Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE186960 | Panc1 cell line | Cell line | Pancreatic cancer | Pancreatic ductal adenocarcinoma (PDAC) | Chemotherapy | gemcitabine | NA | Malignant cells | -0.33453 | 1.28e-22 |
GSE163836 | FCIBC02 cell line | Cell line | Breast cancer | Inflammatory breast cancer | Chemotherapy | paclitaxel | NA | Malignant cells | -0.850353 | 0.00e+00 |
GSE169246_PacTissue | patients | Tumor tissue | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | post | Plasma cells | 0.292476 | 1.50e-07 |
GSE153697 | patients | Bone marrow aspirate | Acute lymphoblastic leukemia | Relapsed B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | anti-CD19 CAR-T | NA | Malignant cells | 0.355734 | 3.26e-19 |
GSE169246_PacAteTissue | patients | Tumor tissue | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Immunotherapy | atezolizumab + paclitaxel | post | Plasma cells | -0.292046 | 4.83e-03 |
GSE207422_Sin | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | Mono/Macro | 0.299512 | 7.43e-04 |
GSE207422_Tor | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | Malignant cells | 0.442372 | 2.05e-23 |
GSE161801_PI | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Targeted therapy | carfilzomib + dexamethasone | pre | Malignant cells | -0.875444 | 0.00e+00 |
GSE139386 | H3122 cell line | Cell line | Lung cancer | EML4-ALK fusion-positive non-small cell lung cancer (NSCLC) | Targeted therapy | ceritinib | NA | Malignant cells | 0.5784 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | Malignant cells | 0.475297 | 0.00e+00 |
GSE131984_JQ1 | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 | NA | Malignant cells | -0.561638 | 0.00e+00 |
GSE131984_JQ1Pac | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 + paclitaxel | NA | Malignant cells | -0.477886 | 1.31e-26 |
GSE131984_JQ1Pal | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 + palbociclib | NA | Malignant cells | -0.817653 | 0.00e+00 |
GSE131984_Pal | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | palbociclib | NA | Malignant cells | -0.460209 | 4.96e-27 |
GSE161801_IMiD | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Targeted therapy | pomalidomide + dexamethasone OR lenalidomide + dexamethasone | post | Malignant cells | -0.71667 | 0.00e+00 |
GSE175716 | PDX | Tumor tissue | Liver cancer | Advanced hepatocellular carcinoma | Targeted therapy | sorafenib | NA | Malignant cells | -0.64311 | 0.00e+00 |
GSE115251 | Kelly cell line | Cell line | Neuroblastoma | Neuroblastoma | Targeted therapy | TAE684 | NA | Malignant cells | 0.413148 | 0.00e+00 |
GSE164897_VemCob | A375 cell line | Cell line | Melanoma | BRAFV600E-mutant melanoma | Targeted therapy | vemurafenib + combimetinib | NA | Malignant cells | -0.291695 | 0.00e+00 |
Gene symbol | motif | TF_highConf |
TMED9 | metacluster_34.4 | ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology). |
TMED9 | metacluster_34.3 | EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation). |
TMED9 | tfdimers__MD00007 | E2F1; IRF8 (directAnnotation). |
TMED9 | taipale__ELK1_full_NACTTCCGSCGGAARMN_repr | ELK1 (directAnnotation). |
TMED9 | tfdimers__MD00187 | GATA1; GATA2; GATA3; GATA4; GATA5; GATA6 (directAnnotation). |
TMED9 | transfac_pro__M05524 | ZNF362 (directAnnotation). |
TMED9 | metacluster_35.10 | ZNF681; ZNF681 (directAnnotation). |
TMED9 | transfac_pro__M06162 | ZNF93 (directAnnotation). |
TMED9 | tfdimers__MD00158 | DBP; ZNF354C (directAnnotation). |
TMED9 | kznf__ZNF25_Imbeault2017_RP_ChIP-seq | ZNF25 (directAnnotation). |
TMED9 | tfdimers__MD00143 | IKZF1; MZF1 (directAnnotation). |
TMED9 | tfdimers__MD00515 | ARID3A; KLF4 (directAnnotation). |
TMED9 | transfac_pro__M06129 | GLI4 (directAnnotation). |
TMED9 | hocomoco__HSF1_MOUSE.H11MO.1.A | HSF1 (inferredBy_Orthology). |
TMED9 | taipale_tf_pairs__GCM2_DLX2_RTRCGGGNNNNNTAATTR_CAP_repr | DLX2; GCM2 (directAnnotation). |
TMED9 | transfac_pro__M05482 | ZNF202 (directAnnotation). |
TMED9 | kznf__ZNF384_Schmitges2016_RCADE | ZNF384 (directAnnotation). |
TMED9 | metacluster_119.2 | CCNT2; GATA1; GATA1; GATA1; GATA1; GATA2; GATA2; GATA2; NCOA1; TAL1; TAL1; TAL1; TAL1; ZNF823 (directAnnotation). GATA1; TAL1; TAL1; TAL1; TAL1 (inferredBy_Orthology). |
TMED9 | tfdimers__MD00051 | GABPA; STAT6 (directAnnotation). |
TMED9 | transfac_pro__M08190 | AR (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
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