Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TRIAP1

Summary for TRIAP1

Gene information	Gene symbol	TRIAP1
	Ensembl ID	ENSG00000170855
	Entrez ID	51499
	Gene name	TP53 regulated inhibitor of apoptosis 1
	Synonyms	HSPC132\|MDM35\|P53CSV\|WF-1
	Gene type	protein_coding
	UniProtAcc	O43715

Top

Dataset with differentially expressed gene: TRIAP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.453367	1.02e-29
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.649877	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.282113	4.09e-14
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.363588	3.07e-14
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.467648	1.77e-31
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.350367	1.61e-13
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.519104	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.418706	0.00e+00

Top

Expression of TRIAP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to TRIAP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating TRIAP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TRIAP1	hsa-miR-107	98.2437	NM_016399
TRIAP1	hsa-miR-103a-3p	98.2437	NM_016399
TRIAP1	hsa-miR-6761-5p	95.5127	NM_016399
TRIAP1	hsa-miR-10399-5p	92.7342	NM_016399
TRIAP1	hsa-miR-6504-3p	92.6052	NM_016399
TRIAP1	hsa-miR-624-3p	90.8308	NM_016399
TRIAP1	hsa-miR-4429	90.5206	NM_016399
TRIAP1	hsa-miR-320c	90.5206	NM_016399
TRIAP1	hsa-miR-320a-3p	90.5206	NM_016399
TRIAP1	hsa-miR-320d	90.5206	NM_016399
TRIAP1	hsa-miR-320b	90.5206	NM_016399
TRIAP1	hsa-miR-125a-5p	90.011	NM_016399
TRIAP1	hsa-miR-4319	90.011	NM_016399
TRIAP1	hsa-miR-125b-5p	90.011	NM_016399
TRIAP1	hsa-miR-616-5p	89.7623	NM_016399
TRIAP1	hsa-miR-373-5p	89.7623	NM_016399
TRIAP1	hsa-miR-371b-5p	89.7623	NM_016399
TRIAP1	hsa-miR-6721-5p	89.2522	NM_016399
TRIAP1	hsa-miR-1282	88.0403	NM_016399
TRIAP1	hsa-miR-6501-3p	87.7566	NM_016399
TRIAP1	hsa-miR-3125	84.5226	NM_016399
TRIAP1	hsa-miR-3916	84.5226	NM_016399
TRIAP1	hsa-miR-3613-3p	84.4478	NM_016399
TRIAP1	hsa-miR-216a-5p	83.0121	NM_016399
TRIAP1	hsa-miR-766-5p	82.2803	NM_016399
TRIAP1	hsa-miR-3665	82.0752	NM_016399
TRIAP1	hsa-miR-378a-5p	80.7902	NM_016399

Page: 1

Top

Motifs and transcription factors (TFs) regulating TRIAP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TRIAP1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
TRIAP1	metacluster_81.7	CREB1 (directAnnotation).
TRIAP1	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."