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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TRAM2

Summary for TRAM2

Gene information	Gene symbol	TRAM2
	Ensembl ID	ENSG00000065308
	Entrez ID	9697
	Gene name	translocation associated membrane protein 2
	Synonyms	KIAA0057
	Gene type	protein_coding
	UniProtAcc	Q15035

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Dataset with differentially expressed gene: TRAM2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.609946	0.00e+00

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Expression of TRAM2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TRAM2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TRAM2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TRAM2	hsa-miR-133b	97.696	NM_012288
TRAM2	hsa-miR-133a-3p	97.696	NM_012288
TRAM2	hsa-miR-6832-3p	95.0095	NM_012288
TRAM2	hsa-miR-6887-3p	94.8699	NM_012288
TRAM2	hsa-miR-580-3p	91.4115	NM_012288
TRAM2	hsa-miR-3065-3p	90.2409	NM_012288
TRAM2	hsa-miR-1324	88.6567	NM_012288
TRAM2	hsa-miR-4656	88.5873	NM_012288
TRAM2	hsa-miR-4772-3p	87.9487	NM_012288
TRAM2	hsa-miR-7111-5p	87.8251	NM_012288
TRAM2	hsa-miR-5004-5p	87.6153	NM_012288
TRAM2	hsa-miR-4747-5p	86.9459	NM_012288
TRAM2	hsa-miR-193b-5p	86.2479	NM_012288
TRAM2	hsa-miR-4723-5p	86.245	NM_012288
TRAM2	hsa-miR-5698	86.245	NM_012288
TRAM2	hsa-miR-6870-5p	86.245	NM_012288
TRAM2	hsa-miR-5196-5p	85.9565	NM_012288
TRAM2	hsa-miR-4492	85.5671	NM_012288
TRAM2	hsa-miR-124-3p	85.3451	NM_012288
TRAM2	hsa-miR-506-3p	85.3451	NM_012288
TRAM2	hsa-miR-653-5p	85.1669	NM_012288
TRAM2	hsa-miR-548g-3p	84.6741	NM_012288
TRAM2	hsa-miR-5001-3p	84.3816	NM_012288
TRAM2	hsa-miR-3190-3p	84.3063	NM_012288
TRAM2	hsa-miR-205-3p	84.0748	NM_012288
TRAM2	hsa-miR-4422	83.0692	NM_012288
TRAM2	hsa-miR-548c-3p	82.6775	NM_012288
TRAM2	hsa-miR-6878-5p	81.9446	NM_012288
TRAM2	hsa-miR-4298	81.8266	NM_012288
TRAM2	hsa-miR-548ar-3p	81.7575	NM_012288
TRAM2	hsa-miR-6738-3p	81.7423	NM_012288
TRAM2	hsa-miR-676-5p	80.8001	NM_012288
TRAM2	hsa-miR-7111-3p	80.7533	NM_012288
TRAM2	hsa-miR-6847-5p	80.6136	NM_012288
TRAM2	hsa-miR-4731-5p	80.1193	NM_012288

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Motifs and transcription factors (TFs) regulating TRAM2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TRAM2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
TRAM2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
TRAM2	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
TRAM2	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
TRAM2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
TRAM2	hdpi__ETV4	ETV4 (directAnnotation).
TRAM2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TRAM2	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
TRAM2	metacluster_182.10	ZFX (directAnnotation).
TRAM2	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."