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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: THAP1

Summary for THAP1

Gene information	Gene symbol	THAP1
	Ensembl ID	ENSG00000131931
	Entrez ID	55145
	Gene name	THAP domain containing 1
	Synonyms	4833431A01Rik\|DYT6\|FLJ10477
	Gene type	protein_coding
	UniProtAcc	Q9NVV9

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Dataset with differentially expressed gene: THAP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.441421	0.00e+00

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Expression of THAP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to THAP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating THAP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
THAP1	hsa-miR-5011-5p	99.5934	NM_018105
THAP1	hsa-miR-144-3p	98.0587	NM_199003
THAP1	hsa-miR-190a-3p	98.0137	NM_018105
THAP1	hsa-miR-590-3p	96.9582	NM_018105
THAP1	hsa-miR-5580-3p	96.1848	NM_199003
THAP1	hsa-miR-4775	95.4476	NM_199003
THAP1	hsa-miR-4735-5p	95.3882	NM_018105
THAP1	hsa-miR-4495	93.4759	NM_018105
THAP1	hsa-miR-3613-3p	93.4197	NM_199003
THAP1	hsa-miR-548n	92.2957	NM_018105
THAP1	hsa-miR-200c-3p	91.5846	NM_199003
THAP1	hsa-miR-200b-3p	91.5846	NM_199003
THAP1	hsa-miR-429	91.5846	NM_199003
THAP1	hsa-miR-4703-5p	91.4336	NM_018105
THAP1	hsa-miR-676-5p	90.9654	NM_199003
THAP1	hsa-miR-153-5p	89.9423	NM_199003
THAP1	hsa-miR-101-3p	89.8006	NM_018105
THAP1	hsa-miR-12119	89.7601	NM_199003
THAP1	hsa-miR-8084	88.7472	NM_199003
THAP1	hsa-miR-4438	88.2501	NM_018105
THAP1	hsa-miR-3646	88.0991	NM_199003
THAP1	hsa-miR-3942-5p	87.7866	NM_018105
THAP1	hsa-miR-7162-3p	87.5791	NM_199003
THAP1	hsa-miR-29a-5p	87.4608	NM_018105
THAP1	hsa-miR-2053	85.8685	NM_018105
THAP1	hsa-miR-1228-3p	84.2476	NM_018105
THAP1	hsa-miR-548t-5p	83.4281	NM_018105
THAP1	hsa-miR-548az-5p	83.4281	NM_018105
THAP1	hsa-miR-6783-5p	83.1242	NM_018105
THAP1	hsa-miR-3189-5p	81.5573	NM_018105
THAP1	hsa-miR-4753-3p	81.4478	NM_199003
THAP1	hsa-miR-4696	81.4476	NM_018105
THAP1	hsa-miR-6875-3p	81.0487	NM_018105

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Motifs and transcription factors (TFs) regulating THAP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
THAP1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
THAP1	cisbp__M00968	MTF2 (directAnnotation).
THAP1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
THAP1	cisbp__M00788	ZFY (inferredBy_Orthology).
THAP1	metacluster_175.1	ZNF283 (directAnnotation).
THAP1	metacluster_151.2	ZNF23 (directAnnotation).
THAP1	transfac_pro__M03806	ZBTB7C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
THAP1	metacluster_141.5	down	Malignant cells	GSE175716	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."