Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMED5

Summary for TMED5

Gene information	Gene symbol	TMED5
	Ensembl ID	ENSG00000117500
	Entrez ID	50999
	Gene name	transmembrane p24 trafficking protein 5
	Synonyms	CGI-100\|p24g2\|p24gamma2
	Gene type	protein_coding
	UniProtAcc	Q9Y3A6

Top

Dataset with differentially expressed gene: TMED5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.335151	5.57e-24
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.383904	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.295471	0.00e+00

Top

Expression of TMED5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to TMED5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating TMED5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMED5	hsa-miR-590-3p	99.8932	NM_016040
TMED5	hsa-miR-23b-3p	99.6959	NM_016040
TMED5	hsa-miR-23a-3p	99.6959	NM_016040
TMED5	hsa-miR-23c	99.6959	NM_016040
TMED5	hsa-miR-4282	99.0099	NM_016040
TMED5	hsa-miR-153-5p	98.6406	NM_016040
TMED5	hsa-miR-4775	98.5982	NM_016040
TMED5	hsa-miR-548c-3p	97.8436	NM_001167830
TMED5	hsa-miR-411-3p	96.7017	NM_016040
TMED5	hsa-miR-379-3p	96.7017	NM_016040
TMED5	hsa-miR-4328	94.1362	NM_001167830
TMED5	hsa-miR-335-3p	94.1025	NM_001167830
TMED5	hsa-miR-3658	93.7527	NM_016040
TMED5	hsa-miR-4666a-5p	92.6689	NM_016040
TMED5	hsa-miR-371b-5p	91.9735	NM_001167830
TMED5	hsa-miR-373-5p	91.9735	NM_001167830
TMED5	hsa-miR-616-5p	91.9735	NM_001167830
TMED5	hsa-miR-338-5p	91.1777	NM_016040
TMED5	hsa-miR-544a	90.6955	NM_016040
TMED5	hsa-miR-1468-3p	90.6104	NM_016040
TMED5	hsa-miR-3168	90.4217	NM_001167830
TMED5	hsa-miR-4795-3p	89.585	NM_001167830
TMED5	hsa-miR-3163	89.4345	NM_001167830
TMED5	hsa-miR-4495	89.2936	NM_016040
TMED5	hsa-miR-3143	88.5999	NM_016040
TMED5	hsa-miR-943	87.804	NM_016040
TMED5	hsa-miR-194-5p	87.7138	NM_016040
TMED5	hsa-miR-5582-3p	87.3075	NM_016040
TMED5	hsa-miR-6083	85.6206	NM_016040
TMED5	hsa-miR-578	85.5296	NM_001167830
TMED5	hsa-miR-6861-5p	85.12	NM_016040
TMED5	hsa-miR-133a-5p	84.6578	NM_016040
TMED5	hsa-miR-95-5p	84.0093	NM_016040
TMED5	hsa-miR-6502-3p	83.1969	NM_001167830
TMED5	hsa-miR-374a-5p	83.0795	NM_016040
TMED5	hsa-miR-374b-5p	83.065	NM_016040
TMED5	hsa-miR-4777-5p	83.0511	NM_016040
TMED5	hsa-miR-216b-5p	82.995	NM_016040
TMED5	hsa-miR-548ar-3p	82.7546	NM_016040
TMED5	hsa-miR-3646	82.7532	NM_016040
TMED5	hsa-miR-548aw	82.1716	NM_016040
TMED5	hsa-miR-548f-3p	81.2334	NM_016040
TMED5	hsa-miR-548a-3p	81.2334	NM_016040
TMED5	hsa-miR-7151-5p	80.2223	NM_016040

Page: 1

Top

Motifs and transcription factors (TFs) regulating TMED5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMED5	transfac_pro__M05798	ZNF517 (directAnnotation).
TMED5	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."