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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TLN1

Summary for TLN1

Gene information	Gene symbol	TLN1
	Ensembl ID	ENSG00000137076
	Entrez ID	7094
	Gene name	talin 1
	Synonyms	ILWEQ\|TLN
	Gene type	protein_coding
	UniProtAcc	Q9Y490

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Dataset with differentially expressed gene: TLN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.259194	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.449297	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.556186	5.10e-04
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	CD4+ T cells	0.310725	6.18e-08
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.3079	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.393839	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.31116	1.31e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	-0.304484	6.10e-06
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.519443	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.344559	0.00e+00

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Expression of TLN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TLN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TLN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TLN1	hsa-miR-4731-5p	97.8666	NM_006289
TLN1	hsa-miR-6715b-5p	95.8549	NM_006289
TLN1	hsa-miR-153-5p	95.7041	NM_006289
TLN1	hsa-miR-20a-3p	94.0609	NM_006289
TLN1	hsa-miR-4269	93.7443	NM_006289
TLN1	hsa-miR-6721-5p	90.2113	NM_006289
TLN1	hsa-miR-6763-5p	89.3164	NM_006289
TLN1	hsa-miR-6503-5p	89.2004	NM_006289
TLN1	hsa-miR-4527	89.2004	NM_006289
TLN1	hsa-miR-1207-5p	88.7023	NM_006289
TLN1	hsa-miR-432-5p	87.8002	NM_006289
TLN1	hsa-miR-5572	86.8772	NM_006289
TLN1	hsa-miR-124-3p	86.3666	NM_006289
TLN1	hsa-miR-506-3p	86.3666	NM_006289
TLN1	hsa-miR-450a-2-3p	85.8269	NM_006289
TLN1	hsa-miR-3150a-3p	85.3323	NM_006289
TLN1	hsa-miR-4736	84.7991	NM_006289
TLN1	hsa-miR-200c-3p	84.2203	NM_006289
TLN1	hsa-miR-200b-3p	84.2203	NM_006289
TLN1	hsa-miR-429	84.2203	NM_006289
TLN1	hsa-miR-4763-3p	83.0768	NM_006289
TLN1	hsa-miR-514a-5p	81.6828	NM_006289
TLN1	hsa-miR-330-5p	81.5177	NM_006289
TLN1	hsa-miR-4260	81.2727	NM_006289
TLN1	hsa-miR-7155-5p	80.5176	NM_006289

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Motifs and transcription factors (TFs) regulating TLN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TLN1	metacluster_7.13	ZFX (directAnnotation).
TLN1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
TLN1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
TLN1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TLN1	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
TLN1	transfac_pro__M02843	BBX (inferredBy_Orthology).
TLN1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
TLN1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
TLN1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
TLN1	metacluster_3.14	WT1; WT1 (directAnnotation).
TLN1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TLN1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
TLN1	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
TLN1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
TLN1	jaspar__MA1483.2	ELF2 (directAnnotation).
TLN1	dbtfbs__WT1_HEK293_ENCSR966PJJ_merged_N1	WT1 (directAnnotation).
TLN1	metacluster_166.5	ERG; ETV2; FLI1 (directAnnotation).
TLN1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
TLN1	jaspar__MA1946.1	FOXI1 (directAnnotation).
TLN1	tfdimers__MD00190	ARID3A; WT1 (directAnnotation).
TLN1	metacluster_132.4	MEF2B; MEF2B; MEF2B; MEF2B; MEF2C; MEF2C; MEF2D; MEF2D; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF (directAnnotation). SRF; SRF; SRF; SRF (inferredBy_Orthology).
TLN1	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
TLN1	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
TLN1	tfdimers__MD00475	FOS; FOSB; FOSL1; FOSL2; JUN; JUNB; JUND; ZNF333 (directAnnotation).
TLN1	transfac_pro__M07392	PITX3 (directAnnotation).
TLN1	tfdimers__MD00147	ELF5; TFAP2C (directAnnotation).
TLN1	tfdimers__MD00362	ARID3A; BCL6 (directAnnotation).
TLN1	metacluster_22.13	MAFK (inferredBy_Orthology).
TLN1	metacluster_22.19	NFE2 (directAnnotation).
TLN1	transfac_pro__M01229	GTF2IRD1 (directAnnotation).
TLN1	metacluster_22.20	MAFG (directAnnotation).
TLN1	transfac_pro__M05427	ZNF516 (directAnnotation).
TLN1	metacluster_22.32	NFE2L2 (directAnnotation).
TLN1	hdpi__PQBP1	PQBP1 (directAnnotation).
TLN1	homer__TRCATTCCAG_TEAD3	TEAD3 (directAnnotation).
TLN1	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
TLN1	metacluster_171.4	TEAD1; TEAD1; TEAD1; TEAD1; TEAD3; TEAD3; TEAD4; TEAD4; TEAD4; TEAD4 (directAnnotation). TEAD1; TEAD2; TEAD4; TEAD4 (inferredBy_Orthology).
TLN1	metacluster_22.28	BACH1 (directAnnotation).
TLN1	kznf__ZNF805_Imbeault2017_RP_RCADE	ZNF805 (directAnnotation).
TLN1	metacluster_22.25	NFE2L2 (directAnnotation).
TLN1	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
TLN1	transfac_pro__M06342	ZNF329 (inferredBy_Orthology).
TLN1	kznf__ZNF480_Imbeault2017_OM_RCADE	ZNF480 (directAnnotation).
TLN1	metacluster_29.1	STAT4; STAT5A; STAT5A; STAT5B (directAnnotation). STAT5B; STAT5B (inferredBy_Orthology).
TLN1	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
TLN1	transfac_pro__M01783	SP2 (directAnnotation).
TLN1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
TLN1	cisbp__M00788	ZFY (inferredBy_Orthology).
TLN1	transfac_pro__M12697	ZNF142 (directAnnotation).
TLN1	jaspar__MA1952.1	FOXJ2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."