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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMEM184B

Summary for TMEM184B

Gene information	Gene symbol	TMEM184B
	Ensembl ID	ENSG00000198792
	Entrez ID	25829
	Gene name	transmembrane protein 184B
	Synonyms	C22orf5\|DKFZP586A1024\|FM08\|HS5O6A
	Gene type	protein_coding
	UniProtAcc	Q9Y519

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Dataset with differentially expressed gene: TMEM184B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.300881	2.98e-41

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Expression of TMEM184B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMEM184B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMEM184B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMEM184B	hsa-miR-539-3p	98.032	NM_001195071
TMEM184B	hsa-miR-7152-3p	97.9398	NM_001195071
TMEM184B	hsa-miR-485-3p	96.4843	NM_001195071
TMEM184B	hsa-miR-34a-5p	91.9341	NM_001195071
TMEM184B	hsa-miR-1297	90.7867	NM_001195071
TMEM184B	hsa-miR-26b-5p	90.7162	NM_001195071
TMEM184B	hsa-miR-26a-5p	90.7162	NM_001195071
TMEM184B	hsa-miR-4640-5p	89.6321	NM_001195071
TMEM184B	hsa-miR-4465	89.2712	NM_001195071
TMEM184B	hsa-miR-3663-5p	88.9368	NM_001195071
TMEM184B	hsa-miR-449a	88.8017	NM_001195071
TMEM184B	hsa-miR-4786-5p	88.7349	NM_001195071
TMEM184B	hsa-miR-12122	87.7476	NM_001195071
TMEM184B	hsa-miR-4726-5p	87.4277	NM_001195071
TMEM184B	hsa-miR-4456	87.312	NM_001195071
TMEM184B	hsa-miR-449b-5p	87.0141	NM_001195071
TMEM184B	hsa-miR-34c-5p	87.0141	NM_001195071
TMEM184B	hsa-miR-4728-5p	86.5144	NM_001195071
TMEM184B	hsa-miR-149-3p	86.5144	NM_001195071
TMEM184B	hsa-miR-6785-5p	86.5144	NM_001195071
TMEM184B	hsa-miR-6883-5p	86.5144	NM_001195071
TMEM184B	hsa-miR-1915-3p	85.43	NM_001195071
TMEM184B	hsa-miR-6735-3p	85.3717	NM_001195071
TMEM184B	hsa-miR-6764-5p	85.3018	NM_001195071
TMEM184B	hsa-miR-506-3p	84.6791	NM_001195071
TMEM184B	hsa-miR-124-3p	84.6791	NM_001195071
TMEM184B	hsa-miR-1249-5p	84.4783	NM_001195071
TMEM184B	hsa-miR-6797-5p	84.4783	NM_001195071
TMEM184B	hsa-miR-6780a-3p	84.3367	NM_001195071
TMEM184B	hsa-miR-4533	81.7883	NM_001195071
TMEM184B	hsa-miR-1178-3p	81.752	NM_001195071
TMEM184B	hsa-miR-4779	81.6583	NM_001195071
TMEM184B	hsa-miR-3184-5p	80.8454	NM_001195071
TMEM184B	hsa-miR-423-5p	80.8454	NM_001195071
TMEM184B	hsa-miR-6891-5p	80.8374	NM_001195071
TMEM184B	hsa-miR-4501	80.3453	NM_001195071
TMEM184B	hsa-miR-656-3p	80.0754	NM_001195071

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Motifs and transcription factors (TFs) regulating TMEM184B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMEM184B	metacluster_151.2	ZNF23 (directAnnotation).
TMEM184B	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."