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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TM2D3

Summary for TM2D3

Gene information	Gene symbol	TM2D3
	Ensembl ID	ENSG00000184277
	Entrez ID	80213
	Gene name	TM2 domain containing 3
	Synonyms	BLP2\|FLJ22604
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TM2D3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.511813	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.491585	0.00e+00

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Expression of TM2D3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TM2D3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TM2D3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TM2D3	hsa-miR-4718	97.4225	NM_078474
TM2D3	hsa-miR-4742-5p	94.0113	NM_078474
TM2D3	hsa-miR-1297	92.9731	NM_001307960
TM2D3	hsa-miR-17-3p	92.8733	NM_078474
TM2D3	hsa-miR-6804-5p	92.7918	NM_001307960
TM2D3	hsa-miR-4778-3p	92.099	NM_001307960
TM2D3	hsa-miR-4498	92.0683	NM_078474
TM2D3	hsa-miR-512-3p	91.2759	NM_001307960
TM2D3	hsa-miR-548aj-3p	90.3464	NM_078474
TM2D3	hsa-miR-548x-3p	90.3464	NM_078474
TM2D3	hsa-miR-4492	89.8282	NM_078474
TM2D3	hsa-miR-26a-5p	89.3277	NM_001307960
TM2D3	hsa-miR-26b-5p	89.3277	NM_001307960
TM2D3	hsa-miR-4999-5p	87.4382	NM_078474
TM2D3	hsa-miR-548ac	86.6168	NM_078474
TM2D3	hsa-miR-548d-3p	86.6168	NM_078474
TM2D3	hsa-miR-548j-3p	86.6168	NM_078474
TM2D3	hsa-miR-548h-3p	86.6168	NM_078474
TM2D3	hsa-miR-548ae-3p	86.6168	NM_078474
TM2D3	hsa-miR-548aq-3p	86.6168	NM_078474
TM2D3	hsa-miR-548ah-3p	86.6168	NM_078474
TM2D3	hsa-miR-548am-3p	86.6168	NM_078474
TM2D3	hsa-miR-548bb-3p	86.6168	NM_078474
TM2D3	hsa-miR-548z	86.6168	NM_078474
TM2D3	hsa-miR-1537-5p	86.6053	NM_078474
TM2D3	hsa-miR-762	85.9109	NM_078474
TM2D3	hsa-miR-5001-5p	85.9109	NM_078474
TM2D3	hsa-miR-4465	84.0331	NM_001307960
TM2D3	hsa-miR-4775	83.7694	NM_078474
TM2D3	hsa-miR-4493	82.4504	NM_001307960
TM2D3	hsa-miR-3922-5p	81.3992	NM_078474
TM2D3	hsa-miR-502-5p	80.7885	NM_001307960
TM2D3	hsa-miR-3691-5p	80.4136	NM_001307960

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Motifs and transcription factors (TFs) regulating TM2D3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TM2D3	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
TM2D3	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
TM2D3	cisbp__M08198	ELF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."