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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMEM50B

Summary for TMEM50B

Gene information	Gene symbol	TMEM50B
	Ensembl ID	ENSG00000263160
	Entrez ID	757
	Gene name	transmembrane protein 50B
	Synonyms	C21orf4
	Gene type	protein_coding
	UniProtAcc	P56557

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Dataset with differentially expressed gene: TMEM50B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.75356	3.01e-04
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.540138	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.308979	2.50e-39

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Expression of TMEM50B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMEM50B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMEM50B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMEM50B	hsa-miR-4777-5p	94.8721	NM_006134
TMEM50B	hsa-miR-3664-3p	94.7652	NM_006134
TMEM50B	hsa-miR-4436b-5p	93.8527	NM_006134
TMEM50B	hsa-miR-24-3p	93.0442	NM_006134
TMEM50B	hsa-miR-182-5p	91.8382	NM_006134
TMEM50B	hsa-miR-3164	91.6667	NM_006134
TMEM50B	hsa-miR-6820-3p	91.6667	NM_006134
TMEM50B	hsa-miR-519a-3p	91.5014	NM_006134
TMEM50B	hsa-miR-519b-3p	91.5014	NM_006134
TMEM50B	hsa-miR-519c-3p	91.5014	NM_006134
TMEM50B	hsa-miR-1283	91.4553	NM_006134
TMEM50B	hsa-miR-4528	89.7082	NM_006134
TMEM50B	hsa-miR-4261	88.6267	NM_006134
TMEM50B	hsa-miR-6761-5p	88.0952	NM_006134
TMEM50B	hsa-miR-371a-5p	87.9932	NM_006134
TMEM50B	hsa-miR-147b-5p	86.2352	NM_006134
TMEM50B	hsa-miR-190a-3p	84.2367	NM_006134
TMEM50B	hsa-miR-454-3p	83.9025	NM_006134
TMEM50B	hsa-miR-5704	83.2716	NM_006134
TMEM50B	hsa-miR-4295	82.415	NM_006134
TMEM50B	hsa-miR-130b-3p	82.415	NM_006134
TMEM50B	hsa-miR-3666	82.415	NM_006134
TMEM50B	hsa-miR-301a-3p	82.415	NM_006134
TMEM50B	hsa-miR-301b-3p	82.415	NM_006134
TMEM50B	hsa-miR-130a-3p	82.415	NM_006134
TMEM50B	hsa-miR-3682-5p	81.8576	NM_006134
TMEM50B	hsa-miR-106a-3p	81.8409	NM_006134
TMEM50B	hsa-miR-7111-3p	80.2513	NM_006134

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Motifs and transcription factors (TFs) regulating TMEM50B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMEM50B	metacluster_7.13	ZFX (directAnnotation).
TMEM50B	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
TMEM50B	cisbp__M01863	ZNF711 (inferredBy_Orthology).
TMEM50B	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
TMEM50B	metacluster_151.2	ZNF23 (directAnnotation).
TMEM50B	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TMEM50B	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
TMEM50B	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TMEM50B	transfac_pro__M06071	ZNF814 (directAnnotation).
TMEM50B	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
TMEM50B	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TMEM50B	jaspar__MA0079.5	SP1 (directAnnotation).
TMEM50B	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
TMEM50B	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
TMEM50B	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
TMEM50B	metacluster_52.11	ZNF184 (directAnnotation).
TMEM50B	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
TMEM50B	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
TMEM50B	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
TMEM50B	transfac_pro__M04617	ZBTB7A (directAnnotation).
TMEM50B	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
TMEM50B	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TMEM50B	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
TMEM50B	transfac_pro__M07387	ZBTB7A (directAnnotation).
TMEM50B	transfac_pro__M07436	WT1 (directAnnotation).
TMEM50B	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
TMEM50B	transfac_pro__M00716	ZBTB14 (directAnnotation).
TMEM50B	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TMEM50B	hdpi__HIP2	UBE2K (directAnnotation).
TMEM50B	transfac_pro__M04893	TAF1 (directAnnotation).
TMEM50B	transfac_pro__M03876	ZBTB33 (directAnnotation).
TMEM50B	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TMEM50B	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TMEM50B	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
TMEM50B	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TMEM50B	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."