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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMEM263

Summary for TMEM263

Gene information	Gene symbol	TMEM263
	Ensembl ID	ENSG00000151135
	Entrez ID	90488
	Gene name	transmembrane protein 263
	Synonyms	C12orf23\|MGC17943
	Gene type	protein_coding
	UniProtAcc	Q8WUH6

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Dataset with differentially expressed gene: TMEM263

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.4898	0.00e+00

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Expression of TMEM263 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMEM263

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMEM263

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMEM263	hsa-miR-4423-3p	97.9767	NM_001319661
TMEM263	hsa-miR-3143	95.5112	NM_001319661
TMEM263	hsa-miR-8087	94.7632	NM_001319666
TMEM263	hsa-miR-4760-5p	94.4564	NM_001319666
TMEM263	hsa-miR-4766-5p	93.7649	NM_001319661
TMEM263	hsa-miR-935	92.892	NM_001319661
TMEM263	hsa-miR-6512-5p	92.8302	NM_001319666
TMEM263	hsa-miR-7161-3p	92.6465	NM_001319666
TMEM263	hsa-miR-5088-3p	92.0905	NM_001319661
TMEM263	hsa-miR-23c	91.8718	NM_001319661
TMEM263	hsa-miR-23a-3p	91.8718	NM_001319661
TMEM263	hsa-miR-23b-3p	91.8718	NM_001319661
TMEM263	hsa-miR-1236-3p	91.8582	NM_001319661
TMEM263	hsa-miR-3180-5p	91.4555	NM_001319666
TMEM263	hsa-miR-8061	91.0546	NM_001319666
TMEM263	hsa-miR-5582-5p	90.2323	NM_001319661
TMEM263	hsa-miR-6719-3p	90.0546	NM_001319661
TMEM263	hsa-miR-1282	89.722	NM_001319666
TMEM263	hsa-miR-374c-5p	89.1957	NM_001319666
TMEM263	hsa-miR-655-3p	89.1957	NM_001319666
TMEM263	hsa-miR-211-5p	88.7234	NM_001319661
TMEM263	hsa-miR-204-5p	88.7234	NM_001319661
TMEM263	hsa-miR-6165	87.9378	NM_001319666
TMEM263	hsa-miR-3617-5p	87.1109	NM_001319666
TMEM263	hsa-miR-641	87.1109	NM_001319666
TMEM263	hsa-miR-4637	87.02	NM_001319661
TMEM263	hsa-miR-505-3p	86.8557	NM_001319666
TMEM263	hsa-miR-548ap-3p	86.7266	NM_001319666
TMEM263	hsa-miR-548aa	86.7266	NM_001319666
TMEM263	hsa-miR-548t-3p	86.7266	NM_001319666
TMEM263	hsa-miR-2681-5p	86.4157	NM_001319661
TMEM263	hsa-miR-3910	83.4454	NM_001319666
TMEM263	hsa-miR-4324	83.2621	NM_001319661
TMEM263	hsa-miR-4511	83.1594	NM_001319666
TMEM263	hsa-miR-4256	82.3618	NM_001319666
TMEM263	hsa-miR-11181-5p	82.3618	NM_001319666
TMEM263	hsa-miR-153-5p	82.355	NM_001319661
TMEM263	hsa-miR-3137	81.8916	NM_001319666
TMEM263	hsa-miR-4480	81.5845	NM_001319666
TMEM263	hsa-miR-670-3p	81.4755	NM_001319666
TMEM263	hsa-miR-425-5p	81.4422	NM_001319666
TMEM263	hsa-miR-543	81.1939	NM_001319661
TMEM263	hsa-miR-5186	81.0792	NM_001319661
TMEM263	hsa-miR-323b-3p	80.8636	NM_001319666
TMEM263	hsa-miR-6848-3p	80.8153	NM_001319666
TMEM263	hsa-miR-6843-3p	80.8153	NM_001319666
TMEM263	hsa-miR-452-3p	80.5289	NM_001319666
TMEM263	hsa-miR-3972	80.3393	NM_001319666
TMEM263	hsa-miR-1202	80.3393	NM_001319666

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Motifs and transcription factors (TFs) regulating TMEM263

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMEM263	metacluster_135.11	NR2C2 (directAnnotation).
TMEM263	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TMEM263	tfdimers__MD00038	TFAP2C (directAnnotation).
TMEM263	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TMEM263	metacluster_7.13	ZFX (directAnnotation).
TMEM263	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TMEM263	cisbp__M00968	MTF2 (directAnnotation).
TMEM263	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TMEM263	metacluster_160.20	JUND; PRDM15 (directAnnotation).
TMEM263	cisbp__M00341	PAX6 (directAnnotation).
TMEM263	metacluster_198.3	ZFP64 (directAnnotation).
TMEM263	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TMEM263	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TMEM263	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
TMEM263	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
TMEM263	cisbp__M00788	ZFY (inferredBy_Orthology).
TMEM263	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
TMEM263	metacluster_175.1	ZNF283 (directAnnotation).
TMEM263	hdpi__ZNF304	ZNF304 (directAnnotation).
TMEM263	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
TMEM263	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
TMEM263	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TMEM263	transfac_pro__M01199	TRIM28 (directAnnotation).
TMEM263	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
TMEM263	metacluster_151.2	ZNF23 (directAnnotation).
TMEM263	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TMEM263	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TMEM263	transfac_pro__M03806	ZBTB7C (directAnnotation).
TMEM263	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."