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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: TNF

Summary for TNF

Gene information	Gene symbol	TNF
	Ensembl ID	ENSG00000228978
	Entrez ID	7124
	Gene name	tumor necrosis factor
	Synonyms	DIF\|TNF-alpha\|TNFA\|TNFSF2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TNF

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	0.48996	4.41e-05
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.971549	1.25e-36
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	0.610911	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	0.647505	4.41e-28
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.676303	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.554383	9.24e-04
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	-0.278583	2.72e-04

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Expression of TNF in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TNF

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
TNF	B cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	B cells	CD4+ T cells	GSE169246_PacAteTissue	post	resistant
TNF	B cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	B cells	CD8+ T cells	GSE169246_PacAteTissue	post	resistant
TNF	B cells	CPI-SS04B4619D0	TNF_TNFRSF1A	TNF	TNFRSF1A	False	B cells	Mono/Macro	GSE169246_PacAteTissue	post	resistant
TNF	B cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	B cells	NK cells	GSE169246_PacAteTissue	post	resistant
TNF	B cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	B cells	pDCs	GSE169246_PacAteTissue	post	resistant
TNF	B cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	Mast cells	B cells	GSE169246_PacAteTissue	post	resistant
TNF	CD8+ T cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	B cells	CD8+ T cells	GSE169246_PacAteTissue	post	resistant
TNF	CD8+ T cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	CD4+ T cells	CD8+ T cells	GSE169246_PacAteTissue	post	resistant
TNF	CD8+ T cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	CD8+ T cells	CD4+ T cells	GSE169246_PacAteTissue	post	resistant
TNF	CD8+ T cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	CD8+ T cells	CD8+ T cells	GSE169246_PacAteTissue	post	resistant
TNF	CD8+ T cells	CPI-SS04B4619D0	TNF_TNFRSF1A	TNF	TNFRSF1A	False	CD8+ T cells	Mono/Macro	GSE169246_PacAteTissue	post	resistant
TNF	CD8+ T cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	CD8+ T cells	NK cells	GSE169246_PacAteTissue	post	resistant
TNF	CD8+ T cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	CD8+ T cells	pDCs	GSE169246_PacAteTissue	post	resistant
TNF	CD8+ T cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	Mast cells	CD8+ T cells	GSE169246_PacAteTissue	post	resistant
TNF	CD8+ T cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	Mono/Macro	CD8+ T cells	GSE169246_PacAteTissue	post	resistant
TNF	B cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	B cells	CD4+ T cells	GSE169246_PacAteTissue	post	sensitive
TNF	B cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	B cells	CD8+ T cells	GSE169246_PacAteTissue	post	sensitive
TNF	B cells	CPI-SS04B4619D0	TNF_TNFRSF1A	TNF	TNFRSF1A	False	B cells	Mono/Macro	GSE169246_PacAteTissue	post	sensitive
TNF	B cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	B cells	Mono/Macro	GSE169246_PacAteTissue	post	sensitive
TNF	B cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	B cells	NK cells	GSE169246_PacAteTissue	post	sensitive
TNF	B cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	B cells	pDCs	GSE169246_PacAteTissue	post	sensitive
TNF	CD8+ T cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	B cells	CD8+ T cells	GSE169246_PacAteTissue	post	sensitive
TNF	CD8+ T cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	Mono/Macro	CD8+ T cells	GSE169246_PacAteTissue	post	sensitive
TNF	CD8+ T cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	CD8+ T cells	CD4+ T cells	GSE169246_PacAteTissue	pre	resistant
TNF	CD8+ T cells	CPI-SS04B4619D0	TNF_TNFRSF1A	TNF	TNFRSF1A	False	CD8+ T cells	CD8+ T cells	GSE169246_PacAteTissue	pre	resistant
TNF	CD8+ T cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	CD8+ T cells	CD8+ T cells	GSE169246_PacAteTissue	pre	resistant
TNF	CD8+ T cells	CPI-SS04B4619D0	TNF_TNFRSF1A	TNF	TNFRSF1A	False	CD8+ T cells	Mono/Macro	GSE169246_PacAteTissue	pre	resistant
TNF	CD8+ T cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	CD8+ T cells	Mono/Macro	GSE169246_PacAteTissue	pre	resistant
TNF	CD8+ T cells	CPI-SS04B4619D0	TNF_TNFRSF1A	TNF	TNFRSF1A	False	CD8+ T cells	NK cells	GSE169246_PacAteTissue	pre	resistant
TNF	CD8+ T cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	CD8+ T cells	NK cells	GSE169246_PacAteTissue	pre	resistant
TNF	CD8+ T cells	CPI-SS04B4619D0	TNF_TNFRSF1A	TNF	TNFRSF1A	False	CD8+ T cells	cDCs	GSE169246_PacAteTissue	pre	resistant
TNF	CD8+ T cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	CD8+ T cells	pDCs	GSE169246_PacAteTissue	pre	resistant
TNF	CD8+ T cells	CPI-SS04B4619D0	TNF_TNFRSF1A	TNF	TNFRSF1A	False	Mono/Macro	CD8+ T cells	GSE169246_PacAteTissue	pre	resistant
TNF	CD8+ T cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	Mono/Macro	CD8+ T cells	GSE169246_PacAteTissue	pre	resistant
TNF	CD8+ T cells	CPI-SS04B4619D0	TNF_TNFRSF1A	TNF	TNFRSF1A	False	cDCs	CD8+ T cells	GSE169246_PacAteTissue	pre	resistant
TNF	CD8+ T cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	cDCs	CD8+ T cells	GSE169246_PacAteTissue	pre	resistant
TNF	CD8+ T cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	B cells	CD8+ T cells	GSE169246_PacAteTissue	pre	sensitive
TNF	CD8+ T cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	Mast cells	CD8+ T cells	GSE169246_PacAteTissue	pre	sensitive
TNF	CD8+ T cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	Mono/Macro	CD8+ T cells	GSE169246_PacAteTissue	pre	sensitive
TNF	B cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	B cells	CD4+ T cells	GSE169246_PacTissue	post	resistant
TNF	B cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	B cells	CD8+ T cells	GSE169246_PacTissue	post	resistant
TNF	B cells	CPI-SS04B4619D0	TNF_TNFRSF1A	TNF	TNFRSF1A	False	B cells	Mono/Macro	GSE169246_PacTissue	post	resistant
TNF	B cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	B cells	Mono/Macro	GSE169246_PacTissue	post	resistant
TNF	B cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	B cells	NK cells	GSE169246_PacTissue	post	resistant
TNF	B cells	CPI-SS04B4619D0	TNF_TNFRSF1A	TNF	TNFRSF1A	False	B cells	cDCs	GSE169246_PacTissue	post	resistant
TNF	B cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	B cells	cDCs	GSE169246_PacTissue	post	resistant
TNF	B cells	CPI-SS04B4619D0	TNF_TNFRSF1A	TNF	TNFRSF1A	False	B cells	pDCs	GSE169246_PacTissue	post	resistant
TNF	B cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	B cells	pDCs	GSE169246_PacTissue	post	resistant
TNF	B cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	Mono/Macro	B cells	GSE169246_PacTissue	post	resistant
TNF	B cells	CPI-SS0E7D5974D	TNF_TNFRSF1B	TNF	TNFRSF1B	False	Mono/Macro	B cells	GSE169246_PacTissue	post	sensitive

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TNF

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TNF	hsa-miR-5692a	99.9858	NM_000594
TNF	hsa-miR-34a-3p	96.0776	NM_000594
TNF	hsa-miR-4803	92.686	NM_000594
TNF	hsa-miR-4263	92.4353	NM_000594
TNF	hsa-miR-939-5p	88.6107	NM_000594
TNF	hsa-miR-150-5p	87.2833	NM_000594
TNF	hsa-miR-4262	86.9924	NM_000594
TNF	hsa-miR-3121-3p	86.3086	NM_000594
TNF	hsa-miR-181a-5p	86.255	NM_000594
TNF	hsa-miR-181d-5p	86.255	NM_000594
TNF	hsa-miR-181c-5p	86.255	NM_000594
TNF	hsa-miR-181b-5p	86.255	NM_000594
TNF	hsa-miR-4747-5p	85.977	NM_000594
TNF	hsa-miR-5196-5p	85.977	NM_000594
TNF	hsa-miR-10527-5p	84.784	NM_000594
TNF	hsa-miR-452-3p	83.6354	NM_000594
TNF	hsa-miR-4753-3p	83.5975	NM_000594
TNF	hsa-miR-3686	83.5454	NM_000594
TNF	hsa-miR-1343-5p	82.1904	NM_000594
TNF	hsa-miR-1236-5p	82.0682	NM_000594
TNF	hsa-miR-3617-3p	81.5207	NM_000594

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Motifs and transcription factors (TFs) regulating TNF

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TNF	jaspar__MA1933.1	SREBF2 (directAnnotation).
TNF	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
TNF	transfac_pro__M06532	ZNF461 (directAnnotation).
TNF	transfac_pro__M05707	ZNF239 (inferredBy_Orthology).
TNF	taipale_tf_pairs__PITX1_EOMES_RGGTGTKANNNNGGATTA_CAP_repr	EOMES; PITX1 (directAnnotation).
TNF	metacluster_168.4	ZNF652 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
TNF	"Adalimumab"	DB00051	biotech
TNF	"Afelimomab"	DB04956	biotech
TNF	"AME-527"	DB05879	biotech
TNF	"Amrinone"	DB01427	small molecule
TNF	"Andrographolide"	DB05767	small molecule
TNF	"Atiprimod"	DB05513	small molecule
TNF	"Binimetinib"	DB11967	small molecule
TNF	"Bryostatin 1"	DB11752	small molecule
TNF	"Certolizumab pegol"	DB08904	biotech
TNF	"Chloroquine"	DB00608	small molecule
TNF	"Clenbuterol"	DB01407	small molecule
TNF	"CRx-139"	DB05744	small molecule
TNF	"CYT007-TNFQb"	DB05758	biotech
TNF	"Dexanabinol"	DB06444	small molecule
TNF	"Dilmapimod"	DB12140	small molecule
TNF	"Epinephrine"	DB00668	small molecule
TNF	"Etanercept"	DB00005	biotech
TNF	"Ethyl pyruvate"	DB05869	small molecule
TNF	"Foreskin fibroblast (neonatal)"	DB10770	biotech
TNF	"Foreskin keratinocyte (neonatal)"	DB10772	biotech
TNF	"Glycyrrhizic acid"	DB13751	small molecule
TNF	"Golimumab"	DB06674	biotech
TNF	"Infliximab"	DB00065	biotech
TNF	"OMS-103HP"	DB05303	small molecule
TNF	"Onercept"	DB06495	biotech
TNF	"Plinabulin"	DB05992	small molecule
TNF	"PN0621"	DB05218	biotech
TNF	"Polaprezinc"	DB09221	small molecule
TNF	"Pomalidomide"	DB08910	small molecule
TNF	"PR-104"	DB05968	small molecule
TNF	"Pranlukast"	DB01411	small molecule
TNF	"Pseudoephedrine"	DB00852	small molecule
TNF	"SD118"	DB05207	small molecule
TNF	"Talmapimod"	DB05412	small molecule
TNF	"Trichostatin A"	DB04297	small molecule
TNF	"VX-702"	DB05470	small molecule
TNF	"YSIL6"	DB05017	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."