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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TIA1

Summary for TIA1

Gene information	Gene symbol	TIA1
	Ensembl ID	ENSG00000116001
	Entrez ID	7072
	Gene name	TIA1 cytotoxic granule associated RNA binding protein
	Synonyms	TIA-1
	Gene type	protein_coding
	UniProtAcc	P31483

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Dataset with differentially expressed gene: TIA1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.418037	2.31e-26

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Expression of TIA1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TIA1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TIA1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TIA1	hsa-miR-4251	97.5724	NM_022173
TIA1	hsa-miR-3691-5p	97.2922	NM_022173
TIA1	hsa-miR-153-5p	96.9328	NM_022173
TIA1	hsa-miR-493-5p	95.5747	NM_022173
TIA1	hsa-miR-4666a-5p	94.5178	NM_022173
TIA1	hsa-miR-4639-3p	94.2017	NM_022173
TIA1	hsa-miR-2682-3p	94.0978	NM_022173
TIA1	hsa-miR-6781-3p	93.9026	NM_022173
TIA1	hsa-miR-3133	92.6063	NM_022173
TIA1	hsa-miR-605-3p	92.3638	NM_022173
TIA1	hsa-miR-433-3p	92.202	NM_022173
TIA1	hsa-miR-342-3p	89.4046	NM_022173
TIA1	hsa-miR-320a-5p	89.1599	NM_022173
TIA1	hsa-miR-34b-3p	88.1387	NM_022173
TIA1	hsa-miR-19a-3p	87.5959	NM_022173
TIA1	hsa-miR-19b-3p	87.5959	NM_022173
TIA1	hsa-miR-4698	86.7311	NM_022173
TIA1	hsa-miR-4720-3p	86.6163	NM_022173
TIA1	hsa-miR-510-3p	85.2534	NM_022173
TIA1	hsa-miR-6126	84.035	NM_022173
TIA1	hsa-miR-5001-3p	83.4269	NM_022173
TIA1	hsa-miR-6128	83.1983	NM_022173
TIA1	hsa-miR-1250-3p	81.8451	NM_022173
TIA1	hsa-miR-548x-3p	80.6367	NM_022173
TIA1	hsa-miR-548aj-3p	80.6367	NM_022173
TIA1	hsa-miR-7161-5p	80.5489	NM_022173

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Motifs and transcription factors (TFs) regulating TIA1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TIA1	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
TIA1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
TIA1	transfac_pro__M04826	EP300 (directAnnotation).
TIA1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
TIA1	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
TIA1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
TIA1	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
TIA1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TIA1	jaspar__MA0748.2	YY2 (directAnnotation).
TIA1	transfac_pro__M01298	MECP2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."