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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: TLK2

Summary for TLK2

Gene information	Gene symbol	TLK2
	Ensembl ID	ENSG00000146872
	Entrez ID	11011
	Gene name	tousled like kinase 2
	Synonyms	MGC44450\|PKU-ALPHA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TLK2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.257712	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.261163	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.256454	6.17e-37
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.252652	7.77e-17

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Expression of TLK2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TLK2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TLK2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TLK2	hsa-miR-4668-5p	99.1463	NM_001284333
TLK2	hsa-miR-548e-5p	99.0946	NM_001284333
TLK2	hsa-miR-6867-5p	98.7126	NM_001284333
TLK2	hsa-miR-4279	96.657	NM_001284333
TLK2	hsa-miR-1193	95.3045	NM_001284333
TLK2	hsa-miR-451b	94.9053	NM_001284333
TLK2	hsa-miR-4289	94.6957	NM_001284333
TLK2	hsa-miR-9985	92.2329	NM_001284333
TLK2	hsa-miR-27b-3p	92.2329	NM_001284333
TLK2	hsa-miR-27a-3p	92.2329	NM_001284333
TLK2	hsa-miR-5582-3p	90.7953	NM_001284333
TLK2	hsa-miR-3613-3p	88.9956	NM_001284333
TLK2	hsa-miR-7108-5p	88.7872	NM_001284333
TLK2	hsa-miR-3611	87.9713	NM_001284333
TLK2	hsa-miR-3148	87.6207	NM_001284333
TLK2	hsa-miR-670-3p	86.9383	NM_001284333
TLK2	hsa-miR-629-5p	86.8325	NM_001284333
TLK2	hsa-miR-3671	86.5947	NM_001284333
TLK2	hsa-miR-30a-3p	85.8014	NM_001284333
TLK2	hsa-miR-30d-3p	85.8014	NM_001284333
TLK2	hsa-miR-3688-5p	83.5441	NM_001284333
TLK2	hsa-miR-2355-5p	83.1114	NM_001284333
TLK2	hsa-miR-513a-5p	82.9975	NM_001284333
TLK2	hsa-miR-630	82.7672	NM_001284333
TLK2	hsa-miR-6765-3p	82.5043	NM_001284333
TLK2	hsa-miR-30e-3p	82.4626	NM_001284333
TLK2	hsa-miR-5688	81.4171	NM_001284333
TLK2	hsa-miR-607	80.8538	NM_001284333
TLK2	hsa-miR-8485	80.6571	NM_001284333

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Motifs and transcription factors (TFs) regulating TLK2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TLK2	metacluster_135.11	NR2C2 (directAnnotation).
TLK2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TLK2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TLK2	metacluster_7.13	ZFX (directAnnotation).
TLK2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
TLK2	cisbp__M00968	MTF2 (directAnnotation).
TLK2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
TLK2	cisbp__M00341	PAX6 (directAnnotation).
TLK2	metacluster_198.3	ZFP64 (directAnnotation).
TLK2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
TLK2	cisbp__M00788	ZFY (inferredBy_Orthology).
TLK2	hdpi__ZNF304	ZNF304 (directAnnotation).
TLK2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
TLK2	transfac_pro__M01199	TRIM28 (directAnnotation).
TLK2	metacluster_151.2	ZNF23 (directAnnotation).
TLK2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TLK2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
TLK2	transfac_pro__M03806	ZBTB7C (directAnnotation).
TLK2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TLK2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
TLK2	metacluster_191.5	SPDEF (inferredBy_Orthology).
TLK2	transfac_pro__M04916	TAF1 (directAnnotation).
TLK2	transfac_pro__M07310	SP5 (directAnnotation).
TLK2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
TLK2	metacluster_182.10	ZFX (directAnnotation).
TLK2	hocomoco__ZFX_MOUSE.H11MO.1.B	ZFY (inferredBy_Orthology).
TLK2	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
TLK2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
TLK2	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."