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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMEM39A

Summary for TMEM39A

Gene information	Gene symbol	TMEM39A
	Ensembl ID	ENSG00000176142
	Entrez ID	55254
	Gene name	transmembrane protein 39A
	Synonyms	FLJ10902\|SUSR2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TMEM39A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.28996	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.265966	1.62e-20

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Expression of TMEM39A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMEM39A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMEM39A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMEM39A	hsa-miR-3163	95.7268	NM_018266
TMEM39A	hsa-miR-6740-3p	95.489	NM_018266
TMEM39A	hsa-miR-4469	95.4667	NM_018266
TMEM39A	hsa-miR-200b-5p	95.447	NM_018266
TMEM39A	hsa-miR-200a-5p	95.447	NM_018266
TMEM39A	hsa-miR-4643	94.8918	NM_018266
TMEM39A	hsa-miR-548c-3p	93.8032	NM_018266
TMEM39A	hsa-miR-7158-3p	92.4493	NM_018266
TMEM39A	hsa-miR-3121-3p	90.4028	NM_018266
TMEM39A	hsa-miR-6800-3p	89.6996	NM_018266
TMEM39A	hsa-miR-495-3p	89.5484	NM_018266
TMEM39A	hsa-miR-5688	89.2886	NM_018266
TMEM39A	hsa-miR-6867-3p	88.9006	NM_018266
TMEM39A	hsa-miR-4637	87.5532	NM_018266
TMEM39A	hsa-miR-513b-5p	87.3765	NM_018266
TMEM39A	hsa-miR-466	86.2842	NM_018266
TMEM39A	hsa-miR-1207-3p	84.6473	NM_018266
TMEM39A	hsa-miR-1277-5p	84.1031	NM_018266
TMEM39A	hsa-miR-6079	83.9002	NM_018266
TMEM39A	hsa-miR-302a-5p	82.3342	NM_018266
TMEM39A	hsa-miR-4721	82.1726	NM_018266
TMEM39A	hsa-miR-4778-3p	81.0316	NM_018266
TMEM39A	hsa-miR-4666a-3p	80.0368	NM_018266

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Motifs and transcription factors (TFs) regulating TMEM39A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMEM39A	jaspar__MA1933.1	SREBF2 (directAnnotation).
TMEM39A	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."