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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMEM19

Summary for TMEM19

Gene information	Gene symbol	TMEM19
	Ensembl ID	ENSG00000139291
	Entrez ID	55266
	Gene name	transmembrane protein 19
	Synonyms	FLJ10936
	Gene type	protein_coding
	UniProtAcc	Q96HH6

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Dataset with differentially expressed gene: TMEM19

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.292944	1.86e-16
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.340017	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.284008	0.00e+00

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Expression of TMEM19 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMEM19

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMEM19

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMEM19	hsa-miR-3148	96.1722	NM_018279
TMEM19	hsa-miR-3916	93.7226	NM_018279
TMEM19	hsa-miR-3125	93.7226	NM_018279
TMEM19	hsa-miR-6859-5p	92.3091	NM_018279
TMEM19	hsa-miR-6885-3p	92.1854	NM_018279
TMEM19	hsa-miR-582-5p	91.7347	NM_018279
TMEM19	hsa-miR-494-3p	90.0728	NM_018279
TMEM19	hsa-miR-3613-3p	89.0608	NM_018279
TMEM19	hsa-miR-4294	87.3379	NM_018279
TMEM19	hsa-miR-197-3p	86.5466	NM_018279
TMEM19	hsa-miR-146b-5p	86.1046	NM_018279
TMEM19	hsa-miR-146a-5p	86.1046	NM_018279
TMEM19	hsa-miR-7153-5p	86.1046	NM_018279
TMEM19	hsa-miR-4795-3p	86.0883	NM_018279
TMEM19	hsa-miR-34b-5p	85.5904	NM_018279
TMEM19	hsa-miR-449c-5p	85.5904	NM_018279
TMEM19	hsa-miR-5688	82.8537	NM_018279
TMEM19	hsa-miR-495-3p	82.5631	NM_018279
TMEM19	hsa-miR-130b-5p	81.939	NM_018279
TMEM19	hsa-miR-520f-3p	81.1337	NM_018279
TMEM19	hsa-miR-2682-5p	80.7028	NM_018279
TMEM19	hsa-miR-4776-3p	80.3568	NM_018279

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Motifs and transcription factors (TFs) regulating TMEM19

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMEM19	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
TMEM19	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
TMEM19	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
TMEM19	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
TMEM19	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
TMEM19	transfac_pro__M04950	EGR1 (directAnnotation).
TMEM19	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
TMEM19	transfac_pro__M00652	NRF1 (directAnnotation).
TMEM19	hdpi__ETV4	ETV4 (directAnnotation).
TMEM19	transfac_pro__M04866	HDAC2 (directAnnotation).
TMEM19	jaspar__MA1122.1	TFDP1 (directAnnotation).
TMEM19	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
TMEM19	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_repr	ZNF385D (directAnnotation).
TMEM19	transfac_pro__M01298	MECP2 (directAnnotation).
TMEM19	hocomoco__GSC2_HUMAN.H11MO.0.D	GSC2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."