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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMEM127

Summary for TMEM127

Gene information	Gene symbol	TMEM127
	Ensembl ID	ENSG00000135956
	Entrez ID	55654
	Gene name	transmembrane protein 127
	Synonyms	FLJ20507\|FLJ22257
	Gene type	protein_coding
	UniProtAcc	O75204

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Dataset with differentially expressed gene: TMEM127

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.427033	0.00e+00

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Expression of TMEM127 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMEM127

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMEM127

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMEM127	hsa-miR-20a-5p	94.2278	NM_001193304
TMEM127	hsa-miR-106b-5p	94.2278	NM_001193304
TMEM127	hsa-miR-23b-5p	93.6991	NM_017849
TMEM127	hsa-miR-3190-5p	93.4055	NM_017849
TMEM127	hsa-miR-519d-3p	93.1913	NM_001193304
TMEM127	hsa-miR-17-5p	93.1913	NM_001193304
TMEM127	hsa-miR-93-5p	93.1913	NM_001193304
TMEM127	hsa-miR-106a-5p	93.1913	NM_001193304
TMEM127	hsa-miR-20b-5p	93.1913	NM_001193304
TMEM127	hsa-miR-3179	93.1727	NM_001193304
TMEM127	hsa-miR-3187-5p	93.0729	NM_017849
TMEM127	hsa-miR-6852-5p	92.5972	NM_017849
TMEM127	hsa-miR-1285-3p	92.4835	NM_017849
TMEM127	hsa-miR-5189-5p	92.4835	NM_017849
TMEM127	hsa-miR-526b-3p	92.3202	NM_001193304
TMEM127	hsa-miR-4668-5p	91.1889	NM_017849
TMEM127	hsa-miR-548t-5p	90.4761	NM_001193304
TMEM127	hsa-miR-548az-5p	90.4761	NM_001193304
TMEM127	hsa-miR-23a-5p	90.4162	NM_017849
TMEM127	hsa-miR-4731-5p	89.8692	NM_017849
TMEM127	hsa-miR-612	89.7878	NM_017849
TMEM127	hsa-miR-6860	89.7878	NM_017849
TMEM127	hsa-miR-12136	89.0562	NM_001193304
TMEM127	hsa-miR-6077	89.0303	NM_001193304
TMEM127	hsa-miR-29b-2-5p	88.7482	NM_017849
TMEM127	hsa-miR-4492	88.6602	NM_017849
TMEM127	hsa-miR-6508-5p	88.5602	NM_017849
TMEM127	hsa-miR-6873-5p	88.3901	NM_017849
TMEM127	hsa-miR-8067	88.2671	NM_017849
TMEM127	hsa-miR-1252-5p	86.797	NM_001193304
TMEM127	hsa-miR-4690-3p	86.2425	NM_017849
TMEM127	hsa-miR-5685	86.2425	NM_017849
TMEM127	hsa-miR-4796-3p	86.2195	NM_001193304
TMEM127	hsa-miR-4755-5p	85.7174	NM_017849
TMEM127	hsa-miR-5006-3p	85.7174	NM_017849
TMEM127	hsa-miR-5584-5p	85.4573	NM_017849
TMEM127	hsa-miR-6829-5p	84.5182	NM_017849
TMEM127	hsa-miR-3678-3p	84.2991	NM_017849
TMEM127	hsa-miR-2467-3p	84.2047	NM_017849
TMEM127	hsa-miR-663b	84.0126	NM_017849
TMEM127	hsa-miR-4516	83.9731	NM_017849
TMEM127	hsa-miR-6776-5p	83.6058	NM_017849
TMEM127	hsa-miR-6856-3p	81.4024	NM_017849
TMEM127	hsa-miR-6739-5p	81.1899	NM_017849
TMEM127	hsa-miR-4700-5p	81.1009	NM_017849
TMEM127	hsa-miR-4725-3p	81.0995	NM_017849
TMEM127	hsa-miR-6780b-5p	81.0995	NM_017849
TMEM127	hsa-miR-4667-5p	80.2659	NM_017849

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Motifs and transcription factors (TFs) regulating TMEM127

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."