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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMEM59

Summary for TMEM59

Gene information	Gene symbol	TMEM59
	Ensembl ID	ENSG00000116209
	Entrez ID	9528
	Gene name	transmembrane protein 59
	Synonyms	C1orf8\|HSPC001
	Gene type	protein_coding
	UniProtAcc	Q9BXS4

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Dataset with differentially expressed gene: TMEM59

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.413608	2.59e-05
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.262401	1.12e-11
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.322299	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.272362	3.52e-07
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.442016	7.52e-21
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.67819	4.45e-29
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.45947	6.83e-34
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.462306	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.567886	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.297088	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	0.951774	8.52e-07
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	NK cells	0.366279	7.72e-22
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.260944	1.12e-11
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	0.585393	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	1.09344	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.429999	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.433534	0.00e+00

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Expression of TMEM59 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMEM59

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMEM59

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMEM59	hsa-miR-3662	99.7071	NM_001305043
TMEM59	hsa-miR-4282	96.7564	NM_001305052
TMEM59	hsa-miR-3646	94.6585	NM_001305043
TMEM59	hsa-miR-4668-5p	94.5978	NM_001305052
TMEM59	hsa-miR-520e-5p	92.6798	NM_001305052
TMEM59	hsa-miR-944	92.6364	NM_001305052
TMEM59	hsa-miR-590-3p	91.1973	NM_001305043
TMEM59	hsa-miR-498-5p	91.14	NM_001305052
TMEM59	hsa-miR-6796-3p	91.0905	NM_001305052
TMEM59	hsa-miR-3671	91.0083	NM_001305052
TMEM59	hsa-miR-335-5p	90.6615	NM_001305052
TMEM59	hsa-miR-580-5p	89.7703	NM_001305043
TMEM59	hsa-miR-142-3p	89.4051	NM_001305052
TMEM59	hsa-miR-4261	89.2312	NM_001305043
TMEM59	hsa-miR-570-3p	88.7022	NM_001305043
TMEM59	hsa-miR-510-3p	88.4386	NM_001305052
TMEM59	hsa-miR-548v	88.0274	NM_001305052
TMEM59	hsa-miR-889-3p	87.6158	NM_001305052
TMEM59	hsa-miR-607	87.6142	NM_001305052
TMEM59	hsa-miR-6504-3p	86.9501	NM_001305052
TMEM59	hsa-miR-7978	86.9334	NM_001305052
TMEM59	hsa-miR-548bb-3p	86.9228	NM_001305043
TMEM59	hsa-miR-548d-3p	86.9228	NM_001305043
TMEM59	hsa-miR-548ac	86.9228	NM_001305043
TMEM59	hsa-miR-548h-3p	86.9228	NM_001305043
TMEM59	hsa-miR-548z	86.9228	NM_001305043
TMEM59	hsa-miR-183-5p	85.7974	NM_001305052
TMEM59	hsa-miR-10399-5p	85.6691	NM_001305052
TMEM59	hsa-miR-561-3p	85.5799	NM_001305052
TMEM59	hsa-miR-657	85.3537	NM_001305052
TMEM59	hsa-miR-616-5p	84.8899	NM_001305052
TMEM59	hsa-miR-371b-5p	84.8899	NM_001305052
TMEM59	hsa-miR-373-5p	84.8899	NM_001305052
TMEM59	hsa-miR-3680-3p	83.4637	NM_001305052
TMEM59	hsa-miR-146a-3p	83.3661	NM_001305052
TMEM59	hsa-miR-4719	82.9321	NM_001305052
TMEM59	hsa-miR-147b-5p	82.402	NM_001305043
TMEM59	hsa-miR-92a-1-5p	82.0996	NM_001305052
TMEM59	hsa-miR-4280	81.9915	NM_001305052
TMEM59	hsa-miR-4735-5p	81.223	NM_001305052
TMEM59	hsa-miR-511-5p	80.7237	NM_001305052
TMEM59	hsa-miR-12123	80.3484	NM_001305043

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Motifs and transcription factors (TFs) regulating TMEM59

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMEM59	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
TMEM59	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TMEM59	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
TMEM59	transfac_pro__M05930	ZNF286A (directAnnotation).
TMEM59	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
TMEM59	transfac_pro__M04722	SPI1 (directAnnotation).
TMEM59	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
TMEM59	jaspar__MA1117.1	RELB (directAnnotation).
TMEM59	transfac_pro__M05804	ZBTB41 (inferredBy_Orthology).
TMEM59	transfac_pro__M06516	ZNF418 (directAnnotation).
TMEM59	taipale_cyt_meth__PITX2_YTAATCCN_FL	PITX2 (directAnnotation).
TMEM59	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
TMEM59	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
TMEM59	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
TMEM59	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
TMEM59	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
TMEM59	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
TMEM59	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
TMEM59	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
TMEM59	cisbp__M08198	ELF1 (directAnnotation).
TMEM59	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
TMEM59	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
TMEM59	taipale_tf_pairs__HOXB2_ELK1_TAATKRCCGGAAGNN_CAP_repr	ELK1; HOXB2 (directAnnotation).
TMEM59	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
TMEM59	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
TMEM59	taipale_tf_pairs__HOXD12_ELK3_NTTTAYNNCCGGAARNN_CAP_repr	ELK3; HOXD12 (directAnnotation).
TMEM59	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).
TMEM59	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
TMEM59	hdpi__EBF1	EBF1 (directAnnotation).
TMEM59	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
TMEM59	hdpi__TIMELESS	TIMELESS (directAnnotation).
TMEM59	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
TMEM59	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
TMEM59	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
TMEM59	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
TMEM59	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
TMEM59	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
TMEM59	transfac_pro__M05770	ZNF77 (directAnnotation).
TMEM59	transfac_pro__M04861	SIX5 (directAnnotation).
TMEM59	swissregulon__hs__HMX1	HMX1 (directAnnotation).
TMEM59	metacluster_143.19	PLAGL2; ZNF740 (directAnnotation).
TMEM59	transfac_pro__M00701	SMAD3 (directAnnotation).
TMEM59	metacluster_44.5	NKX3-1 (inferredBy_Orthology).
TMEM59	metacluster_44.4	NKX3-1 (inferredBy_Orthology).
TMEM59	transfac_pro__M04826	EP300 (directAnnotation).
TMEM59	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
TMEM59	metacluster_81.7	CREB1 (directAnnotation).
TMEM59	swissregulon__hs__ETV6	ETV6 (directAnnotation).
TMEM59	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
TMEM59	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."