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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: TNFAIP3

Summary for TNFAIP3

Gene informationGene symbol

TNFAIP3

Ensembl ID

ENSG00000118503

Entrez ID

7128

Gene nameTNF alpha induced protein 3
SynonymsA20|OTUD7C
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: TNFAIP3

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE131984_Pac

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)ChemotherapypaclitaxelNAMalignant cells-0.7473420.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreMono/Macro0.4141220.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreNK cells0.3471530.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreCD4+ T cells0.5996420.00e+00

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostCD4+ T cells-0.4630181.70e-43

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreB cells0.3968465.29e-16

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreMono/Macro-0.4438761.47e-07

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreCD4+ T cells0.8479420.00e+00

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreCD8+ T cells0.6975320.00e+00

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelprePlasma cells0.6876790.00e+00

GSE153697

patientsBone marrow aspirateAcute lymphoblastic leukemiaRelapsed B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyanti-CD19 CAR-TNAMono/Macro-1.737484.37e-03

GSE169246_PacAteBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreMono/Macro0.858370.00e+00

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostCD4+ T cells0.3116331.67e-42

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostNK cells-0.588811.16e-03

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreCD4+ T cells0.9424960.00e+00

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreCD8+ T cells0.523530.00e+00

GSE197268_Axi-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyaxi-cel (CAR-T)postCD8+ T cells-0.3185430.00e+00

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNACD4+ T cells-0.44488.88e-05

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNACD8+ T cells-0.9562244.44e-13

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNAB cells-1.16242.85e-05

PMID34715028

patientsTumor tissueKidney cancerClear cell renal cell carcinoma (ccRCC)ImmunotherapynivolumabpostCD4+ T cells-1.634440.00e+00

PMID34715028

patientsTumor tissueKidney cancerClear cell renal cell carcinoma (ccRCC)ImmunotherapynivolumabpostCD8+ T cells-2.225650.00e+00

GSE164237

patientsPeripheral blood mononuclear cellsMelanomaAdvanced stages of melanoma ImmunotherapypembrolizumabpreCD8+ T cells-0.3442390.00e+00

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postMono/Macro0.664433.10e-03

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postNeutrophils0.9061222.71e-29

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postMast cells2.365483.46e-04

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postCD8+ T cells1.019180.00e+00

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postCD4+ T cells0.7257953.81e-30

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)postMono/Macro-0.3687920.00e+00

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preNK cells-0.3705847.81e-41

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preCD8+ T cells-0.4642380.00e+00

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postCD4+ T cells1.413720.00e+00

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postMono/Macro1.065354.69e-18

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postCD8+ T cells1.079270.00e+00

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postNeutrophils0.6949962.65e-09

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreMalignant cells0.3426590.00e+00

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreCD8+ T cells-0.49182.97e-27

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepreMono/Macro0.5840376.27e-39

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepreCD8+ T cells0.4890850.00e+00

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepreNK cells-0.3712628.95e-04

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasoneprecDCs0.30883.54e-02

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells-0.4758640.00e+00

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpostNK cells-0.2987069.50e-04

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpreMalignant cells-0.7055040.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostCD4+ T cells-0.7814710.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostNK cells-0.8366460.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostMalignant cells-0.894510.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreNK cells1.111062.48e-35

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreCD4+ T cells0.6835182.06e-18

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreCD8+ T cells0.7678625.12e-34

GSE152469

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibNACD8+ T cells0.5642779.84e-12

GSE131984_JQ1

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1NAMalignant cells-0.5858530.00e+00

GSE131984_JQ1Pac

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + paclitaxelNAMalignant cells-0.5042963.31e-26

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells-0.6910430.00e+00

GSE131984_Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapypalbociclibNAMalignant cells0.5789082.14e-29

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepostMono/Macro-0.2598024.75e-40

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells0.3590428.40e-40

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Expression of TNFAIP3 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to TNFAIP3

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.
Gene symbolMechanism

TNFAIP3

Unusual Activation of Pro-survival Pathway
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MicroRNAs (miRNA) regulating TNFAIP3

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
TNFAIP3hsa-miR-5692a99.8167NM_001270507
TNFAIP3hsa-miR-23a-3p97.24NM_001270507
TNFAIP3hsa-miR-23c97.24NM_001270507
TNFAIP3hsa-miR-23b-3p97.24NM_001270507
TNFAIP3hsa-miR-18a-5p94.9976NM_001270507
TNFAIP3hsa-miR-18b-5p94.9976NM_001270507
TNFAIP3hsa-miR-4735-3p94.9976NM_001270507
TNFAIP3hsa-miR-4446-5p94.6922NM_001270507
TNFAIP3hsa-miR-19b-3p94.3388NM_001270507
TNFAIP3hsa-miR-19a-3p94.3388NM_001270507
TNFAIP3hsa-miR-7845-5p93.6028NM_001270508
TNFAIP3hsa-miR-2116-5p91.8016NM_001270508
TNFAIP3hsa-miR-141-3p90.2061NM_001270507
TNFAIP3hsa-miR-200a-3p90.2061NM_001270507
TNFAIP3hsa-miR-656-3p88.2158NM_001270508
TNFAIP3hsa-miR-4743-3p88.1851NM_001270508
TNFAIP3hsa-miR-32-3p87.6895NM_001270507
TNFAIP3hsa-miR-29c-3p87.4084NM_001270507
TNFAIP3hsa-miR-29b-3p87.4084NM_001270507
TNFAIP3hsa-miR-29a-3p87.4084NM_001270507
TNFAIP3hsa-miR-4659b-3p86.9929NM_001270508
TNFAIP3hsa-miR-4659a-3p86.9929NM_001270508
TNFAIP3hsa-miR-397886.4196NM_001270508
TNFAIP3hsa-miR-6837-3p86.1886NM_001270507
TNFAIP3hsa-miR-4795-3p85.7763NM_001270507
TNFAIP3hsa-miR-431985.3415NM_001270507
TNFAIP3hsa-miR-3124-3p83.9046NM_001270508
TNFAIP3hsa-miR-125a-5p83.6832NM_001270507
TNFAIP3hsa-miR-125b-5p83.6832NM_001270507
TNFAIP3hsa-miR-463583.253NM_001270508
TNFAIP3hsa-miR-4653-5p83.0436NM_001270508
TNFAIP3hsa-miR-392183.0436NM_001270508
TNFAIP3hsa-miR-374a-5p82.9588NM_001270508
TNFAIP3hsa-miR-471982.7169NM_001270508
TNFAIP3hsa-miR-340-5p82.0877NM_001270508
TNFAIP3hsa-miR-374b-5p81.1846NM_001270508
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Motifs and transcription factors (TFs) regulating TNFAIP3

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
TNFAIP3hocomoco__SOX9_HUMAN.H11MO.1.BSOX9 (directAnnotation).
TNFAIP3transfac_pro__M01252E2F6 (directAnnotation).
TNFAIP3taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_reprCREB1 (directAnnotation).
TNFAIP3taipale__FOXD3_DBD_RTAAAYAFOXD3 (directAnnotation).
TNFAIP3transfac_pro__M04706RELA (directAnnotation).
TNFAIP3transfac_pro__M07431SOX11 (directAnnotation).
TNFAIP3jaspar__MA0442.2SOX10 (directAnnotation).
TNFAIP3hocomoco__FOXP1_HUMAN.H11MO.0.AFOXP1 (directAnnotation).
TNFAIP3metacluster_156.2ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
TNFAIP3metacluster_111.5E4F1; E4F1 (directAnnotation).
TNFAIP3transfac_pro__M01861ATF1 (directAnnotation).
TNFAIP3tfdimers__MD00192CHURC1 (directAnnotation).
TNFAIP3transfac_pro__M05916ZNF407 (directAnnotation).
TNFAIP3transfac_pro__M05977ZNF257 (directAnnotation).
TNFAIP3transfac_public__M00415ZEB1 (directAnnotation).
TNFAIP3swissregulon__hs__SOX10SOX10 (directAnnotation).
TNFAIP3homer__GGAAATTCCC_NFkB-p65-RelRELA (inferredBy_Orthology).
TNFAIP3metacluster_130.1ZNF713; ZNF713 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
TNFAIP3tfdimers__MD00259HOXA13; MAFA (directAnnotation).
TNFAIP3tfdimers__MD00044ELF1; ELF2; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV4; ETV6; ETV7; FLI1; GABPA; GABPB1; SIRT6; SPI1; SPIB (directAnnotation).
TNFAIP3taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAPATF4; TEF (directAnnotation).
TNFAIP3transfac_pro__M04860RXRA (directAnnotation).
TNFAIP3swissregulon__mm__Atf2ATF2 (inferredBy_Orthology).
TNFAIP3metacluster_32.45HDAC2 (directAnnotation).
TNFAIP3metacluster_190.7ILF2; NFATC1; NFATC1; NFATC1; NFATC1; NFATC2; NFATC2; NFATC2; NFATC3; NFATC3; NFATC3; NFATC3; NFATC4; NFATC4; NFATC4 (directAnnotation).
TNFAIP3hdpi__RANRAN (directAnnotation).
TNFAIP3swissregulon__hs__NFATC2NFATC2 (directAnnotation).
TNFAIP3transfac_pro__M01886NFATC3 (directAnnotation).
TNFAIP3transfac_pro__M07607NFATC3 (directAnnotation).
TNFAIP3hocomoco__PRDM6_HUMAN.H11MO.0.CPRDM6 (directAnnotation).
TNFAIP3cisbp__M05891SOX10 (directAnnotation).
TNFAIP3transfac_pro__M05380NR2E1 (inferredBy_Orthology).
TNFAIP3transfac_pro__M06104ZNF16 (directAnnotation).
TNFAIP3tfdimers__MD00012ETS1; YY1 (directAnnotation).
TNFAIP3hdpi__PRKRIRTHAP12 (directAnnotation).
TNFAIP3hdpi__ZNF671ZNF671 (directAnnotation).
TNFAIP3cisbp__M00377POU2F1 (directAnnotation).
TNFAIP3transfac_pro__M02027PARP1 (directAnnotation).
TNFAIP3tfdimers__MD00420E2F1; PAX4 (directAnnotation).
TNFAIP3transfac_pro__M03849SOX4 (directAnnotation).
TNFAIP3transfac_public__M00148SRY (directAnnotation).
TNFAIP3transfac_pro__M03854SRY (directAnnotation).
TNFAIP3transfac_pro__M07332POU3F2 (directAnnotation).
TNFAIP3transfac_pro__M05768ZNF544 (directAnnotation).
TNFAIP3transfac_pro__M05667ZNF35 (directAnnotation).
TNFAIP3taipale_tf_pairs__MYBL1_TBX21_AGGTGTGNCSGTTR_CAP_reprMYBL1; TBX21 (directAnnotation).
TNFAIP3metacluster_22.18BACH2 (inferredBy_Orthology).
TNFAIP3transfac_pro__M04814RELA (directAnnotation).
TNFAIP3metacluster_5.1HIVEP1; HIVEP1; NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; NFKB2; NFKB2; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELB; RELB (directAnnotation). NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; REL; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELB; RELB; RELB (inferredBy_Orthology).
TNFAIP3transfac_pro__M07066STAT6 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."