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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: TNFRSF11A

Summary for TNFRSF11A

Gene information	Gene symbol	TNFRSF11A
	Ensembl ID	ENSG00000141655
	Entrez ID	8792
	Gene name	TNF receptor superfamily member 11a
	Synonyms	CD265\|FEO\|LOH18CR1\|ODFR\|PDB2\|RANK\|TRANCE-R
	Gene type	protein_coding
	UniProtAcc	Q9Y6Q6

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Dataset with differentially expressed gene: TNFRSF11A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.445514	0.00e+00

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Expression of TNFRSF11A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TNFRSF11A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TNFRSF11A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TNFRSF11A	hsa-miR-651-3p	92.6156	NM_001270950
TNFRSF11A	hsa-miR-3148	91.8034	NM_001270950
TNFRSF11A	hsa-miR-4703-5p	86.3928	NM_001270950
TNFRSF11A	hsa-miR-4305	85.7547	NM_001270950
TNFRSF11A	hsa-miR-6795-5p	85.2253	NM_001270949
TNFRSF11A	hsa-miR-6887-5p	85.2253	NM_001270949
TNFRSF11A	hsa-miR-656-5p	84.8744	NM_001270950
TNFRSF11A	hsa-miR-6861-5p	84.7519	NM_001270950
TNFRSF11A	hsa-miR-1252-5p	83.2768	NM_001270950
TNFRSF11A	hsa-miR-4768-3p	83.2693	NM_001270950
TNFRSF11A	hsa-miR-656-3p	82.5811	NM_001270950
TNFRSF11A	hsa-miR-6792-3p	82.5062	NM_001270950
TNFRSF11A	hsa-miR-4691-5p	82.5062	NM_001270950
TNFRSF11A	hsa-miR-651-5p	82.0025	NM_001270950
TNFRSF11A	hsa-miR-4311	81.2274	NM_001270950
TNFRSF11A	hsa-miR-19a-3p	80.7153	NM_001270950
TNFRSF11A	hsa-miR-19b-3p	80.7153	NM_001270950
TNFRSF11A	hsa-miR-7113-5p	80.6495	NM_001270950

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Motifs and transcription factors (TFs) regulating TNFRSF11A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TNFRSF11A	metacluster_7.13	ZFX (directAnnotation).
TNFRSF11A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TNFRSF11A	cisbp__M00968	MTF2 (directAnnotation).
TNFRSF11A	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TNFRSF11A	metacluster_160.20	JUND; PRDM15 (directAnnotation).
TNFRSF11A	cisbp__M00341	PAX6 (directAnnotation).
TNFRSF11A	metacluster_198.3	ZFP64 (directAnnotation).
TNFRSF11A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TNFRSF11A	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TNFRSF11A	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
TNFRSF11A	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
TNFRSF11A	cisbp__M00788	ZFY (inferredBy_Orthology).
TNFRSF11A	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
TNFRSF11A	metacluster_175.1	ZNF283 (directAnnotation).
TNFRSF11A	hdpi__ZNF304	ZNF304 (directAnnotation).
TNFRSF11A	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
TNFRSF11A	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
TNFRSF11A	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TNFRSF11A	transfac_pro__M01199	TRIM28 (directAnnotation).
TNFRSF11A	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
TNFRSF11A	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TNFRSF11A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TNFRSF11A	transfac_pro__M03806	ZBTB7C (directAnnotation).
TNFRSF11A	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
TNFRSF11A	"ENMD-1198"	DB05959	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."