Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: TPR

Summary for TPR

Gene information	Gene symbol	TPR
	Ensembl ID	ENSG00000047410
	Entrez ID	7175
	Gene name	translocated promoter region, nuclear basket protein
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P12270

Top

Dataset with differentially expressed gene: TPR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.56647	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	-0.263714	4.73e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.257598	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.444722	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.273346	2.83e-43
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.286018	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.270868	2.40e-18
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.278792	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.38056	1.69e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.294217	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.819092	1.77e-03
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.394544	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.386394	0.00e+00

Top

Expression of TPR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to TPR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating TPR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TPR	hsa-miR-4477a	97.67	NM_003292
TPR	hsa-miR-186-5p	95.7482	NM_003292
TPR	hsa-miR-203a-3p	95.2486	NM_003292
TPR	hsa-miR-5195-3p	94.9658	NM_003292
TPR	hsa-miR-145-5p	94.9658	NM_003292
TPR	hsa-miR-190a-3p	94.7105	NM_003292
TPR	hsa-miR-579-3p	94.0941	NM_003292
TPR	hsa-miR-664b-3p	94.0941	NM_003292
TPR	hsa-miR-3133	93.8615	NM_003292
TPR	hsa-miR-5011-5p	93.2359	NM_003292
TPR	hsa-miR-27a-3p	93.2145	NM_003292
TPR	hsa-miR-27b-3p	93.2145	NM_003292
TPR	hsa-miR-9985	93.2145	NM_003292
TPR	hsa-miR-656-3p	92.7198	NM_003292
TPR	hsa-miR-4291	90.7535	NM_003292
TPR	hsa-miR-199a-5p	90.727	NM_003292
TPR	hsa-miR-199b-5p	90.727	NM_003292
TPR	hsa-miR-1236-3p	89.8604	NM_003292
TPR	hsa-miR-548ba	89.6545	NM_003292
TPR	hsa-miR-548ai	89.6545	NM_003292
TPR	hsa-miR-570-5p	89.6545	NM_003292
TPR	hsa-miR-548ag	89.6545	NM_003292
TPR	hsa-miR-12123	89.2935	NM_003292
TPR	hsa-miR-5696	88.8254	NM_003292
TPR	hsa-miR-548m	88.7776	NM_003292
TPR	hsa-miR-4276	88.0584	NM_003292
TPR	hsa-miR-4509	87.7831	NM_003292
TPR	hsa-miR-5680	86.433	NM_003292
TPR	hsa-miR-11399	86.342	NM_003292
TPR	hsa-miR-513a-5p	85.7587	NM_003292
TPR	hsa-miR-548a-3p	84.5406	NM_003292
TPR	hsa-miR-4670-3p	84.5076	NM_003292
TPR	hsa-miR-548e-3p	84.3423	NM_003292
TPR	hsa-miR-548f-3p	84.3423	NM_003292
TPR	hsa-miR-548bc	84.3423	NM_003292
TPR	hsa-miR-548az-3p	84.3423	NM_003292
TPR	hsa-miR-548ar-3p	84.3231	NM_003292
TPR	hsa-miR-96-5p	83.8499	NM_003292
TPR	hsa-miR-410-3p	83.1443	NM_003292
TPR	hsa-miR-4773	82.5269	NM_003292
TPR	hsa-miR-12133	81.5657	NM_003292
TPR	hsa-miR-1271-5p	81.5657	NM_003292
TPR	hsa-miR-874-3p	81.2789	NM_003292
TPR	hsa-miR-514b-3p	81.1425	NM_003292
TPR	hsa-miR-514a-3p	81.1425	NM_003292
TPR	hsa-miR-205-5p	80.9327	NM_003292
TPR	hsa-miR-510-3p	80.7544	NM_003292
TPR	hsa-miR-30e-3p	80.5866	NM_003292
TPR	hsa-miR-30a-3p	80.5866	NM_003292
TPR	hsa-miR-30d-3p	80.5866	NM_003292

Page: 1

Top

Motifs and transcription factors (TFs) regulating TPR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TPR	hdpi__ETV4	ETV4 (directAnnotation).
TPR	hdpi__TIMELESS	TIMELESS (directAnnotation).
TPR	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
TPR	jaspar__MA1483.2	ELF2 (directAnnotation).
TPR	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
TPR	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
TPR	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
TPR	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
TPR	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
TPR	taipale_tf_pairs__ERF_TBX21_TMACACCGGAAG_CAP	ERF; TBX21 (directAnnotation).
TPR	taipale_tf_pairs__HOXD12_ELK3_NTTTAYNNCCGGAARNN_CAP_repr	ELK3; HOXD12 (directAnnotation).
TPR	cisbp__M02645	ETS1 (directAnnotation).
TPR	jaspar__MA1935.1	FOXI1 (directAnnotation).
TPR	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
TPR	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
TPR	transfac_pro__M04944	GABPA (directAnnotation).
TPR	metacluster_183.4	ETS1 (inferredBy_Orthology).
TPR	swissregulon__hs__ELF2	ELF2 (directAnnotation).
TPR	transfac_pro__M05427	ZNF516 (directAnnotation).
TPR	cisbp__M00808	MYPOP (inferredBy_Orthology).
TPR	metacluster_172.6	CHD2; E2F1 (directAnnotation).
TPR	transfac_pro__M06055	ZNF99 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
TPR	"Flavin adenine dinucleotide"	DB03147	small molecule
TPR	"Maleic acid"	DB04299	small molecule
TPR	"Quinacrine mustard"	DB02240	small molecule
TPR	"Trypanothione"	DB03470	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."