NM_015271
TRIM2	hsa-miR-548j-5p	94.9457	NM_015271
TRIM2	hsa-miR-548i	94.9457	NM_015271
TRIM2	hsa-miR-548h-5p	94.9457	NM_015271
TRIM2	hsa-miR-548b-5p	94.9457	NM_015271
TRIM2	hsa-miR-548ay-5p	94.9457	NM_015271
TRIM2	hsa-miR-548d-5p	94.9457	NM_015271
TRIM2	hsa-miR-548c-5p	94.9457	NM_015271
TRIM2	hsa-miR-548ap-5p	94.9457	NM_015271
TRIM2	hsa-miR-548ae-5p	94.9457	NM_015271
TRIM2	hsa-miR-548bb-5p	94.9457	NM_015271
TRIM2	hsa-miR-548aq-5p	94.9457	NM_015271
TRIM2	hsa-miR-548as-5p	94.9457	NM_015271
TRIM2	hsa-miR-548o-5p	94.9457	NM_015271
TRIM2	hsa-miR-561-3p	94.7301	NM_015271
TRIM2	hsa-miR-548aw	93.9208	NM_015271
TRIM2	hsa-miR-3613-3p	93.3266	NM_015271
TRIM2	hsa-miR-5696	92.5573	NM_015271
TRIM2	hsa-miR-6867-5p	92.4245	NM_015271
TRIM2	hsa-miR-33a-3p	91.4026	NM_015271

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Motifs and transcription factors (TFs) regulating TRIM2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TRIM2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
TRIM2	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
TRIM2	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
TRIM2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
TRIM2	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
TRIM2	cisbp__M08198	ELF1 (directAnnotation).
TRIM2	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
TRIM2	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
TRIM2	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
TRIM2	transfac_pro__M01299	MECP2 (directAnnotation).
TRIM2	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
TRIM2	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
TRIM2	metacluster_52.11	ZNF184 (directAnnotation).
TRIM2	transfac_pro__M05976	ZNF223 (directAnnotation).
TRIM2	transfac_pro__M04913	ZBTB7A (directAnnotation).
TRIM2	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."