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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TM9SF2

Summary for TM9SF2

Gene information	Gene symbol	TM9SF2
	Ensembl ID	ENSG00000125304
	Entrez ID	9375
	Gene name	transmembrane 9 superfamily member 2
	Synonyms	P76
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TM9SF2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.514674	9.13e-03
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.386004	3.79e-19
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.303933	1.12e-42
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.280616	0.00e+00

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Expression of TM9SF2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TM9SF2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TM9SF2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TM9SF2	hsa-miR-105-5p	98.4866	NM_004800
TM9SF2	hsa-miR-7853-5p	98.4866	NM_004800
TM9SF2	hsa-miR-1277-5p	98.3748	NM_004800
TM9SF2	hsa-miR-16-1-3p	96.7696	NM_004800
TM9SF2	hsa-miR-7-2-3p	95.3945	NM_004800
TM9SF2	hsa-miR-7-1-3p	95.3945	NM_004800
TM9SF2	hsa-miR-7153-3p	95.2521	NM_004800
TM9SF2	hsa-miR-5011-5p	95.1333	NM_004800
TM9SF2	hsa-miR-4699-3p	94.8844	NM_004800
TM9SF2	hsa-miR-4727-5p	94.7832	NM_004800
TM9SF2	hsa-miR-5692b	92.817	NM_004800
TM9SF2	hsa-miR-5692c	92.817	NM_004800
TM9SF2	hsa-miR-5582-5p	91.7564	NM_004800
TM9SF2	hsa-miR-4742-3p	91.7335	NM_004800
TM9SF2	hsa-miR-3688-3p	91.5064	NM_004800
TM9SF2	hsa-miR-4668-3p	91.1518	NM_004800
TM9SF2	hsa-miR-548f-3p	91.0456	NM_004800
TM9SF2	hsa-miR-548e-3p	91.0456	NM_004800
TM9SF2	hsa-miR-548az-3p	91.0456	NM_004800
TM9SF2	hsa-miR-548a-3p	91.0456	NM_004800
TM9SF2	hsa-miR-548bc	91.0456	NM_004800
TM9SF2	hsa-miR-4477a	90.8401	NM_004800
TM9SF2	hsa-miR-548ar-3p	90.6386	NM_004800
TM9SF2	hsa-miR-876-5p	90.6336	NM_004800
TM9SF2	hsa-miR-4769-3p	90.1188	NM_004800
TM9SF2	hsa-miR-6817-5p	90.1188	NM_004800
TM9SF2	hsa-miR-12136	89.9078	NM_004800
TM9SF2	hsa-miR-5688	89.2029	NM_004800
TM9SF2	hsa-miR-1275	89.0466	NM_004800
TM9SF2	hsa-miR-1245b-3p	86.7879	NM_004800
TM9SF2	hsa-miR-505-3p	86.7624	NM_004800
TM9SF2	hsa-miR-3167	86.7329	NM_004800
TM9SF2	hsa-miR-4665-5p	86.2769	NM_004800
TM9SF2	hsa-miR-6738-3p	86.0735	NM_004800
TM9SF2	hsa-miR-6515-3p	84.5243	NM_004800
TM9SF2	hsa-miR-495-3p	84.225	NM_004800
TM9SF2	hsa-miR-205-5p	84.116	NM_004800
TM9SF2	hsa-miR-6882-5p	84.0208	NM_004800
TM9SF2	hsa-miR-374a-5p	82.7012	NM_004800
TM9SF2	hsa-miR-4652-3p	82.5475	NM_004800
TM9SF2	hsa-miR-5589-3p	82.3036	NM_004800
TM9SF2	hsa-miR-449b-3p	82.0008	NM_004800
TM9SF2	hsa-miR-224-5p	81.5484	NM_004800
TM9SF2	hsa-miR-374b-5p	80.6793	NM_004800

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Motifs and transcription factors (TFs) regulating TM9SF2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TM9SF2	transfac_pro__M06213	ZNF267 (directAnnotation).
TM9SF2	cisbp__M00249	WT1 (directAnnotation).
TM9SF2	transfac_pro__M01122	ZNF219 (directAnnotation).
TM9SF2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TM9SF2	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
TM9SF2	transfac_public__M00491	PATZ1 (directAnnotation).
TM9SF2	tfdimers__MD00029	IKZF2; NKX3-2 (directAnnotation).
TM9SF2	kznf__ZNF343_Imbeault2017_RP_RCADE	ZNF343 (directAnnotation).
TM9SF2	transfac_pro__M06342	ZNF329 (inferredBy_Orthology).
TM9SF2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
TM9SF2	metacluster_173.2	ATF3; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; BATF3; CREB3; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L4; XBP1; XBP1; XBP1; XBP1 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."