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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMCC2

Summary for TMCC2

Gene information	Gene symbol	TMCC2
	Ensembl ID	ENSG00000133069
	Entrez ID	9911
	Gene name	transmembrane and coiled-coil domain family 2
	Synonyms	FLJ38497\|HUCEP11
	Gene type	protein_coding
	UniProtAcc	O75069

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Dataset with differentially expressed gene: TMCC2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	0.303534	1.05e-21
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	1.13269	0.00e+00

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Expression of TMCC2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMCC2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMCC2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMCC2	hsa-miR-4505	94.0669	NM_001242925
TMCC2	hsa-miR-3121-3p	94.0068	NM_001242925
TMCC2	hsa-miR-5787	93.6689	NM_001242925
TMCC2	hsa-miR-4516	92.9832	NM_001242925
TMCC2	hsa-miR-5692a	92.2923	NM_001242925
TMCC2	hsa-miR-6892-3p	91.0506	NM_001242925
TMCC2	hsa-miR-3183	91.0066	NM_001242925
TMCC2	hsa-miR-4254	90.8528	NM_001242925
TMCC2	hsa-miR-6829-5p	89.9734	NM_001242925
TMCC2	hsa-miR-4723-3p	89.8806	NM_001242925
TMCC2	hsa-miR-6769b-3p	89.8806	NM_001242925
TMCC2	hsa-miR-670-5p	89.5676	NM_001242925
TMCC2	hsa-miR-345-3p	88.447	NM_001242925
TMCC2	hsa-miR-5571-3p	87.7331	NM_001242925
TMCC2	hsa-miR-6822-5p	87.4968	NM_001242925
TMCC2	hsa-miR-6750-5p	87.4968	NM_001242925
TMCC2	hsa-miR-5703	87.3407	NM_001242925
TMCC2	hsa-miR-4434	87.3407	NM_001242925
TMCC2	hsa-miR-6721-5p	84.629	NM_001242925
TMCC2	hsa-miR-4441	84.5186	NM_001242925
TMCC2	hsa-miR-510-3p	84.0075	NM_001242925
TMCC2	hsa-miR-4692	82.3947	NM_001242925
TMCC2	hsa-miR-4514	82.3947	NM_001242925
TMCC2	hsa-miR-1972	81.4407	NM_001242925
TMCC2	hsa-miR-1324	81.0155	NM_001242925
TMCC2	hsa-miR-4694-3p	80.091	NM_001242925

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Motifs and transcription factors (TFs) regulating TMCC2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMCC2	metacluster_119.2	CCNT2; GATA1; GATA1; GATA1; GATA1; GATA2; GATA2; GATA2; NCOA1; TAL1; TAL1; TAL1; TAL1; ZNF823 (directAnnotation). GATA1; TAL1; TAL1; TAL1; TAL1 (inferredBy_Orthology).
TMCC2	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP	ELK1; TBX21 (directAnnotation).
TMCC2	tfdimers__MD00046	GATA1; GATA2; GATA3; GATA4; GATA5; GATA6; SMAD4 (directAnnotation).
TMCC2	jaspar__MA1522.1	MAZ (directAnnotation).
TMCC2	metacluster_127.3	FOXO1; FOXO3; FOXO4 (directAnnotation).
TMCC2	transfac_pro__M06362	ZNF730 (directAnnotation).
TMCC2	metacluster_143.13	ZBTB7A (directAnnotation).
TMCC2	transfac_pro__M01968	FOXO1 (directAnnotation).
TMCC2	transfac_pro__M05845	ZSCAN29 (directAnnotation).
TMCC2	taipale__NR4A2_full_AGGTCANNNNNTGACCT_repr	NR4A2 (directAnnotation).
TMCC2	transfac_pro__M06277	ZNF404 (directAnnotation).
TMCC2	metacluster_63.3	RFX1; RFX2; RFX3; RFX3; RFX3; RFX4; RFX4 (directAnnotation). RFX1; RFX1; RFX2; RFX2; RFX2; RFX3; RFX3; RFX4; RFX4; RFX6; RFX6; RFX6; RFX8; RFX8 (inferredBy_Orthology).
TMCC2	transfac_pro__M06108	ZNF43 (directAnnotation).
TMCC2	transfac_pro__M06408	ZSCAN30 (directAnnotation).
TMCC2	metacluster_44.9	NKX2-2 (directAnnotation).
TMCC2	transfac_pro__M06805	ZNF280D (inferredBy_Orthology).
TMCC2	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
TMCC2	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
TMCC2	metacluster_106.2	ZBTB32 (directAnnotation).
TMCC2	metacluster_27.9	ZSCAN31 (directAnnotation).
TMCC2	metacluster_143.1	ZSCAN31 (directAnnotation).
TMCC2	tfdimers__MD00102	RUNX3; YY2 (directAnnotation).
TMCC2	transfac_pro__M06294	ZNF805 (directAnnotation).
TMCC2	metacluster_180.3	ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6B; ATF7; ATF7; BACH2; BATF3; BATF3; CREB1; CREB1; CREB3; FOSL1; FOSL2; JDP2; JUN; JUN; JUN; JUND; JUND; XBP1; ZBTB21 (directAnnotation). JDP2; JDP2; JUND (inferredBy_Orthology).
TMCC2	metacluster_168.18	ZNF214; ZNF239; ZNF45; ZNF696 (directAnnotation).
TMCC2	metacluster_155.8	ZFP82 (directAnnotation).
TMCC2	metacluster_5.1	HIVEP1; HIVEP1; NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; NFKB2; NFKB2; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELB; RELB (directAnnotation). NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; REL; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELB; RELB; RELB (inferredBy_Orthology).
TMCC2	dbtfbs__E4F1_K562_ENCSR731LHZ_merged_N1	E4F1 (directAnnotation).
TMCC2	transfac_pro__M04785	RAD21 (directAnnotation).
TMCC2	metacluster_111.5	E4F1; E4F1 (directAnnotation).
TMCC2	transfac_pro__M06118	ZNF23 (directAnnotation).
TMCC2	metacluster_131.6	EGR2; EGR4 (directAnnotation). EGR2; EGR3 (inferredBy_Orthology).
TMCC2	transfac_pro__M05506	ZSCAN16 (directAnnotation).
TMCC2	transfac_pro__M06062	ZNF623 (directAnnotation).
TMCC2	transfac_pro__M01239	RELA (directAnnotation).
TMCC2	tfdimers__MD00410	HMGA1; HMGA2; KLF4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."