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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMEM237

Summary for TMEM237

Gene information	Gene symbol	TMEM237
	Ensembl ID	ENSG00000155755
	Entrez ID	65062
	Gene name	transmembrane protein 237
	Synonyms	ALS2CR4\|JBTS14
	Gene type	protein_coding
	UniProtAcc	Q96Q45

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Dataset with differentially expressed gene: TMEM237

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.305061	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.345387	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.316219	1.10e-20
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.375686	7.49e-18
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.279844	0.00e+00

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Expression of TMEM237 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMEM237

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMEM237

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMEM237	hsa-miR-589-5p	95.1422	NM_001044385
TMEM237	hsa-miR-335-3p	94.4065	NM_001044385
TMEM237	hsa-miR-3613-3p	93.9871	NM_001044385
TMEM237	hsa-miR-16-1-3p	92.1064	NM_001044385
TMEM237	hsa-miR-26b-3p	89.8396	NM_001044385
TMEM237	hsa-miR-7856-5p	89.7733	NM_001044385
TMEM237	hsa-miR-211-5p	89.6357	NM_001044385
TMEM237	hsa-miR-204-5p	89.6357	NM_001044385
TMEM237	hsa-miR-302c-5p	89.0278	NM_001044385
TMEM237	hsa-miR-548c-3p	88.9007	NM_001044385
TMEM237	hsa-miR-3143	88.0863	NM_001044385
TMEM237	hsa-miR-6817-3p	87.8194	NM_001044385
TMEM237	hsa-miR-670-5p	86.9211	NM_001044385
TMEM237	hsa-miR-493-5p	86.8117	NM_152388
TMEM237	hsa-miR-668-3p	86.546	NM_001044385
TMEM237	hsa-miR-4691-5p	86.4014	NM_001044385
TMEM237	hsa-miR-4528	85.9462	NM_001044385
TMEM237	hsa-miR-12124	85.615	NM_001044385
TMEM237	hsa-miR-154-5p	85.4292	NM_001044385
TMEM237	hsa-miR-6832-3p	84.9759	NM_001044385
TMEM237	hsa-miR-944	84.5243	NM_001044385
TMEM237	hsa-miR-33a-3p	83.8714	NM_001044385
TMEM237	hsa-miR-6867-5p	83.1244	NM_001044385
TMEM237	hsa-miR-4766-5p	82.3599	NM_001044385
TMEM237	hsa-miR-506-5p	80.8452	NM_001044385
TMEM237	hsa-miR-205-3p	80.4722	NM_001044385

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Motifs and transcription factors (TFs) regulating TMEM237

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMEM237	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
TMEM237	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
TMEM237	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
TMEM237	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
TMEM237	metacluster_81.7	CREB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."