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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TOB2

Summary for TOB2

Gene information	Gene symbol	TOB2
	Ensembl ID	ENSG00000183864
	Entrez ID	10766
	Gene name	transducer of ERBB2, 2
	Synonyms	APRO5\|bK223H9\|TOB4\|TOBL\|TROB2
	Gene type	protein_coding
	UniProtAcc	Q14106

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Dataset with differentially expressed gene: TOB2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.369905	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.336707	1.43e-27

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Expression of TOB2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TOB2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TOB2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TOB2	hsa-miR-10395-3p	97.1598	NM_016272
TOB2	hsa-miR-6783-3p	95.875	NM_016272
TOB2	hsa-miR-1343-3p	95.248	NM_016272
TOB2	hsa-miR-449a	95.1833	NM_016272
TOB2	hsa-miR-34a-5p	95.1833	NM_016272
TOB2	hsa-miR-34c-5p	94.3052	NM_016272
TOB2	hsa-miR-449b-5p	94.3052	NM_016272
TOB2	hsa-miR-3658	93.2792	NM_016272
TOB2	hsa-miR-7113-3p	93.083	NM_016272
TOB2	hsa-miR-6873-5p	92.4482	NM_016272
TOB2	hsa-miR-130a-5p	92.1676	NM_016272
TOB2	hsa-miR-661	92.0265	NM_016272
TOB2	hsa-miR-32-5p	91.7536	NM_016272
TOB2	hsa-miR-92b-3p	91.7536	NM_016272
TOB2	hsa-miR-92a-3p	91.7536	NM_016272
TOB2	hsa-miR-10526-3p	91.0904	NM_016272
TOB2	hsa-miR-6833-3p	90.9993	NM_016272
TOB2	hsa-miR-4744	90.5293	NM_016272
TOB2	hsa-miR-4671-3p	90.4547	NM_016272
TOB2	hsa-miR-4495	89.2774	NM_016272
TOB2	hsa-miR-363-3p	88.5974	NM_016272
TOB2	hsa-miR-25-3p	88.5974	NM_016272
TOB2	hsa-miR-367-3p	88.5974	NM_016272
TOB2	hsa-miR-6878-5p	88.565	NM_016272
TOB2	hsa-miR-4768-5p	88.5021	NM_016272
TOB2	hsa-miR-3175	88.3026	NM_016272
TOB2	hsa-miR-875-5p	86.5006	NM_016272
TOB2	hsa-miR-1253	86.2291	NM_016272
TOB2	hsa-miR-4753-3p	85.9261	NM_016272
TOB2	hsa-miR-1207-5p	85.4768	NM_016272
TOB2	hsa-miR-655-3p	85.2881	NM_016272
TOB2	hsa-miR-374c-5p	85.2881	NM_016272
TOB2	hsa-miR-6845-5p	84.8902	NM_016272
TOB2	hsa-miR-4763-3p	83.5139	NM_016272
TOB2	hsa-miR-6739-5p	83.0964	NM_016272
TOB2	hsa-miR-6733-5p	83.0964	NM_016272
TOB2	hsa-miR-4652-3p	83.0779	NM_016272
TOB2	hsa-miR-6809-3p	82.5862	NM_016272
TOB2	hsa-miR-4685-3p	82.1062	NM_016272
TOB2	hsa-miR-4287	82.1062	NM_016272
TOB2	hsa-miR-4427	81.6377	NM_016272
TOB2	hsa-miR-3140-5p	81.3314	NM_016272
TOB2	hsa-miR-548p	80.9599	NM_016272
TOB2	hsa-miR-12136	80.5392	NM_016272

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Motifs and transcription factors (TFs) regulating TOB2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TOB2	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
TOB2	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
TOB2	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
TOB2	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
TOB2	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
TOB2	transfac_pro__M06331	ZNF343 (directAnnotation).
TOB2	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).
TOB2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TOB2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TOB2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
TOB2	hdpi__ZNF304	ZNF304 (directAnnotation).
TOB2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
TOB2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
TOB2	transfac_pro__M01199	TRIM28 (directAnnotation).
TOB2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TOB2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TOB2	transfac_pro__M03806	ZBTB7C (directAnnotation).
TOB2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."