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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TPST2

Summary for TPST2

Gene information	Gene symbol	TPST2
	Ensembl ID	ENSG00000128294
	Entrez ID	8459
	Gene name	tyrosylprotein sulfotransferase 2
	Synonyms	TANGO13B
	Gene type	protein_coding
	UniProtAcc	O60704

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Dataset with differentially expressed gene: TPST2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	NK cells	-0.381045	1.44e-02
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	NK cells	0.268105	2.75e-21
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.670217	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	NK cells	-0.616538	2.92e-04
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.333883	0.00e+00

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Expression of TPST2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TPST2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TPST2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TPST2	hsa-miR-506-3p	91.8056	NM_001008566
TPST2	hsa-miR-124-3p	91.8056	NM_001008566
TPST2	hsa-miR-4452	91.5315	NM_001008566
TPST2	hsa-miR-5582-5p	91.1741	NM_001008566
TPST2	hsa-miR-6831-5p	89.1913	NM_001008566
TPST2	hsa-miR-8053	89.1662	NM_001008566
TPST2	hsa-miR-3121-3p	87.0054	NM_001008566
TPST2	hsa-miR-6734-5p	86.7686	NM_001008566
TPST2	hsa-miR-12136	84.6271	NM_001008566
TPST2	hsa-miR-450b-5p	82.7121	NM_001008566
TPST2	hsa-miR-4436b-5p	80.987	NM_001008566

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Motifs and transcription factors (TFs) regulating TPST2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TPST2	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
TPST2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
TPST2	transfac_pro__M05927	ZNF408 (directAnnotation).
TPST2	transfac_pro__M00678	ETV7 (directAnnotation).
TPST2	transfac_pro__M06665	ZNF599 (directAnnotation).
TPST2	transfac_pro__M06313	ZNF678 (directAnnotation).
TPST2	tfdimers__MD00187	GATA1; GATA2; GATA3; GATA4; GATA5; GATA6 (directAnnotation).
TPST2	metacluster_27.20	ZNF708; ZNF787; ZNF787; ZNF85 (directAnnotation).
TPST2	homer__GAGSCCGAGC_ZNF519	ZNF519 (directAnnotation).
TPST2	tfdimers__MD00147	ELF5; TFAP2C (directAnnotation).
TPST2	transfac_pro__M05756	ZNF470 (directAnnotation).
TPST2	tfdimers__MD00165	CRX; FOS; FOSB; FOSL1; FOSL2; JUN; JUNB; JUND (directAnnotation).
TPST2	cisbp__M00212	SOX13 (inferredBy_Orthology).
TPST2	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
TPST2	swissregulon__hs__ELF2	ELF2 (directAnnotation).
TPST2	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
TPST2	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
TPST2	transfac_pro__M05542	SNAPC4 (directAnnotation).
TPST2	taipale_tf_pairs__ERF_TBX21_TMACACCGGAAG_CAP	ERF; TBX21 (directAnnotation).
TPST2	tfdimers__MD00259	HOXA13; MAFA (directAnnotation).
TPST2	metacluster_178.14	LHX6 (directAnnotation).
TPST2	tfdimers__MD00444	SIRT6; TFAP2C (directAnnotation).
TPST2	transfac_pro__M06234	ZNF91 (directAnnotation).
TPST2	transfac_pro__M05517	IKZF2 (directAnnotation).
TPST2	metacluster_74.8	HNF1B (directAnnotation).
TPST2	metacluster_181.2	GLIS1; GLIS3 (directAnnotation).
TPST2	transfac_pro__M06724	ZNF331 (directAnnotation).
TPST2	metacluster_65.12	ATF6 (directAnnotation).
TPST2	metacluster_74.13	HNF1A; HNF1B (directAnnotation).
TPST2	transfac_pro__M06132	ZNF823 (directAnnotation).
TPST2	homer__YTKGATAHAGTATTCTWGGTNGGCA_ZNF136	ZNF136 (directAnnotation).
TPST2	jaspar__MA1952.1	FOXJ2 (directAnnotation).
TPST2	transfac_pro__M06561	ZNF502 (directAnnotation).
TPST2	tfdimers__MD00002	CRX (directAnnotation).
TPST2	tfdimers__MD00169	TCF7L1; YY1 (directAnnotation).
TPST2	metacluster_25.2	LHX6; LHX6; LHX8 (directAnnotation).
TPST2	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
TPST2	transfac_pro__M06374	ZNF626 (directAnnotation).
TPST2	tfdimers__MD00111	CRX; PBX1 (directAnnotation).
TPST2	transfac_public__M00396	EN1 (directAnnotation).
TPST2	taipale_tf_pairs__HOXB2_PAX1_NNMATTAGTCACGCWTSRNTG_CAP_repr	HOXB2; PAX1 (directAnnotation).
TPST2	kznf__ZNF382_Najafabadi2015_ChIP-seq	ZNF382 (directAnnotation).
TPST2	metacluster_16.1	SOX9; ZIK1; ZIK1; ZNF782 (directAnnotation). SOX9 (inferredBy_Orthology).
TPST2	taipale_tf_pairs__HOXB2_SOX15_ACAAWRSNNNNYMATTA_CAP_repr	HOXB2; SOX15 (directAnnotation).
TPST2	metacluster_74.10	HNF1B (directAnnotation).
TPST2	transfac_pro__M01252	E2F6 (directAnnotation).
TPST2	metacluster_141.13	METTL14 (inferredBy_Orthology).
TPST2	tfdimers__MD00546	HOXC8; NFE2L1 (directAnnotation).
TPST2	metacluster_31.3	ZSCAN20; ZSCAN29 (directAnnotation).
TPST2	taipale_tf_pairs__HOXB13_ONECUT2_NNNRTAAAWATYGAYY_HT	HOXB13; ONECUT2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."