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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TIPRL

Summary for TIPRL

Gene information	Gene symbol	TIPRL
	Ensembl ID	ENSG00000143155
	Entrez ID	261726
	Gene name	TOR signaling pathway regulator
	Synonyms	dJ69E11.3\|MGC3794\|TIP41\|TIPRL1
	Gene type	protein_coding
	UniProtAcc	O75663

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Dataset with differentially expressed gene: TIPRL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.283132	2.00e-14
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.324927	2.31e-11
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.38358	1.77e-22
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.298848	2.80e-10
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.513029	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.334746	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.360082	0.00e+00

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Expression of TIPRL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TIPRL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TIPRL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TIPRL	hsa-miR-8485	99.7429	NM_152902
TIPRL	hsa-miR-6867-5p	99.6305	NM_152902
TIPRL	hsa-miR-5571-5p	99.4899	NM_152902
TIPRL	hsa-miR-519e-5p	96.8076	NM_152902
TIPRL	hsa-miR-515-5p	96.8076	NM_152902
TIPRL	hsa-miR-3174	94.3215	NM_152902
TIPRL	hsa-miR-6128	93.6195	NM_152902
TIPRL	hsa-miR-4764-3p	93.1802	NM_152902
TIPRL	hsa-miR-4279	92.9314	NM_152902
TIPRL	hsa-miR-4282	89.5553	NM_152902
TIPRL	hsa-miR-3163	87.8267	NM_152902
TIPRL	hsa-miR-7154-3p	86.5599	NM_152902
TIPRL	hsa-miR-4298	86.1255	NM_152902
TIPRL	hsa-miR-9902	85.8436	NM_152902
TIPRL	hsa-miR-6747-3p	85.227	NM_152902
TIPRL	hsa-miR-1302	84.8498	NM_152902
TIPRL	hsa-miR-3129-3p	84.7754	NM_152902
TIPRL	hsa-miR-5583-5p	84.7754	NM_152902
TIPRL	hsa-miR-548v	84.4068	NM_152902
TIPRL	hsa-miR-498-3p	84.1822	NM_152902
TIPRL	hsa-miR-513a-3p	83.9329	NM_152902
TIPRL	hsa-miR-513c-3p	83.9329	NM_152902
TIPRL	hsa-miR-138-1-3p	83.4368	NM_001031800
TIPRL	hsa-miR-4477b	83.3851	NM_152902
TIPRL	hsa-miR-7856-5p	81.893	NM_152902
TIPRL	hsa-miR-513c-5p	81.5953	NM_152902
TIPRL	hsa-miR-514b-5p	81.5953	NM_152902
TIPRL	hsa-miR-32-3p	80.9363	NM_152902
TIPRL	hsa-miR-5011-3p	80.7748	NM_152902
TIPRL	hsa-miR-6792-5p	80.3941	NM_152902
TIPRL	hsa-miR-501-3p	80.3135	NM_152902
TIPRL	hsa-miR-502-3p	80.3135	NM_152902
TIPRL	hsa-miR-371b-5p	80.0526	NM_152902
TIPRL	hsa-miR-616-5p	80.0526	NM_152902
TIPRL	hsa-miR-373-5p	80.0526	NM_152902

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Motifs and transcription factors (TFs) regulating TIPRL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TIPRL	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
TIPRL	metacluster_151.2	ZNF23 (directAnnotation).
TIPRL	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
TIPRL	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
TIPRL	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
TIPRL	hdpi__ETV4	ETV4 (directAnnotation).
TIPRL	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
TIPRL	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
TIPRL	transfac_pro__M04826	EP300 (directAnnotation).
TIPRL	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
TIPRL	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
TIPRL	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
TIPRL	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
TIPRL	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
TIPRL	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
TIPRL	jaspar__MA1483.2	ELF2 (directAnnotation).
TIPRL	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
TIPRL	swissregulon__hs__ELF2	ELF2 (directAnnotation).
TIPRL	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
TIPRL	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
TIPRL	cisbp__M02645	ETS1 (directAnnotation).
TIPRL	cisbp__M08198	ELF1 (directAnnotation).
TIPRL	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
TIPRL	hdpi__ELF2	ELF2 (directAnnotation).
TIPRL	swissregulon__hs__ELK1	ELK1 (directAnnotation).
TIPRL	metacluster_183.4	ETS1 (inferredBy_Orthology).
TIPRL	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
TIPRL	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
TIPRL	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
TIPRL	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
TIPRL	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
TIPRL	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
TIPRL	transfac_public__M00041	ATF2; JUN (directAnnotation).
TIPRL	taipale_tf_pairs__ERF_TBX21_TMACACCGGAAG_CAP	ERF; TBX21 (directAnnotation).
TIPRL	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."