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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TPBG

Summary for TPBG

Gene information	Gene symbol	TPBG
	Ensembl ID	ENSG00000283085
	Entrez ID	7162
	Gene name	trophoblast glycoprotein
	Synonyms	5T4\|5T4-AG
	Gene type	protein_coding
	UniProtAcc	Q13641

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Dataset with differentially expressed gene: TPBG

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.331974	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.978246	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.272191	1.37e-08

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Expression of TPBG in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TPBG

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TPBG

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TPBG	hsa-miR-589-3p	97.5244	NM_001166392
TPBG	hsa-miR-548ar-3p	97.2002	NM_001166392
TPBG	hsa-miR-548bc	95.9004	NM_001166392
TPBG	hsa-miR-548e-3p	95.9004	NM_001166392
TPBG	hsa-miR-548az-3p	95.9004	NM_001166392
TPBG	hsa-miR-548f-3p	95.9004	NM_001166392
TPBG	hsa-miR-548a-3p	95.8202	NM_001166392
TPBG	hsa-miR-4670-3p	91.9829	NM_001166392
TPBG	hsa-miR-548av-3p	91.7625	NM_001166392
TPBG	hsa-miR-1827	90.8878	NM_001166392
TPBG	hsa-miR-548g-3p	89.9702	NM_001166392
TPBG	hsa-miR-6083	89.6977	NM_001166392
TPBG	hsa-miR-12115	86.4041	NM_001166392
TPBG	hsa-miR-3145-3p	83.8122	NM_001166392
TPBG	hsa-miR-3613-3p	83.3091	NM_001166392
TPBG	hsa-miR-6787-3p	82.869	NM_001166392
TPBG	hsa-miR-545-5p	82.3477	NM_001166392
TPBG	hsa-miR-559	82.1746	NM_001166392
TPBG	hsa-miR-3658	81.7756	NM_001166392
TPBG	hsa-miR-1206	81.6883	NM_001166392
TPBG	hsa-miR-1205	81.5467	NM_001166392
TPBG	hsa-miR-10394-5p	81.5467	NM_001166392
TPBG	hsa-miR-6828-3p	80.672	NM_001166392
TPBG	hsa-miR-596	80.2542	NM_001166392

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Motifs and transcription factors (TFs) regulating TPBG

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TPBG	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TPBG	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TPBG	transfac_pro__M07397	ZNF148 (directAnnotation).
TPBG	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
TPBG	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
TPBG	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
TPBG	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TPBG	metacluster_7.13	ZFX (directAnnotation).
TPBG	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
TPBG	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
TPBG	transfac_pro__M01175	ZBTB7B (directAnnotation).
TPBG	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TPBG	tfdimers__MD00151	CHURC1 (directAnnotation).
TPBG	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
TPBG	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
TPBG	transfac_pro__M01303	SP1 (directAnnotation).
TPBG	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TPBG	transfac_pro__M02090	E2F4 (directAnnotation).
TPBG	transfac_pro__M01714	KLF15 (directAnnotation).
TPBG	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
TPBG	jaspar__MA1122.1	TFDP1 (directAnnotation).
TPBG	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
TPBG	transfac_pro__M02089	E2F3 (directAnnotation).
TPBG	transfac_pro__M12604	ZNF444 (directAnnotation).
TPBG	metacluster_3.14	WT1; WT1 (directAnnotation).
TPBG	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
TPBG	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
TPBG	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
TPBG	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
TPBG	cisbp__M07938	E2F1 (directAnnotation).
TPBG	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
TPBG	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
TPBG	transfac_pro__M07436	WT1 (directAnnotation).
TPBG	transfac_pro__M02281	SP1 (directAnnotation).
TPBG	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
TPBG	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TPBG	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
TPBG	transfac_pro__M02898	SMAD3 (directAnnotation).
TPBG	transfac_public__M00491	PATZ1 (directAnnotation).
TPBG	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
TPBG	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
TPBG	transfac_pro__M01299	MECP2 (directAnnotation).
TPBG	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
TPBG	jaspar__MA1596.1	ZNF460 (directAnnotation).
TPBG	metacluster_52.11	ZNF184 (directAnnotation).
TPBG	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
TPBG	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
TPBG	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
TPBG	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
TPBG	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."