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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TNS3

Summary for TNS3

Gene information	Gene symbol	TNS3
	Ensembl ID	ENSG00000136205
	Entrez ID	64759
	Gene name	tensin 3
	Synonyms	FLJ13732\|H_NH0549I23.2\|TEM6\|TENS1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TNS3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.2786	1.98e-40
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.27109	1.34e-02
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.795521	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.294086	2.59e-12
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.396007	0.00e+00

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Expression of TNS3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TNS3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TNS3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TNS3	hsa-miR-3139	96.6769	NM_022748
TNS3	hsa-miR-708-5p	96.1636	NM_022748
TNS3	hsa-miR-28-5p	96.1636	NM_022748
TNS3	hsa-miR-12133	95.6416	NM_022748
TNS3	hsa-miR-96-5p	95.4401	NM_022748
TNS3	hsa-miR-1284	95.1846	NM_022748
TNS3	hsa-miR-1271-5p	94.6127	NM_022748
TNS3	hsa-miR-4714-5p	93.9395	NM_022748
TNS3	hsa-miR-4633-3p	93.8461	NM_022748
TNS3	hsa-miR-6500-5p	93.8461	NM_022748
TNS3	hsa-miR-1243	91.7605	NM_022748
TNS3	hsa-miR-4267	90.1207	NM_022748
TNS3	hsa-miR-624-3p	89.8036	NM_022748
TNS3	hsa-miR-182-5p	89.6989	NM_022748
TNS3	hsa-miR-5692a	89.0091	NM_022748
TNS3	hsa-miR-381-3p	87.5109	NM_022748
TNS3	hsa-miR-300	87.5109	NM_022748
TNS3	hsa-miR-2115-3p	86.9091	NM_022748
TNS3	hsa-miR-6757-3p	86.4589	NM_022748
TNS3	hsa-miR-8068	86.1391	NM_022748
TNS3	hsa-miR-5693	85.676	NM_022748
TNS3	hsa-miR-200a-3p	85.4206	NM_022748
TNS3	hsa-miR-141-3p	85.4206	NM_022748
TNS3	hsa-miR-4470	85.3477	NM_022748
TNS3	hsa-miR-4666a-3p	84.7219	NM_022748
TNS3	hsa-miR-5696	83.7126	NM_022748
TNS3	hsa-miR-4685-5p	82.8038	NM_022748
TNS3	hsa-miR-6837-5p	82.5678	NM_022748
TNS3	hsa-miR-98-3p	81.5101	NM_022748
TNS3	hsa-let-7a-3p	81.5101	NM_022748
TNS3	hsa-let-7f-1-3p	81.5101	NM_022748
TNS3	hsa-let-7b-3p	81.5101	NM_022748
TNS3	hsa-miR-4729	81.2472	NM_022748
TNS3	hsa-miR-206	80.9374	NM_022748
TNS3	hsa-miR-1-3p	80.9374	NM_022748
TNS3	hsa-miR-3145-3p	80.8008	NM_022748
TNS3	hsa-miR-516a-3p	80.5683	NM_022748
TNS3	hsa-miR-516b-3p	80.5683	NM_022748
TNS3	hsa-miR-7162-5p	80.5683	NM_022748
TNS3	hsa-miR-376c-3p	80.5387	NM_022748
TNS3	hsa-miR-590-3p	80.1468	NM_022748

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Motifs and transcription factors (TFs) regulating TNS3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TNS3	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
TNS3	cisbp__M08198	ELF1 (directAnnotation).
TNS3	transfac_pro__M04866	HDAC2 (directAnnotation).
TNS3	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
TNS3	swissregulon__hs__MTA3	MTA3 (directAnnotation).
TNS3	metacluster_74.19	HNF1A (inferredBy_Orthology).
TNS3	metacluster_141.4	GLIS2 (directAnnotation).
TNS3	cisbp__M02645	ETS1 (directAnnotation).
TNS3	jaspar__MA1933.1	SREBF2 (directAnnotation).
TNS3	transfac_pro__M05612	ZNF189 (directAnnotation).
TNS3	kznf__ZNF584_Imbeault2017_OM_RCADE	ZNF584 (directAnnotation).
TNS3	metacluster_21.5	HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology).
TNS3	metacluster_22.29	NFE2 (directAnnotation).
TNS3	tfdimers__MD00095	ELF1; NEUROD1 (directAnnotation).
TNS3	metacluster_31.7	FOXO1; FOXO3; FOXO6 (directAnnotation).
TNS3	transfac_pro__M06334	ZNF782 (directAnnotation).
TNS3	jaspar__MA1125.1	ZNF384 (directAnnotation).
TNS3	hocomoco__HSF1_HUMAN.H11MO.1.A	HSF1 (directAnnotation).
TNS3	metacluster_130.3	ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
TNS3	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
TNS3	taipale_tf_pairs__GCM1_CEBPB_ATRSGGGNNNNTTRCGYAAN_CAP_repr	CEBPB; GCM1 (directAnnotation).
TNS3	hdpi__TFAM	TFAM (directAnnotation).
TNS3	tfdimers__MD00051	GABPA; STAT6 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."