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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TNS1

Summary for TNS1

Gene information	Gene symbol	TNS1
	Ensembl ID	ENSG00000079308
	Entrez ID	7145
	Gene name	tensin 1
	Synonyms	DKFZp586K0617\|MXRA6\|PPP1R155\|TNS
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TNS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.279031	6.03e-08
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.440251	0.00e+00

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Expression of TNS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TNS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TNS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TNS1	hsa-miR-7110-3p	99.9977	NM_001308022
TNS1	hsa-miR-6873-3p	99.586	NM_001308022
TNS1	hsa-miR-6785-5p	97.5108	NM_001308022
TNS1	hsa-miR-4728-5p	97.5108	NM_001308022
TNS1	hsa-miR-6883-5p	97.2718	NM_001308022
TNS1	hsa-miR-149-3p	97.2718	NM_001308022
TNS1	hsa-miR-1233-5p	97.241	NM_001308022
TNS1	hsa-miR-6887-3p	96.6272	NM_001308022
TNS1	hsa-miR-6778-5p	96.2999	NM_001308022
TNS1	hsa-miR-6867-5p	95.0909	NM_001308022
TNS1	hsa-miR-642a-5p	94.0521	NM_001308022
TNS1	hsa-miR-200a-3p	94.0304	NM_001308022
TNS1	hsa-miR-141-3p	94.0304	NM_001308022
TNS1	hsa-miR-4520-2-3p	93.7952	NM_001308022
TNS1	hsa-miR-7850-5p	93.051	NM_001308022
TNS1	hsa-miR-31-5p	92.4054	NM_001308022
TNS1	hsa-miR-6817-3p	91.8826	NM_001308022
TNS1	hsa-miR-4443	91.7848	NM_001308022
TNS1	hsa-miR-765	91.5586	NM_001308022
TNS1	hsa-miR-11181-3p	91.343	NM_001308022
TNS1	hsa-miR-6892-3p	91.1714	NM_001308022
TNS1	hsa-miR-4784	90.4718	NM_001308022
TNS1	hsa-miR-3150b-3p	90.4718	NM_001308022
TNS1	hsa-miR-3622a-5p	89.8579	NM_001308022
TNS1	hsa-miR-182-5p	89.5928	NM_001308022
TNS1	hsa-miR-1224-5p	89.0267	NM_001308022
TNS1	hsa-miR-4725-3p	88.6723	NM_001308022
TNS1	hsa-miR-6780b-5p	88.6723	NM_001308022
TNS1	hsa-miR-4262	88.5178	NM_001308022
TNS1	hsa-miR-4520-3p	88.1545	NM_001308022
TNS1	hsa-miR-3679-3p	88.0622	NM_001308022
TNS1	hsa-miR-4731-5p	87.9914	NM_001308022
TNS1	hsa-miR-942-5p	86.9698	NM_001308022
TNS1	hsa-miR-6868-3p	85.8335	NM_001308022
TNS1	hsa-miR-320a-5p	85.6613	NM_001308022
TNS1	hsa-miR-5589-5p	85.5077	NM_001308022
TNS1	hsa-miR-181b-5p	85.4313	NM_001308022
TNS1	hsa-miR-181c-5p	85.4313	NM_001308022
TNS1	hsa-miR-181a-5p	85.4313	NM_001308022
TNS1	hsa-miR-181d-5p	85.4313	NM_001308022
TNS1	hsa-miR-3188	85.4254	NM_001308022
TNS1	hsa-miR-8071	85.0084	NM_001308022
TNS1	hsa-miR-340-5p	84.9837	NM_001308022
TNS1	hsa-miR-5579-3p	84.3089	NM_001308022
TNS1	hsa-miR-656-3p	83.9459	NM_001308022
TNS1	hsa-miR-1910-3p	83.8216	NM_001308022
TNS1	hsa-miR-6511a-5p	83.8216	NM_001308022
TNS1	hsa-miR-4729	83.5181	NM_001308022
TNS1	hsa-miR-3714	82.861	NM_001308022
TNS1	hsa-miR-548az-5p	82.8479	NM_001308022

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Motifs and transcription factors (TFs) regulating TNS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."