Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TOR1AIP2

Summary for TOR1AIP2

Gene information	Gene symbol	TOR1AIP2
	Ensembl ID	ENSG00000169905
	Entrez ID	163590
	Gene name	torsin 1A interacting protein 2
	Synonyms	IFRG15\|LULL1\|NET9
	Gene type	protein_coding
	UniProtAcc	Q8NFQ8

Top

Dataset with differentially expressed gene: TOR1AIP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.271695	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.32533	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.302914	1.40e-45
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.349807	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.389087	1.98e-19
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.341763	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.753192	0.00e+00

Top

Expression of TOR1AIP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to TOR1AIP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating TOR1AIP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TOR1AIP2	hsa-miR-153-5p	99.623	NM_001199260
TOR1AIP2	hsa-miR-373-5p	99.0213	NM_001199260
TOR1AIP2	hsa-miR-371b-5p	99.0213	NM_001199260
TOR1AIP2	hsa-miR-616-5p	99.0213	NM_001199260
TOR1AIP2	hsa-miR-3613-3p	98.0045	NM_001199260
TOR1AIP2	hsa-miR-7111-3p	96.9721	NM_001199260
TOR1AIP2	hsa-miR-4272	96.4792	NM_001199260
TOR1AIP2	hsa-miR-7-1-3p	95.8462	NM_001199260
TOR1AIP2	hsa-miR-7-2-3p	95.8462	NM_001199260
TOR1AIP2	hsa-miR-548e-5p	94.8942	NM_022347
TOR1AIP2	hsa-miR-1914-5p	94.5316	NM_001199260
TOR1AIP2	hsa-miR-1972	93.0553	NM_001199260
TOR1AIP2	hsa-miR-1185-1-3p	92.5475	NM_001199260
TOR1AIP2	hsa-miR-1185-2-3p	92.5475	NM_001199260
TOR1AIP2	hsa-miR-513c-3p	91.4604	NM_001199260
TOR1AIP2	hsa-miR-513a-3p	91.4604	NM_001199260
TOR1AIP2	hsa-miR-4637	90.7885	NM_022347
TOR1AIP2	hsa-miR-3529-3p	90.4647	NM_022347
TOR1AIP2	hsa-miR-1284	90.1825	NM_001199260
TOR1AIP2	hsa-miR-3606-3p	89.8138	NM_001199260
TOR1AIP2	hsa-miR-3202	89.4148	NM_001199260
TOR1AIP2	hsa-miR-590-3p	88.9557	NM_022347
TOR1AIP2	hsa-miR-302c-5p	88.7191	NM_001199260
TOR1AIP2	hsa-miR-3184-3p	88.2485	NM_022347
TOR1AIP2	hsa-miR-136-3p	88.114	NM_001199260
TOR1AIP2	hsa-miR-6071	88.0931	NM_001199260
TOR1AIP2	hsa-let-7f-2-3p	87.9838	NM_001199260
TOR1AIP2	hsa-miR-5680	87.761	NM_001199260
TOR1AIP2	hsa-miR-4307	87.5442	NM_001199260
TOR1AIP2	hsa-miR-4684-5p	87.2224	NM_022347
TOR1AIP2	hsa-miR-4760-5p	87.1624	NM_001199260
TOR1AIP2	hsa-miR-8061	86.8369	NM_001199260
TOR1AIP2	hsa-miR-519a-2-5p	85.4217	NM_022347
TOR1AIP2	hsa-miR-520b-5p	85.4217	NM_022347
TOR1AIP2	hsa-miR-4422	85.4003	NM_022347
TOR1AIP2	hsa-miR-1537-5p	85.3146	NM_001199260
TOR1AIP2	hsa-miR-188-3p	85.2387	NM_022347
TOR1AIP2	hsa-miR-133b	84.9938	NM_001199260
TOR1AIP2	hsa-miR-133a-3p	84.9938	NM_001199260
TOR1AIP2	hsa-miR-3168	84.9089	NM_022347
TOR1AIP2	hsa-miR-5003-5p	84.7553	NM_022347
TOR1AIP2	hsa-miR-3662	84.7198	NM_001199260
TOR1AIP2	hsa-miR-1250-3p	84.7029	NM_001199260
TOR1AIP2	hsa-miR-597-3p	84.6583	NM_001199260
TOR1AIP2	hsa-miR-3163	83.9478	NM_001199260
TOR1AIP2	hsa-miR-552-5p	83.7734	NM_001199260
TOR1AIP2	hsa-miR-939-3p	83.4082	NM_022347
TOR1AIP2	hsa-miR-548ax	83.1255	NM_001199260
TOR1AIP2	hsa-miR-548ao-5p	83.1255	NM_001199260
TOR1AIP2	hsa-miR-4503	83.0751	NM_022347

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating TOR1AIP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TOR1AIP2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
TOR1AIP2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
TOR1AIP2	jaspar__MA1122.1	TFDP1 (directAnnotation).
TOR1AIP2	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
TOR1AIP2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
TOR1AIP2	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
TOR1AIP2	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
TOR1AIP2	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
TOR1AIP2	jaspar__MA1933.1	SREBF2 (directAnnotation).
TOR1AIP2	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
TOR1AIP2	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
TOR1AIP2	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
TOR1AIP2	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
TOR1AIP2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
TOR1AIP2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TOR1AIP2	jaspar__MA1721.1	ZNF93 (directAnnotation).
TOR1AIP2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TOR1AIP2	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
TOR1AIP2	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
TOR1AIP2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
TOR1AIP2	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
TOR1AIP2	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
TOR1AIP2	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
TOR1AIP2	tfdimers__MD00364	WT1 (directAnnotation).
TOR1AIP2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
TOR1AIP2	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
TOR1AIP2	metacluster_144.13	HIC1; HIC1 (directAnnotation).
TOR1AIP2	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
TOR1AIP2	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
TOR1AIP2	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
TOR1AIP2	transfac_pro__M05791	ZNF517 (directAnnotation).
TOR1AIP2	hdpi__TP73	TP73 (directAnnotation).
TOR1AIP2	cisbp__M02645	ETS1 (directAnnotation).
TOR1AIP2	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
TOR1AIP2	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
TOR1AIP2	metacluster_15.4	SMAD6 (directAnnotation). SMAD6 (inferredBy_Orthology).
TOR1AIP2	transfac_pro__M05711	ZNF37A (directAnnotation).
TOR1AIP2	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
TOR1AIP2	taipale_tf_pairs__HOXB2_PAX1_NNMATTAGTCACGCWTSRNTG_CAP_repr	HOXB2; PAX1 (directAnnotation).
TOR1AIP2	taipale_tf_pairs__HOXB2_PAX9_NNMATTAGTCACGCWTSRNTG_CAP	HOXB2; PAX9 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."