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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TNKS2

Summary for TNKS2

Gene information	Gene symbol	TNKS2
	Ensembl ID	ENSG00000107854
	Entrez ID	80351
	Gene name	tankyrase 2
	Synonyms	ARTD6\|PARP-5b\|PARP-5c\|PARP5B\|PARP5C\|pART6\|TANK2\|TNKL
	Gene type	protein_coding
	UniProtAcc	Q9H2K2

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Dataset with differentially expressed gene: TNKS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.258649	3.83e-18
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.265853	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.25194	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.252461	9.54e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.283381	0.00e+00

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Expression of TNKS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TNKS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TNKS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TNKS2	hsa-miR-3133	99.4877	NM_025235
TNKS2	hsa-miR-1-3p	98.7254	NM_025235
TNKS2	hsa-miR-206	98.7254	NM_025235
TNKS2	hsa-miR-582-5p	98.6919	NM_025235
TNKS2	hsa-miR-613	98.2844	NM_025235
TNKS2	hsa-miR-7159-5p	98.2491	NM_025235
TNKS2	hsa-miR-4760-3p	97.6748	NM_025235
TNKS2	hsa-miR-3163	97.4717	NM_025235
TNKS2	hsa-miR-4328	97.4636	NM_025235
TNKS2	hsa-miR-512-3p	97.0863	NM_025235
TNKS2	hsa-miR-4276	96.6603	NM_025235
TNKS2	hsa-miR-421	96.1345	NM_025235
TNKS2	hsa-miR-23b-3p	95.2701	NM_025235
TNKS2	hsa-miR-23c	95.2701	NM_025235
TNKS2	hsa-miR-23a-3p	95.2701	NM_025235
TNKS2	hsa-miR-3074-5p	94.8796	NM_025235
TNKS2	hsa-miR-424-3p	93.9988	NM_025235
TNKS2	hsa-miR-9-3p	93.7795	NM_025235
TNKS2	hsa-miR-6516-5p	92.792	NM_025235
TNKS2	hsa-miR-524-5p	92.6025	NM_025235
TNKS2	hsa-miR-520d-5p	92.6025	NM_025235
TNKS2	hsa-miR-548e-5p	92.2216	NM_025235
TNKS2	hsa-miR-4503	92.165	NM_025235
TNKS2	hsa-miR-4528	92.1389	NM_025235
TNKS2	hsa-miR-106b-5p	91.9203	NM_025235
TNKS2	hsa-miR-20a-5p	91.9203	NM_025235
TNKS2	hsa-miR-6771-3p	91.0996	NM_025235
TNKS2	hsa-miR-10395-3p	91.0161	NM_025235
TNKS2	hsa-miR-513b-5p	90.9199	NM_025235
TNKS2	hsa-miR-20b-5p	90.9194	NM_025235
TNKS2	hsa-miR-106a-5p	90.9194	NM_025235
TNKS2	hsa-miR-93-5p	90.9194	NM_025235
TNKS2	hsa-miR-519d-3p	90.9194	NM_025235
TNKS2	hsa-miR-17-5p	90.9194	NM_025235
TNKS2	hsa-miR-526b-3p	90.9194	NM_025235
TNKS2	hsa-miR-4477a	90.4638	NM_025235
TNKS2	hsa-miR-1252-3p	89.6178	NM_025235
TNKS2	hsa-miR-577	89.4939	NM_025235
TNKS2	hsa-miR-6128	89.3997	NM_025235
TNKS2	hsa-miR-548ba	89.3231	NM_025235
TNKS2	hsa-miR-570-5p	89.3231	NM_025235
TNKS2	hsa-miR-548ai	89.3231	NM_025235
TNKS2	hsa-miR-548ag	89.3231	NM_025235
TNKS2	hsa-miR-4282	89.2535	NM_025235
TNKS2	hsa-miR-4719	88.9841	NM_025235
TNKS2	hsa-miR-1912-3p	88.1767	NM_025235
TNKS2	hsa-miR-1295b-5p	88.0639	NM_025235
TNKS2	hsa-miR-224-5p	87.6482	NM_025235
TNKS2	hsa-miR-545-3p	86.7456	NM_025235
TNKS2	hsa-miR-4495	86.3771	NM_025235

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Motifs and transcription factors (TFs) regulating TNKS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TNKS2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
TNKS2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
TNKS2	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
TNKS2	jaspar__MA1721.1	ZNF93 (directAnnotation).
TNKS2	metacluster_151.2	ZNF23 (directAnnotation).
TNKS2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TNKS2	transfac_pro__M01253	CNOT3 (directAnnotation).
TNKS2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
TNKS2	jaspar__MA0748.2	YY2 (directAnnotation).
TNKS2	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
TNKS2	transfac_pro__M00938	E2F1 (directAnnotation).
TNKS2	metacluster_198.3	ZFP64 (directAnnotation).
TNKS2	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
TNKS2	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
TNKS2	cisbp__M00341	PAX6 (directAnnotation).
TNKS2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TNKS2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
TNKS2	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
TNKS2	metacluster_135.11	NR2C2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."