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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: THUMPD1

Summary for THUMPD1

Gene information	Gene symbol	THUMPD1
	Ensembl ID	ENSG00000066654
	Entrez ID	55623
	Gene name	THUMP domain containing 1
	Synonyms	FLJ20274\|Tan1
	Gene type	protein_coding
	UniProtAcc	Q9NXG2

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Dataset with differentially expressed gene: THUMPD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.424108	2.56e-34
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.400843	4.77e-33

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Expression of THUMPD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to THUMPD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating THUMPD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
THUMPD1	hsa-miR-3124-3p	98.0048	NM_001304550
THUMPD1	hsa-miR-153-5p	93.0303	NM_017736
THUMPD1	hsa-miR-3143	93.0283	NM_001304550
THUMPD1	hsa-miR-548az-3p	92.6693	NM_017736
THUMPD1	hsa-miR-548f-3p	92.6693	NM_017736
THUMPD1	hsa-miR-548e-3p	92.6693	NM_017736
THUMPD1	hsa-miR-548a-3p	92.6693	NM_017736
THUMPD1	hsa-miR-548bc	92.6693	NM_017736
THUMPD1	hsa-miR-548ar-3p	92.6561	NM_017736
THUMPD1	hsa-miR-873-5p	92.2948	NM_001304550
THUMPD1	hsa-miR-1200	92.0082	NM_001304550
THUMPD1	hsa-miR-543	91.6537	NM_017736
THUMPD1	hsa-miR-4697-3p	91.3483	NM_001304550
THUMPD1	hsa-miR-361-5p	91.2943	NM_001304550
THUMPD1	hsa-miR-4297	89.8172	NM_001304550
THUMPD1	hsa-miR-3919	89.7236	NM_001304550
THUMPD1	hsa-miR-501-5p	88.5076	NM_001304550
THUMPD1	hsa-miR-9983-3p	87.9922	NM_017736
THUMPD1	hsa-miR-129-5p	87.8838	NM_017736
THUMPD1	hsa-miR-7974	86.4131	NM_001304550
THUMPD1	hsa-miR-4756-3p	85.7716	NM_001304550
THUMPD1	hsa-miR-8485	85.2969	NM_017736
THUMPD1	hsa-miR-3160-5p	84.8305	NM_017736
THUMPD1	hsa-miR-4799-5p	84.6463	NM_001304550
THUMPD1	hsa-miR-138-1-3p	84.6462	NM_017736
THUMPD1	hsa-miR-6750-5p	84.5478	NM_001304550
THUMPD1	hsa-miR-6822-5p	84.5478	NM_001304550
THUMPD1	hsa-miR-12122	83.7929	NM_001304550
THUMPD1	hsa-miR-432-5p	83.7792	NM_001304550
THUMPD1	hsa-miR-3680-3p	83.6801	NM_001304550
THUMPD1	hsa-miR-580-3p	83.3337	NM_001304550
THUMPD1	hsa-miR-548g-3p	83.0836	NM_017736
THUMPD1	hsa-miR-4729	82.9992	NM_001304550
THUMPD1	hsa-miR-449c-3p	82.4691	NM_001304550
THUMPD1	hsa-miR-3941	82.4402	NM_017736
THUMPD1	hsa-miR-5581-5p	81.6542	NM_001304550
THUMPD1	hsa-miR-6881-3p	80.8425	NM_001304550
THUMPD1	hsa-miR-5582-3p	80.7076	NM_017736
THUMPD1	hsa-miR-8063	80.5666	NM_001304550
THUMPD1	hsa-miR-5003-3p	80.4373	NM_001304550
THUMPD1	hsa-miR-548p	80.3533	NM_001304550

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Motifs and transcription factors (TFs) regulating THUMPD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
THUMPD1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."