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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TRIB1

Summary for TRIB1

Gene information	Gene symbol	TRIB1
	Ensembl ID	ENSG00000173334
	Entrez ID	10221
	Gene name	tribbles pseudokinase 1
	Synonyms	C8FW\|GIG2\|TRB1
	Gene type	protein_coding
	UniProtAcc	Q96RU8

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Dataset with differentially expressed gene: TRIB1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.799947	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Plasma cells	0.377573	2.15e-05
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	0.522659	7.22e-09
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Plasma cells	0.379576	7.62e-36
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.356477	6.86e-21
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Plasma cells	0.579403	6.84e-07
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.755456	2.54e-41
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.530559	9.31e-07
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.396626	9.49e-20
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	pre	Malignant cells	-0.271357	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.463686	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.337122	1.59e-14
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.361773	8.60e-22
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.352655	1.89e-17
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.274244	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.836696	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	1.74245	0.00e+00

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Expression of TRIB1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TRIB1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TRIB1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TRIB1	hsa-miR-129-1-3p	95.7611	NM_001282985
TRIB1	hsa-miR-129-2-3p	95.7611	NM_001282985
TRIB1	hsa-miR-144-3p	95.7525	NM_001282985
TRIB1	hsa-miR-23a-3p	94.4684	NM_001282985
TRIB1	hsa-miR-23c	94.4684	NM_001282985
TRIB1	hsa-miR-23b-3p	94.4684	NM_001282985
TRIB1	hsa-miR-202-3p	94.0277	NM_001282985
TRIB1	hsa-miR-888-5p	93.8177	NM_001282985
TRIB1	hsa-miR-938	93.5256	NM_001282985
TRIB1	hsa-miR-6882-5p	89.1859	NM_001282985
TRIB1	hsa-miR-520b-5p	89.1769	NM_001282985
TRIB1	hsa-miR-519a-2-5p	89.1769	NM_001282985
TRIB1	hsa-miR-4671-3p	89.0005	NM_001282985
TRIB1	hsa-miR-4713-5p	88.429	NM_001282985
TRIB1	hsa-miR-1304-3p	88.1209	NM_001282985
TRIB1	hsa-miR-4530	85.2097	NM_001282985
TRIB1	hsa-miR-629-3p	84.0809	NM_001282985
TRIB1	hsa-miR-4290	83.7889	NM_001282985
TRIB1	hsa-miR-1324	83.276	NM_001282985
TRIB1	hsa-miR-331-5p	83.0643	NM_001282985
TRIB1	hsa-miR-4500	82.6267	NM_001282985
TRIB1	hsa-miR-6779-3p	80.3831	NM_001282985
TRIB1	hsa-miR-4687-5p	80.3831	NM_001282985
TRIB1	hsa-miR-4756-3p	80.3189	NM_001282985

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Motifs and transcription factors (TFs) regulating TRIB1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TRIB1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
TRIB1	transfac_pro__M06071	ZNF814 (directAnnotation).
TRIB1	transfac_public__M00039	CREB1 (directAnnotation).
TRIB1	cisbp__M04023	CREB1 (directAnnotation).
TRIB1	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
TRIB1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
TRIB1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
TRIB1	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
TRIB1	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
TRIB1	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
TRIB1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
TRIB1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
TRIB1	transfac_pro__M05804	ZBTB41 (inferredBy_Orthology).
TRIB1	transfac_pro__M06259	ZNF91 (directAnnotation).
TRIB1	taipale_tf_pairs__GCM1_CEBPB_ATRSGGGNNNNTTRCGYAAN_CAP_repr	CEBPB; GCM1 (directAnnotation).
TRIB1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
TRIB1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
TRIB1	c2h2_zfs__M0401	ZNF410 (inferredBy_Orthology).
TRIB1	taipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_meth	CDX2 (directAnnotation).
TRIB1	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
TRIB1	transfac_pro__M07436	WT1 (directAnnotation).
TRIB1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TRIB1	transfac_pro__M01118	WT1 (directAnnotation).
TRIB1	transfac_pro__M00807	EGR1; EGR2; EGR3 (directAnnotation).
TRIB1	kznf__CTCF_Rhee2011.2_ChIP-exo	CTCF (directAnnotation).
TRIB1	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
TRIB1	metacluster_111.5	E4F1; E4F1 (directAnnotation).
TRIB1	jaspar__MA1721.1	ZNF93 (directAnnotation).
TRIB1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
TRIB1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TRIB1	transfac_pro__M12697	ZNF142 (directAnnotation).
TRIB1	transfac_pro__M04916	TAF1 (directAnnotation).
TRIB1	metacluster_198.3	ZFP64 (directAnnotation).
TRIB1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TRIB1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TRIB1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
TRIB1	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
TRIB1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
TRIB1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
TRIB1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
TRIB1	transfac_pro__M01239	RELA (directAnnotation).
TRIB1	metacluster_46.4	CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; DBP; DBP; EP300; GATAD2A; HES2 (directAnnotation). CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; HLF; HLF (inferredBy_Orthology).
TRIB1	tfdimers__MD00352	ILF2; MYCN; NFATC2 (directAnnotation).
TRIB1	metacluster_27.12	ZNF274 (directAnnotation).
TRIB1	transfac_pro__M03858	TCF7L1 (directAnnotation).
TRIB1	tfdimers__MD00421	ELF3; POU5F1 (directAnnotation).
TRIB1	metacluster_22.15	BACH1 (directAnnotation).
TRIB1	transfac_pro__M01834	HOXD9 (directAnnotation).
TRIB1	taipale_tf_pairs__HOXB13_EOMES_NNMRTAAANTMACACNN_CAP_repr	EOMES; HOXB13 (directAnnotation).
TRIB1	metacluster_22.14	BACH1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."