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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TRAK2

Summary for TRAK2

Gene information	Gene symbol	TRAK2
	Ensembl ID	ENSG00000115993
	Entrez ID	66008
	Gene name	trafficking kinesin protein 2
	Synonyms	ALS2CR3\|CALS-C\|GRIF-1\|KIAA0549\|MILT2\|OIP98
	Gene type	protein_coding
	UniProtAcc	O60296

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Dataset with differentially expressed gene: TRAK2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.256507	1.02e-04
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.574124	2.63e-22
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.303513	4.72e-21

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Expression of TRAK2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TRAK2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TRAK2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TRAK2	hsa-miR-12136	99.0056	NM_015049
TRAK2	hsa-miR-498-3p	97.5227	NM_015049
TRAK2	hsa-miR-3662	97.1727	NM_015049
TRAK2	hsa-miR-568	96.8743	NM_015049
TRAK2	hsa-miR-6833-3p	93.173	NM_015049
TRAK2	hsa-miR-892a	92.9486	NM_015049
TRAK2	hsa-miR-4303	92.8385	NM_015049
TRAK2	hsa-miR-5696	92.6965	NM_015049
TRAK2	hsa-miR-10393-3p	92.5417	NM_015049
TRAK2	hsa-miR-6801-5p	92.5417	NM_015049
TRAK2	hsa-miR-4768-5p	91.1496	NM_015049
TRAK2	hsa-miR-6781-3p	89.7781	NM_015049
TRAK2	hsa-miR-550a-5p	89.0533	NM_015049
TRAK2	hsa-miR-550a-3-5p	89.0533	NM_015049
TRAK2	hsa-miR-1271-3p	89.0533	NM_015049
TRAK2	hsa-miR-1197	88.5162	NM_015049
TRAK2	hsa-miR-2682-3p	88.4314	NM_015049
TRAK2	hsa-miR-12132	87.9145	NM_015049
TRAK2	hsa-miR-205-5p	86.8219	NM_015049
TRAK2	hsa-miR-651-3p	86.2955	NM_015049
TRAK2	hsa-miR-4324	85.9636	NM_015049
TRAK2	hsa-miR-627-3p	85.8784	NM_015049
TRAK2	hsa-miR-4797-3p	85.6715	NM_015049
TRAK2	hsa-miR-4729	84.2406	NM_015049
TRAK2	hsa-miR-6792-3p	84.0418	NM_015049
TRAK2	hsa-miR-570-3p	83.9552	NM_015049
TRAK2	hsa-miR-647	83.8893	NM_015049
TRAK2	hsa-miR-148a-3p	83.8323	NM_015049
TRAK2	hsa-miR-148b-3p	83.8323	NM_015049
TRAK2	hsa-miR-152-3p	83.8323	NM_015049
TRAK2	hsa-miR-211-3p	82.5446	NM_015049
TRAK2	hsa-miR-4726-3p	82.4149	NM_015049
TRAK2	hsa-miR-135a-3p	81.8687	NM_015049
TRAK2	hsa-miR-4251	81.6699	NM_015049
TRAK2	hsa-miR-664a-3p	81.4543	NM_015049
TRAK2	hsa-miR-2113	80.928	NM_015049
TRAK2	hsa-miR-4691-5p	80.8415	NM_015049
TRAK2	hsa-miR-4325	80.8179	NM_015049
TRAK2	hsa-miR-548c-3p	80.5182	NM_015049
TRAK2	hsa-miR-3160-5p	80.5015	NM_015049
TRAK2	hsa-miR-12119	80.2248	NM_015049

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Motifs and transcription factors (TFs) regulating TRAK2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TRAK2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
TRAK2	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
TRAK2	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
TRAK2	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
TRAK2	metacluster_101.3	MYB (directAnnotation).
TRAK2	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
TRAK2	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
TRAK2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
TRAK2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TRAK2	cisbp__M02645	ETS1 (directAnnotation).
TRAK2	hdpi__TIMELESS	TIMELESS (directAnnotation).
TRAK2	hdpi__ETV4	ETV4 (directAnnotation).
TRAK2	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
TRAK2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."