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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMEM43

Summary for TMEM43

Gene information	Gene symbol	TMEM43
	Ensembl ID	ENSG00000170876
	Entrez ID	79188
	Gene name	transmembrane protein 43
	Synonyms	ARVD5\|DKFZp586G1919\|LUMA\|MGC3222
	Gene type	protein_coding
	UniProtAcc	Q9BTV4

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Dataset with differentially expressed gene: TMEM43

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.424971	2.70e-34
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.289607	3.48e-02

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Expression of TMEM43 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMEM43

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMEM43

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMEM43	hsa-miR-12131	92.7142	NM_024334
TMEM43	hsa-miR-3680-3p	90.1974	NM_024334
TMEM43	hsa-miR-302f	88.8312	NM_024334
TMEM43	hsa-miR-4455	87.7781	NM_024334
TMEM43	hsa-miR-3619-5p	84.9083	NM_024334
TMEM43	hsa-miR-31-5p	84.5482	NM_024334
TMEM43	hsa-miR-4487	84.5141	NM_024334
TMEM43	hsa-miR-214-3p	83.8347	NM_024334
TMEM43	hsa-miR-761	83.8347	NM_024334
TMEM43	hsa-miR-6780b-5p	83.5389	NM_024334
TMEM43	hsa-miR-4725-3p	83.5389	NM_024334
TMEM43	hsa-miR-5690	82.8384	NM_024334
TMEM43	hsa-miR-122b-3p	81.0077	NM_024334
TMEM43	hsa-miR-21-3p	81.0077	NM_024334
TMEM43	hsa-miR-607	80.8336	NM_024334
TMEM43	hsa-miR-491-5p	80.6036	NM_024334
TMEM43	hsa-miR-6847-3p	80.0919	NM_024334

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Motifs and transcription factors (TFs) regulating TMEM43

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMEM43	metacluster_22.1	MAFF (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."