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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: TRIM13

Summary for TRIM13

Gene information	Gene symbol	TRIM13
	Ensembl ID	ENSG00000204977
	Entrez ID	10206
	Gene name	tripartite motif containing 13
	Synonyms	DLEU5\|Leu5\|RFP2\|RNF77
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TRIM13

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.253772	0.00e+00

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Expression of TRIM13 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TRIM13

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TRIM13

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TRIM13	hsa-miR-5011-5p	100	NM_001007278
TRIM13	hsa-miR-190a-3p	100	NM_001007278
TRIM13	hsa-miR-6867-5p	99.6298	NM_001007278
TRIM13	hsa-miR-3613-3p	99.0356	NM_001007278
TRIM13	hsa-miR-371b-5p	98.6234	NM_001007278
TRIM13	hsa-miR-616-5p	98.6234	NM_001007278
TRIM13	hsa-miR-373-5p	98.6234	NM_001007278
TRIM13	hsa-miR-4766-5p	95.0379	NM_001007278
TRIM13	hsa-miR-548ba	94.7461	NM_001007278
TRIM13	hsa-miR-570-5p	94.1948	NM_001007278
TRIM13	hsa-miR-548ag	94.1948	NM_001007278
TRIM13	hsa-miR-548ai	94.1948	NM_001007278
TRIM13	hsa-miR-1283	93.7001	NM_001007278
TRIM13	hsa-miR-30d-5p	92.4747	NM_001007278
TRIM13	hsa-miR-30a-5p	92.4747	NM_001007278
TRIM13	hsa-miR-30c-5p	92.4747	NM_001007278
TRIM13	hsa-miR-30e-5p	92.4747	NM_001007278
TRIM13	hsa-miR-30b-5p	92.4747	NM_001007278
TRIM13	hsa-miR-548c-3p	91.3717	NM_001007278
TRIM13	hsa-miR-1279	90.3794	NM_001007278
TRIM13	hsa-miR-6760-3p	88.2413	NM_001007278
TRIM13	hsa-miR-3143	87.5449	NM_001007278
TRIM13	hsa-miR-7161-5p	86.6083	NM_001007278
TRIM13	hsa-miR-130a-5p	85.6305	NM_001007278
TRIM13	hsa-miR-5590-3p	83.6419	NM_001007278
TRIM13	hsa-miR-142-5p	83.6419	NM_001007278
TRIM13	hsa-miR-302c-5p	83.041	NM_001007278
TRIM13	hsa-miR-548ah-5p	83.0045	NM_001007278
TRIM13	hsa-miR-3609	83.0004	NM_001007278
TRIM13	hsa-miR-520g-3p	82.2429	NM_001007278
TRIM13	hsa-miR-520h	82.2429	NM_001007278
TRIM13	hsa-miR-548u	81.3526	NM_001007278
TRIM13	hsa-miR-561-3p	80.4326	NM_001007278
TRIM13	hsa-let-7f-2-3p	80.0326	NM_001007278
TRIM13	hsa-miR-1185-1-3p	80.0326	NM_001007278
TRIM13	hsa-miR-1185-2-3p	80.0326	NM_001007278

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Motifs and transcription factors (TFs) regulating TRIM13

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TRIM13	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TRIM13	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TRIM13	transfac_pro__M07397	ZNF148 (directAnnotation).
TRIM13	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
TRIM13	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
TRIM13	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
TRIM13	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TRIM13	metacluster_7.13	ZFX (directAnnotation).
TRIM13	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
TRIM13	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
TRIM13	transfac_pro__M01175	ZBTB7B (directAnnotation).
TRIM13	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TRIM13	tfdimers__MD00151	CHURC1 (directAnnotation).
TRIM13	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
TRIM13	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
TRIM13	transfac_pro__M01303	SP1 (directAnnotation).
TRIM13	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TRIM13	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TRIM13	transfac_pro__M02090	E2F4 (directAnnotation).
TRIM13	transfac_pro__M01714	KLF15 (directAnnotation).
TRIM13	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
TRIM13	jaspar__MA1122.1	TFDP1 (directAnnotation).
TRIM13	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
TRIM13	transfac_pro__M02089	E2F3 (directAnnotation).
TRIM13	metacluster_3.14	WT1; WT1 (directAnnotation).
TRIM13	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
TRIM13	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
TRIM13	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
TRIM13	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
TRIM13	cisbp__M07938	E2F1 (directAnnotation).
TRIM13	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
TRIM13	transfac_pro__M07436	WT1 (directAnnotation).
TRIM13	transfac_pro__M02281	SP1 (directAnnotation).
TRIM13	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
TRIM13	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TRIM13	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
TRIM13	transfac_pro__M02898	SMAD3 (directAnnotation).
TRIM13	transfac_public__M00491	PATZ1 (directAnnotation).
TRIM13	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
TRIM13	"Dihydromorphine"	DB01565	small molecule
TRIM13	"Diprenorphine"	DB01548	small molecule
TRIM13	"Etorphine"	DB01497	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."