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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMEM144

Summary for TMEM144

Gene information	Gene symbol	TMEM144
	Ensembl ID	ENSG00000164124
	Entrez ID	55314
	Gene name	transmembrane protein 144
	Synonyms	FLJ11155
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TMEM144

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.744555	0.00e+00

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Expression of TMEM144 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMEM144

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMEM144

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMEM144	hsa-miR-3662	96.9938	NM_018342
TMEM144	hsa-miR-4262	95.023	NM_018342
TMEM144	hsa-miR-205-3p	93.9947	NM_018342
TMEM144	hsa-miR-153-5p	92.5749	NM_018342
TMEM144	hsa-miR-302c-5p	91.6242	NM_018342
TMEM144	hsa-miR-610	91.3167	NM_018342
TMEM144	hsa-miR-181d-5p	91.132	NM_018342
TMEM144	hsa-miR-181c-5p	91.132	NM_018342
TMEM144	hsa-miR-181b-5p	91.132	NM_018342
TMEM144	hsa-miR-181a-5p	91.132	NM_018342
TMEM144	hsa-miR-4789-3p	89.5219	NM_018342
TMEM144	hsa-miR-4719	89.111	NM_018342
TMEM144	hsa-miR-4282	88.8672	NM_018342
TMEM144	hsa-miR-9986	87.0997	NM_018342
TMEM144	hsa-miR-4318	86.6466	NM_018342
TMEM144	hsa-miR-4766-3p	85.5765	NM_018342
TMEM144	hsa-miR-4653-5p	85.3925	NM_018342
TMEM144	hsa-miR-3921	85.3925	NM_018342
TMEM144	hsa-miR-2110	85.3153	NM_018342
TMEM144	hsa-miR-4273	83.3337	NM_018342
TMEM144	hsa-miR-3132	83.0911	NM_018342
TMEM144	hsa-miR-3617-3p	82.7853	NM_018342
TMEM144	hsa-miR-1294	81.8858	NM_018342
TMEM144	hsa-miR-1976	81.8407	NM_018342
TMEM144	hsa-miR-450a-2-3p	81.82	NM_018342
TMEM144	hsa-miR-223-5p	81.1896	NM_018342
TMEM144	hsa-miR-6844	81.0584	NM_018342
TMEM144	hsa-miR-556-5p	81.0579	NM_018342
TMEM144	hsa-miR-7703	80.6806	NM_018342
TMEM144	hsa-miR-7156-5p	80.5885	NM_018342
TMEM144	hsa-miR-500b-3p	80.3357	NM_018342

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Motifs and transcription factors (TFs) regulating TMEM144

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMEM144	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TMEM144	cisbp__M00808	MYPOP (inferredBy_Orthology).
TMEM144	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."