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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TRAPPC10

Summary for TRAPPC10

Gene information	Gene symbol	TRAPPC10
	Ensembl ID	ENSG00000160218
	Entrez ID	7109
	Gene name	trafficking protein particle complex subunit 10
	Synonyms	EHOC-1\|TMEM1\|TRS130
	Gene type	protein_coding
	UniProtAcc	P48553

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Dataset with differentially expressed gene: TRAPPC10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.257779	1.94e-19
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.254717	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.593099	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.41231	0.00e+00

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Expression of TRAPPC10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TRAPPC10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TRAPPC10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TRAPPC10	hsa-miR-374c-5p	98.7177	NM_003274
TRAPPC10	hsa-miR-655-3p	98.7177	NM_003274
TRAPPC10	hsa-miR-548x-5p	95.6206	NM_003274
TRAPPC10	hsa-miR-548aj-5p	95.6206	NM_003274
TRAPPC10	hsa-miR-548g-5p	95.6206	NM_003274
TRAPPC10	hsa-miR-548f-5p	95.6206	NM_003274
TRAPPC10	hsa-miR-223-5p	92.9244	NM_003274
TRAPPC10	hsa-miR-1250-3p	92.4033	NM_003274
TRAPPC10	hsa-miR-3133	92.3384	NM_003274
TRAPPC10	hsa-miR-3171	91.4126	NM_003274
TRAPPC10	hsa-miR-6499-3p	90.5035	NM_003274
TRAPPC10	hsa-miR-4282	89.2571	NM_003274
TRAPPC10	hsa-miR-3692-3p	88.8769	NM_003274
TRAPPC10	hsa-miR-3942-3p	88.073	NM_003274
TRAPPC10	hsa-miR-7154-5p	86.2903	NM_003274
TRAPPC10	hsa-miR-513b-5p	84.4609	NM_003274
TRAPPC10	hsa-miR-891b	84.337	NM_003274
TRAPPC10	hsa-miR-8087	84.1496	NM_003274
TRAPPC10	hsa-miR-551b-5p	83.3332	NM_003274
TRAPPC10	hsa-miR-4278	82.7469	NM_003274
TRAPPC10	hsa-miR-4517	81.7268	NM_003274
TRAPPC10	hsa-miR-5582-3p	80.7017	NM_003274

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Motifs and transcription factors (TFs) regulating TRAPPC10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TRAPPC10	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
TRAPPC10	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
TRAPPC10	transfac_pro__M04918	EGR1 (directAnnotation).
TRAPPC10	metacluster_7.13	ZFX (directAnnotation).
TRAPPC10	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TRAPPC10	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
TRAPPC10	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TRAPPC10	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TRAPPC10	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TRAPPC10	cisbp__M01863	ZNF711 (inferredBy_Orthology).
TRAPPC10	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
TRAPPC10	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TRAPPC10	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
TRAPPC10	cisbp__M00788	ZFY (inferredBy_Orthology).
TRAPPC10	hdpi__HIP2	UBE2K (directAnnotation).
TRAPPC10	transfac_pro__M02913	SP140 (inferredBy_Orthology).
TRAPPC10	transfac_pro__M02898	SMAD3 (directAnnotation).
TRAPPC10	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TRAPPC10	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
TRAPPC10	transfac_pro__M04893	TAF1 (directAnnotation).
TRAPPC10	transfac_pro__M00430	E2F1 (directAnnotation).
TRAPPC10	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
TRAPPC10	hdpi__ZNF304	ZNF304 (directAnnotation).
TRAPPC10	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
TRAPPC10	transfac_pro__M00938	E2F1 (directAnnotation).
TRAPPC10	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
TRAPPC10	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TRAPPC10	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
TRAPPC10	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
TRAPPC10	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TRAPPC10	transfac_pro__M01199	TRIM28 (directAnnotation).
TRAPPC10	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
TRAPPC10	hdpi__ELF2	ELF2 (directAnnotation).
TRAPPC10	tfdimers__MD00038	TFAP2C (directAnnotation).
TRAPPC10	metacluster_198.3	ZFP64 (directAnnotation).
TRAPPC10	cisbp__M00968	MTF2 (directAnnotation).
TRAPPC10	transfac_pro__M00716	ZBTB14 (directAnnotation).
TRAPPC10	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
TRAPPC10	transfac_pro__M04916	TAF1 (directAnnotation).
TRAPPC10	transfac_pro__M02089	E2F3 (directAnnotation).
TRAPPC10	transfac_pro__M04817	ZBTB33 (directAnnotation).
TRAPPC10	transfac_pro__M07310	SP5 (directAnnotation).
TRAPPC10	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
TRAPPC10	hdpi__NRL	NRL (directAnnotation).
TRAPPC10	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
TRAPPC10	transfac_pro__M07387	ZBTB7A (directAnnotation).
TRAPPC10	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
TRAPPC10	transfac_pro__M01783	SP2 (directAnnotation).
TRAPPC10	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
TRAPPC10	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."