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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TOR2A

Summary for TOR2A

Gene information	Gene symbol	TOR2A
	Ensembl ID	ENSG00000160404
	Entrez ID	27433
	Gene name	torsin family 2 member A
	Synonyms	FLJ14771\|TORP1
	Gene type	protein_coding
	UniProtAcc	Q8N2E6

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Dataset with differentially expressed gene: TOR2A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.306749	0.00e+00

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Expression of TOR2A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TOR2A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TOR2A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TOR2A	hsa-miR-10394-5p	95.0431	NM_001134431
TOR2A	hsa-miR-1205	95.0431	NM_001134431
TOR2A	hsa-miR-4682	94.6393	NM_001134431
TOR2A	hsa-miR-24-3p	92.6298	NM_130459
TOR2A	hsa-miR-4319	91.7423	NM_001134431
TOR2A	hsa-miR-125a-5p	90.9397	NM_001134431
TOR2A	hsa-miR-125b-5p	90.9397	NM_001134431
TOR2A	hsa-miR-27b-3p	89.4975	NM_001134431
TOR2A	hsa-miR-27a-3p	89.4975	NM_001134431
TOR2A	hsa-miR-9985	89.4975	NM_001134431
TOR2A	hsa-miR-12128	89.0004	NM_001134431
TOR2A	hsa-miR-765	85.5672	NM_001134431
TOR2A	hsa-miR-6770-5p	85.5102	NM_001134431
TOR2A	hsa-miR-1299	81.5714	NM_001252021
TOR2A	hsa-miR-6847-5p	81.0637	NM_001134431
TOR2A	hsa-miR-4695-5p	80.1783	NM_001134431
TOR2A	hsa-miR-4502	80.0419	NM_001134431

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Motifs and transcription factors (TFs) regulating TOR2A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TOR2A	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
TOR2A	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."