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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMX4

Summary for TMX4

Gene information	Gene symbol	TMX4
	Ensembl ID	ENSG00000125827
	Entrez ID	56255
	Gene name	thioredoxin related transmembrane protein 4
	Synonyms	DJ971N18.2\|KIAA1162\|PDIA14\|TXNDC13
	Gene type	protein_coding
	UniProtAcc	Q9H1E5

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Dataset with differentially expressed gene: TMX4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.433739	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.372329	7.12e-22
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.511933	0.00e+00

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Expression of TMX4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMX4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMX4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMX4	hsa-miR-7-2-3p	98.3981	NM_021156
TMX4	hsa-miR-7-1-3p	98.3981	NM_021156
TMX4	hsa-miR-3119	97.1812	NM_021156
TMX4	hsa-miR-5688	96.3492	NM_021156
TMX4	hsa-miR-190a-3p	96.3327	NM_021156
TMX4	hsa-miR-3148	96.2464	NM_021156
TMX4	hsa-miR-495-3p	94.6898	NM_021156
TMX4	hsa-miR-4795-3p	94.4856	NM_021156
TMX4	hsa-miR-200c-3p	94.4202	NM_021156
TMX4	hsa-miR-429	94.4202	NM_021156
TMX4	hsa-miR-200b-3p	94.4202	NM_021156
TMX4	hsa-miR-548c-3p	94.1226	NM_021156
TMX4	hsa-miR-579-3p	94.0052	NM_021156
TMX4	hsa-miR-664b-3p	94.0052	NM_021156
TMX4	hsa-miR-4666a-3p	93.6325	NM_021156
TMX4	hsa-miR-6839-5p	93.5012	NM_021156
TMX4	hsa-miR-3529-3p	93.3758	NM_021156
TMX4	hsa-miR-378j	92.4726	NM_021156
TMX4	hsa-miR-7856-5p	91.707	NM_021156
TMX4	hsa-miR-95-5p	90.8256	NM_021156
TMX4	hsa-miR-651-3p	90.7624	NM_021156
TMX4	hsa-miR-548m	90.6716	NM_021156
TMX4	hsa-miR-302c-5p	90.5886	NM_021156
TMX4	hsa-miR-3650	90.5134	NM_021156
TMX4	hsa-miR-5011-5p	90.4105	NM_021156
TMX4	hsa-miR-570-3p	89.9196	NM_021156
TMX4	hsa-miR-524-5p	89.3236	NM_021156
TMX4	hsa-miR-520d-5p	89.3236	NM_021156
TMX4	hsa-miR-3978	89.0537	NM_021156
TMX4	hsa-miR-551b-5p	88.9268	NM_021156
TMX4	hsa-miR-3662	88.6729	NM_021156
TMX4	hsa-miR-590-3p	88.4113	NM_021156
TMX4	hsa-miR-4251	88.2562	NM_021156
TMX4	hsa-miR-6758-3p	88.2279	NM_021156
TMX4	hsa-miR-4775	87.1789	NM_021156
TMX4	hsa-miR-196a-1-3p	87.1398	NM_021156
TMX4	hsa-miR-6835-3p	85.6381	NM_021156
TMX4	hsa-miR-4282	85.5735	NM_021156
TMX4	hsa-miR-6719-3p	84.8493	NM_021156
TMX4	hsa-miR-5696	84.3646	NM_021156
TMX4	hsa-miR-4786-5p	84.2155	NM_021156
TMX4	hsa-miR-520f-5p	83.7102	NM_021156
TMX4	hsa-miR-8063	83.5393	NM_021156
TMX4	hsa-miR-3977	83.1037	NM_021156
TMX4	hsa-miR-450a-2-3p	82.7719	NM_021156
TMX4	hsa-miR-6882-3p	82.3293	NM_021156
TMX4	hsa-miR-4261	82.3236	NM_021156
TMX4	hsa-miR-6771-3p	82.1393	NM_021156
TMX4	hsa-miR-4801	82.0718	NM_021156
TMX4	hsa-miR-338-5p	81.6737	NM_021156

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Motifs and transcription factors (TFs) regulating TMX4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMX4	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TMX4	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
TMX4	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TMX4	metacluster_7.13	ZFX (directAnnotation).
TMX4	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TMX4	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
TMX4	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TMX4	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TMX4	transfac_pro__M02090	E2F4 (directAnnotation).
TMX4	transfac_pro__M01714	KLF15 (directAnnotation).
TMX4	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
TMX4	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
TMX4	transfac_pro__M02089	E2F3 (directAnnotation).
TMX4	metacluster_3.14	WT1; WT1 (directAnnotation).
TMX4	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
TMX4	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
TMX4	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
TMX4	cisbp__M07938	E2F1 (directAnnotation).
TMX4	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
TMX4	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
TMX4	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TMX4	transfac_pro__M02898	SMAD3 (directAnnotation).
TMX4	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
TMX4	hdpi__HIP2	UBE2K (directAnnotation).
TMX4	hdpi__NRL	NRL (directAnnotation).
TMX4	transfac_pro__M00430	E2F1 (directAnnotation).
TMX4	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
TMX4	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
TMX4	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
TMX4	transfac_pro__M01837	KLF11 (directAnnotation).
TMX4	hdpi__TP73	TP73 (directAnnotation).
TMX4	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
TMX4	transfac_pro__M07310	SP5 (directAnnotation).
TMX4	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
TMX4	transfac_pro__M04817	ZBTB33 (directAnnotation).
TMX4	jaspar__MA0748.2	YY2 (directAnnotation).
TMX4	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
TMX4	transfac_pro__M00716	ZBTB14 (directAnnotation).
TMX4	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
TMX4	jaspar__MA1122.1	TFDP1 (directAnnotation).
TMX4	cisbp__M00968	MTF2 (directAnnotation).
TMX4	metacluster_163.2	ZNF682 (directAnnotation).
TMX4	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TMX4	transfac_pro__M04916	TAF1 (directAnnotation).
TMX4	transfac_pro__M00938	E2F1 (directAnnotation).
TMX4	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
TMX4	metacluster_90.3	ESRRA; ESRRA; ESRRB; NR5A1 (directAnnotation). ESRRA; NR5A1; NR5A1; NR5A2; NR5A2 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."