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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TIAM1

Summary for TIAM1

Gene information	Gene symbol	TIAM1
	Ensembl ID	ENSG00000156299
	Entrez ID	7074
	Gene name	TIAM Rac1 associated GEF 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q13009

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Dataset with differentially expressed gene: TIAM1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.923317	2.15e-03

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Expression of TIAM1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TIAM1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TIAM1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TIAM1	hsa-miR-3163	99.774	NM_003253
TIAM1	hsa-miR-548p	97.0171	NM_003253
TIAM1	hsa-miR-6766-5p	95.8341	NM_003253
TIAM1	hsa-miR-6756-5p	95.8341	NM_003253
TIAM1	hsa-miR-6867-5p	95.7718	NM_003253
TIAM1	hsa-miR-4642	94.1129	NM_003253
TIAM1	hsa-miR-376b-3p	93.9878	NM_003253
TIAM1	hsa-miR-376a-3p	93.9878	NM_003253
TIAM1	hsa-miR-580-3p	93.2277	NM_003253
TIAM1	hsa-miR-590-5p	93.2162	NM_003253
TIAM1	hsa-miR-21-5p	93.2162	NM_003253
TIAM1	hsa-miR-4511	92.8645	NM_003253
TIAM1	hsa-miR-29a-5p	92.4932	NM_003253
TIAM1	hsa-miR-129-1-3p	92.4095	NM_003253
TIAM1	hsa-miR-129-2-3p	92.4095	NM_003253
TIAM1	hsa-miR-3942-3p	92.3739	NM_003253
TIAM1	hsa-miR-3148	92.0305	NM_003253
TIAM1	hsa-miR-3684	91.781	NM_003253
TIAM1	hsa-miR-6817-3p	91.6008	NM_003253
TIAM1	hsa-miR-340-5p	91.4265	NM_003253
TIAM1	hsa-miR-21-3p	91.3861	NM_003253
TIAM1	hsa-miR-122b-3p	91.3861	NM_003253
TIAM1	hsa-miR-10a-5p	91.3419	NM_003253
TIAM1	hsa-miR-10b-5p	91.3419	NM_003253
TIAM1	hsa-miR-20b-5p	91.3165	NM_003253
TIAM1	hsa-miR-519d-3p	91.3165	NM_003253
TIAM1	hsa-miR-106a-5p	91.3165	NM_003253
TIAM1	hsa-miR-20a-5p	91.3165	NM_003253
TIAM1	hsa-miR-93-5p	91.3165	NM_003253
TIAM1	hsa-miR-106b-5p	91.3165	NM_003253
TIAM1	hsa-miR-17-5p	91.3165	NM_003253
TIAM1	hsa-miR-141-3p	90.0469	NM_003253
TIAM1	hsa-miR-200a-3p	90.0469	NM_003253
TIAM1	hsa-miR-4533	89.016	NM_003253
TIAM1	hsa-miR-11399	88.8549	NM_003253
TIAM1	hsa-miR-3613-3p	88.8057	NM_003253
TIAM1	hsa-miR-583	88.7611	NM_003253
TIAM1	hsa-miR-526b-3p	87.4801	NM_003253
TIAM1	hsa-miR-6775-3p	87.0886	NM_003253
TIAM1	hsa-miR-1291	87.0886	NM_003253
TIAM1	hsa-miR-653-5p	86.8622	NM_003253
TIAM1	hsa-miR-372-5p	86.7906	NM_003253
TIAM1	hsa-miR-302e	85.8764	NM_003253
TIAM1	hsa-miR-938	85.6542	NM_003253
TIAM1	hsa-miR-2355-5p	85.2314	NM_003253
TIAM1	hsa-miR-1231	84.9305	NM_003253
TIAM1	hsa-miR-4659b-3p	84.9296	NM_003253
TIAM1	hsa-miR-4659a-3p	84.9296	NM_003253
TIAM1	hsa-miR-875-3p	84.8241	NM_003253
TIAM1	hsa-miR-410-3p	84.73	NM_003253

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Motifs and transcription factors (TFs) regulating TIAM1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TIAM1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
TIAM1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
TIAM1	transfac_pro__M07387	ZBTB7A (directAnnotation).
TIAM1	transfac_pro__M07436	WT1 (directAnnotation).
TIAM1	transfac_pro__M00716	ZBTB14 (directAnnotation).
TIAM1	hdpi__HIP2	UBE2K (directAnnotation).
TIAM1	transfac_pro__M04893	TAF1 (directAnnotation).
TIAM1	transfac_pro__M03876	ZBTB33 (directAnnotation).
TIAM1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TIAM1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
TIAM1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."