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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMEM135

Summary for TMEM135

Gene information	Gene symbol	TMEM135
	Ensembl ID	ENSG00000166575
	Entrez ID	65084
	Gene name	transmembrane protein 135
	Synonyms	FLJ22104
	Gene type	protein_coding
	UniProtAcc	Q86UB9

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Dataset with differentially expressed gene: TMEM135

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.838359	7.27e-04

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Expression of TMEM135 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMEM135

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMEM135

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMEM135	hsa-miR-345-3p	99.8911	NM_001168724
TMEM135	hsa-miR-670-5p	99.5065	NM_001168724
TMEM135	hsa-miR-4319	99.0334	NM_001168724
TMEM135	hsa-miR-4799-5p	97.9105	NM_001168724
TMEM135	hsa-miR-559	97.6765	NM_022918
TMEM135	hsa-miR-885-5p	97.2782	NM_022918
TMEM135	hsa-miR-4732-3p	97.1535	NM_001168724
TMEM135	hsa-miR-548y	96.9886	NM_022918
TMEM135	hsa-miR-548am-5p	96.9886	NM_022918
TMEM135	hsa-miR-548c-5p	96.9886	NM_022918
TMEM135	hsa-miR-548ar-5p	96.9886	NM_022918
TMEM135	hsa-miR-548ab	96.9886	NM_022918
TMEM135	hsa-miR-548i	96.9886	NM_022918
TMEM135	hsa-miR-548ak	96.9886	NM_022918
TMEM135	hsa-miR-548a-5p	96.9886	NM_022918
TMEM135	hsa-miR-548d-5p	96.9886	NM_022918
TMEM135	hsa-miR-548ae-5p	96.9886	NM_022918
TMEM135	hsa-miR-548ad-5p	96.9886	NM_022918
TMEM135	hsa-miR-548j-5p	96.9886	NM_022918
TMEM135	hsa-miR-548b-5p	96.9886	NM_022918
TMEM135	hsa-miR-548h-5p	96.9886	NM_022918
TMEM135	hsa-miR-548w	96.9886	NM_022918
TMEM135	hsa-miR-548ay-5p	96.9886	NM_022918
TMEM135	hsa-miR-548as-5p	96.9886	NM_022918
TMEM135	hsa-miR-548o-5p	96.9886	NM_022918
TMEM135	hsa-miR-548au-5p	96.9886	NM_022918
TMEM135	hsa-miR-548bb-5p	96.9886	NM_022918
TMEM135	hsa-miR-548ap-5p	96.9886	NM_022918
TMEM135	hsa-miR-125a-5p	96.9345	NM_001168724
TMEM135	hsa-miR-125b-5p	96.9345	NM_001168724
TMEM135	hsa-miR-6792-5p	96.9105	NM_022918
TMEM135	hsa-miR-548aq-5p	96.7542	NM_022918
TMEM135	hsa-miR-4477a	96.6706	NM_001168724
TMEM135	hsa-miR-3662	96.6375	NM_001168724
TMEM135	hsa-miR-513b-3p	96.2149	NM_022918
TMEM135	hsa-miR-6844	95.8622	NM_022918
TMEM135	hsa-miR-494-3p	95.6129	NM_022918
TMEM135	hsa-miR-3163	94.8097	NM_022918
TMEM135	hsa-miR-6515-3p	94.5598	NM_001168724
TMEM135	hsa-miR-4775	93.8442	NM_001168724
TMEM135	hsa-miR-6513-3p	93.7795	NM_001168724
TMEM135	hsa-miR-23a-3p	92.4469	NM_001168724
TMEM135	hsa-miR-23c	92.4469	NM_001168724
TMEM135	hsa-miR-23b-3p	92.4469	NM_001168724
TMEM135	hsa-miR-200a-3p	91.8314	NM_001168724
TMEM135	hsa-miR-141-3p	91.8314	NM_001168724
TMEM135	hsa-miR-4282	91.1617	NM_022918
TMEM135	hsa-miR-376c-3p	90.6646	NM_022918
TMEM135	hsa-miR-5011-5p	90.5852	NM_022918
TMEM135	hsa-miR-3646	90.579	NM_022918

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Motifs and transcription factors (TFs) regulating TMEM135

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMEM135	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
TMEM135	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
TMEM135	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
TMEM135	transfac_pro__M04617	ZBTB7A (directAnnotation).
TMEM135	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
TMEM135	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TMEM135	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
TMEM135	transfac_pro__M07387	ZBTB7A (directAnnotation).
TMEM135	transfac_pro__M07436	WT1 (directAnnotation).
TMEM135	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
TMEM135	transfac_pro__M00716	ZBTB14 (directAnnotation).
TMEM135	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TMEM135	hdpi__HIP2	UBE2K (directAnnotation).
TMEM135	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TMEM135	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
TMEM135	transfac_pro__M04893	TAF1 (directAnnotation).
TMEM135	transfac_pro__M03876	ZBTB33 (directAnnotation).
TMEM135	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TMEM135	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TMEM135	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
TMEM135	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TMEM135	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."