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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: TNIK

Summary for TNIK

Gene information	Gene symbol	TNIK
	Ensembl ID	ENSG00000154310
	Entrez ID	23043
	Gene name	TRAF2 and NCK interacting kinase
	Synonyms	KIAA0551
	Gene type	protein_coding
	UniProtAcc	Q9UKE5

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Dataset with differentially expressed gene: TNIK

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	3.1648	4.41e-10
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.397614	0.00e+00

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Expression of TNIK in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TNIK

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TNIK

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TNIK	hsa-miR-1276	98.9568	NM_001161560
TNIK	hsa-miR-30e-5p	97.4012	NM_001161560
TNIK	hsa-miR-30c-5p	97.4012	NM_001161560
TNIK	hsa-miR-30d-5p	97.4012	NM_001161560
TNIK	hsa-miR-30b-5p	97.4012	NM_001161560
TNIK	hsa-miR-30a-5p	97.4012	NM_001161560
TNIK	hsa-miR-4803	96.4829	NM_001161560
TNIK	hsa-miR-548c-3p	95.3537	NM_001161560
TNIK	hsa-miR-6508-3p	90.8132	NM_001161560
TNIK	hsa-miR-942-5p	90.6867	NM_001161564
TNIK	hsa-miR-8080	90.5664	NM_001161560
TNIK	hsa-miR-605-3p	90.3224	NM_001161560
TNIK	hsa-miR-3133	89.0267	NM_001161560
TNIK	hsa-miR-1244	88.0713	NM_001161560
TNIK	hsa-miR-3145-3p	87.5022	NM_001161564
TNIK	hsa-miR-10526-3p	87.4307	NM_001161560
TNIK	hsa-miR-6758-3p	87.0527	NM_001161560
TNIK	hsa-miR-548ba	87.0037	NM_001161560
TNIK	hsa-miR-5001-3p	86.9262	NM_001161560
TNIK	hsa-miR-1290	86.1253	NM_001161564
TNIK	hsa-miR-186-5p	85.7485	NM_001161560
TNIK	hsa-miR-9902	85.6105	NM_001161560
TNIK	hsa-miR-12123	85.453	NM_001161564
TNIK	hsa-miR-1324	85.287	NM_001161560
TNIK	hsa-miR-3678-3p	84.7789	NM_001161560
TNIK	hsa-miR-570-5p	84.2707	NM_001161560
TNIK	hsa-miR-548ai	84.2707	NM_001161560
TNIK	hsa-miR-548ag	84.2707	NM_001161560
TNIK	hsa-miR-6895-5p	82.602	NM_001161560
TNIK	hsa-miR-3936	82.2393	NM_001161564
TNIK	hsa-miR-6128	82.1734	NM_001161564
TNIK	hsa-miR-4262	81.7041	NM_001161564
TNIK	hsa-miR-6739-5p	81.5454	NM_001161560
TNIK	hsa-miR-3153	81.5454	NM_001161560
TNIK	hsa-miR-6733-5p	81.5454	NM_001161560
TNIK	hsa-miR-302a-5p	81.2491	NM_001161564
TNIK	hsa-miR-3074-5p	81.1874	NM_001161564
TNIK	hsa-miR-4719	80.4839	NM_001161560
TNIK	hsa-miR-4328	80.1294	NM_001161564
TNIK	hsa-miR-2052	80.0714	NM_001161560

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Motifs and transcription factors (TFs) regulating TNIK

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TNIK	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
TNIK	hdpi__ETV4	ETV4 (directAnnotation).
TNIK	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
TNIK	jaspar__MA0079.5	SP1 (directAnnotation).
TNIK	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
TNIK	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
TNIK	transfac_pro__M04617	ZBTB7A (directAnnotation).
TNIK	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
TNIK	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TNIK	transfac_pro__M07387	ZBTB7A (directAnnotation).
TNIK	transfac_pro__M07436	WT1 (directAnnotation).
TNIK	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
TNIK	transfac_pro__M00716	ZBTB14 (directAnnotation).
TNIK	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TNIK	hdpi__HIP2	UBE2K (directAnnotation).
TNIK	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TNIK	transfac_pro__M04893	TAF1 (directAnnotation).
TNIK	transfac_pro__M03876	ZBTB33 (directAnnotation).
TNIK	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TNIK	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TNIK	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
TNIK	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."