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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMEM132C

Summary for TMEM132C

Gene information	Gene symbol	TMEM132C
	Ensembl ID	ENSG00000181234
	Entrez ID	92293
	Gene name	transmembrane protein 132C
	Synonyms	DKFZp761O2018\|PPP1R152
	Gene type	protein_coding
	UniProtAcc	Q8N3T6

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Dataset with differentially expressed gene: TMEM132C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.461968	0.00e+00

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Expression of TMEM132C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMEM132C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMEM132C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMEM132C	hsa-miR-6124	96.0107	NM_001136103
TMEM132C	hsa-miR-187-5p	95.1818	NM_001136103
TMEM132C	hsa-miR-3134	92.2531	NM_001136103
TMEM132C	hsa-miR-623	91.564	NM_001136103
TMEM132C	hsa-miR-4642	89.4377	NM_001136103
TMEM132C	hsa-miR-4753-3p	88.9687	NM_001136103
TMEM132C	hsa-miR-2116-3p	87.8906	NM_001136103
TMEM132C	hsa-miR-629-3p	86.5225	NM_001136103
TMEM132C	hsa-miR-6772-3p	86.3952	NM_001136103
TMEM132C	hsa-miR-1913	85.9042	NM_001136103
TMEM132C	hsa-miR-130a-5p	85.7361	NM_001136103
TMEM132C	hsa-miR-12117	84.989	NM_001136103
TMEM132C	hsa-miR-7-2-3p	83.8397	NM_001136103
TMEM132C	hsa-miR-7-1-3p	83.8397	NM_001136103
TMEM132C	hsa-miR-1297	83.1056	NM_001136103
TMEM132C	hsa-miR-1283	82.7198	NM_001136103
TMEM132C	hsa-miR-770-5p	80.8494	NM_001136103
TMEM132C	hsa-miR-4712-5p	80.8494	NM_001136103
TMEM132C	hsa-miR-6780b-3p	80.2685	NM_001136103

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Motifs and transcription factors (TFs) regulating TMEM132C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMEM132C	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
TMEM132C	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
TMEM132C	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
TMEM132C	metacluster_3.14	WT1; WT1 (directAnnotation).
TMEM132C	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
TMEM132C	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."