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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMCC1

Summary for TMCC1

Gene information	Gene symbol	TMCC1
	Ensembl ID	ENSG00000172765
	Entrez ID	23023
	Gene name	transmembrane and coiled-coil domain family 1
	Synonyms	KIAA0779
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TMCC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.305371	2.20e-29

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Expression of TMCC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMCC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMCC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMCC1	hsa-miR-6885-3p	98.5161	NM_001017395
TMCC1	hsa-miR-4668-3p	98.1187	NM_001128224
TMCC1	hsa-miR-1-3p	97.3188	NM_001128224
TMCC1	hsa-miR-206	97.3188	NM_001128224
TMCC1	hsa-miR-27b-3p	97.2811	NM_001128224
TMCC1	hsa-miR-27a-3p	97.2811	NM_001128224
TMCC1	hsa-miR-9985	97.2811	NM_001128224
TMCC1	hsa-miR-613	96.2335	NM_001128224
TMCC1	hsa-miR-651-3p	95.4821	NM_001128224
TMCC1	hsa-miR-659-3p	95.3116	NM_001128224
TMCC1	hsa-miR-7110-3p	95.1143	NM_001128224
TMCC1	hsa-miR-449b-3p	95.0317	NM_001128224
TMCC1	hsa-miR-646	94.3923	NM_001128224
TMCC1	hsa-miR-190b-3p	94.0457	NM_001017395
TMCC1	hsa-miR-513a-5p	93.9236	NM_001128224
TMCC1	hsa-miR-1297	93.7979	NM_001128224
TMCC1	hsa-miR-589-3p	93.5494	NM_001128224
TMCC1	hsa-miR-4524a-5p	93.1024	NM_001128224
TMCC1	hsa-miR-4524b-5p	93.1024	NM_001128224
TMCC1	hsa-miR-26b-5p	92.772	NM_001128224
TMCC1	hsa-miR-26a-5p	92.772	NM_001128224
TMCC1	hsa-miR-466	92.4596	NM_001017395
TMCC1	hsa-miR-6814-5p	92.1762	NM_001017395
TMCC1	hsa-miR-1185-1-3p	91.8709	NM_001128224
TMCC1	hsa-let-7f-2-3p	91.8709	NM_001128224
TMCC1	hsa-miR-1185-2-3p	91.8709	NM_001128224
TMCC1	hsa-miR-195-5p	91.8449	NM_001128224
TMCC1	hsa-miR-16-5p	91.8449	NM_001128224
TMCC1	hsa-miR-15a-5p	91.0945	NM_001128224
TMCC1	hsa-miR-15b-5p	91.0945	NM_001128224
TMCC1	hsa-miR-4424	90.6943	NM_001128224
TMCC1	hsa-miR-221-3p	90.6942	NM_001017395
TMCC1	hsa-miR-222-3p	90.6942	NM_001017395
TMCC1	hsa-miR-548d-3p	90.6885	NM_001128224
TMCC1	hsa-miR-548az-5p	90.4715	NM_001128224
TMCC1	hsa-miR-548t-5p	90.4715	NM_001128224
TMCC1	hsa-miR-6081	90.2431	NM_001128224
TMCC1	hsa-miR-4495	90.168	NM_001128224
TMCC1	hsa-miR-3169	90.0709	NM_001128224
TMCC1	hsa-miR-1183	89.9503	NM_001128224
TMCC1	hsa-miR-517b-3p	89.906	NM_001017395
TMCC1	hsa-miR-517a-3p	89.906	NM_001017395
TMCC1	hsa-miR-517c-3p	89.906	NM_001017395
TMCC1	hsa-miR-424-5p	89.8107	NM_001128224
TMCC1	hsa-miR-497-5p	89.8107	NM_001128224
TMCC1	hsa-miR-4465	89.6959	NM_001128224
TMCC1	hsa-miR-548z	89.6806	NM_001128224
TMCC1	hsa-miR-548bb-3p	89.6806	NM_001128224
TMCC1	hsa-miR-548ac	89.6806	NM_001128224
TMCC1	hsa-miR-548h-3p	89.6806	NM_001128224

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Motifs and transcription factors (TFs) regulating TMCC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMCC1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TMCC1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TMCC1	metacluster_7.13	ZFX (directAnnotation).
TMCC1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TMCC1	cisbp__M00968	MTF2 (directAnnotation).
TMCC1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TMCC1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
TMCC1	cisbp__M00341	PAX6 (directAnnotation).
TMCC1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
TMCC1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TMCC1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
TMCC1	cisbp__M00788	ZFY (inferredBy_Orthology).
TMCC1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
TMCC1	metacluster_175.1	ZNF283 (directAnnotation).
TMCC1	hdpi__ZNF304	ZNF304 (directAnnotation).
TMCC1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
TMCC1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
TMCC1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TMCC1	transfac_pro__M01199	TRIM28 (directAnnotation).
TMCC1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
TMCC1	metacluster_151.2	ZNF23 (directAnnotation).
TMCC1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TMCC1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TMCC1	transfac_pro__M03806	ZBTB7C (directAnnotation).
TMCC1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."