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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMEM165

Summary for TMEM165

Gene information	Gene symbol	TMEM165
	Ensembl ID	ENSG00000134851
	Entrez ID	55858
	Gene name	transmembrane protein 165
	Synonyms	GDT1\|SLC64A1\|TMPT27\|TPARL
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TMEM165

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.271794	1.92e-06
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.313302	2.47e-26
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.540622	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.341907	2.24e-20
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.32973	1.63e-11
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.452785	9.93e-31
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.458425	0.00e+00

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Expression of TMEM165 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMEM165

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMEM165

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMEM165	hsa-miR-130a-5p	98.2449	NM_018475
TMEM165	hsa-miR-4753-3p	96.8646	NM_018475
TMEM165	hsa-let-7g-3p	95.0918	NM_018475
TMEM165	hsa-let-7a-2-3p	95.0918	NM_018475
TMEM165	hsa-miR-3658	94.0425	NM_018475
TMEM165	hsa-miR-4751	93.9235	NM_018475
TMEM165	hsa-miR-943	92.9267	NM_018475
TMEM165	hsa-miR-1255b-2-3p	92.5642	NM_018475
TMEM165	hsa-miR-4262	92.4166	NM_018475
TMEM165	hsa-miR-181b-5p	90.8162	NM_018475
TMEM165	hsa-miR-181d-5p	90.8162	NM_018475
TMEM165	hsa-miR-181a-5p	90.8162	NM_018475
TMEM165	hsa-miR-181c-5p	90.8162	NM_018475
TMEM165	hsa-miR-3130-3p	89.1303	NM_018475
TMEM165	hsa-miR-4781-3p	88.8321	NM_018475
TMEM165	hsa-miR-4803	88.64	NM_018475
TMEM165	hsa-miR-3671	86.782	NM_018475
TMEM165	hsa-miR-892b	86.6712	NM_018475
TMEM165	hsa-miR-4644	86.416	NM_018475
TMEM165	hsa-miR-4306	86.416	NM_018475
TMEM165	hsa-miR-185-5p	86.416	NM_018475
TMEM165	hsa-miR-6884-3p	86.3052	NM_018475
TMEM165	hsa-miR-187-5p	83.8152	NM_018475
TMEM165	hsa-miR-583	80.7066	NM_018475

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Motifs and transcription factors (TFs) regulating TMEM165

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMEM165	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
TMEM165	metacluster_151.2	ZNF23 (directAnnotation).
TMEM165	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TMEM165	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TMEM165	transfac_pro__M05628	ZNF735 (directAnnotation).
TMEM165	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TMEM165	jaspar__MA1933.1	SREBF2 (directAnnotation).
TMEM165	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
TMEM165	transfac_pro__M01299	MECP2 (directAnnotation).
TMEM165	transfac_pro__M05538	ZNF536 (inferredBy_Orthology).
TMEM165	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
TMEM165	tfdimers__MD00031	MYB; ZEB1 (directAnnotation).
TMEM165	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
TMEM165	metacluster_173.2	ATF3; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; BATF3; CREB3; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L4; XBP1; XBP1; XBP1; XBP1 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM (inferredBy_Orthology).
TMEM165	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
TMEM165	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
TMEM165	transfac_pro__M05768	ZNF544 (directAnnotation).
TMEM165	taipale_tf_pairs__CEBPG_CREB3L1_NGCCACGCAAYN_CAP_repr	CEBPG; CREB3L1 (directAnnotation).
TMEM165	jaspar__MA1125.1	ZNF384 (directAnnotation).
TMEM165	taipale_tf_pairs__GCM1_CEBPB_ATRSGGGNNNNTTRCGYAAN_CAP_repr	CEBPB; GCM1 (directAnnotation).
TMEM165	transfac_pro__M01298	MECP2 (directAnnotation).
TMEM165	hdpi__TP73	TP73 (directAnnotation).
TMEM165	swissregulon__hs__ETV6	ETV6 (directAnnotation).
TMEM165	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
TMEM165	hdpi__ELF2	ELF2 (directAnnotation).
TMEM165	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
TMEM165	metacluster_81.7	CREB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."