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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TGOLN2

Summary for TGOLN2

Gene information	Gene symbol	TGOLN2
	Ensembl ID	ENSG00000152291
	Entrez ID	10618
	Gene name	trans-golgi network protein 2
	Synonyms	TGN38\|TGN46\|TGN48\|TGN51\|TTGN2
	Gene type	protein_coding
	UniProtAcc	O43493

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Dataset with differentially expressed gene: TGOLN2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.300043	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.260458	3.24e-41
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.29573	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.300176	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.253476	3.13e-24
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.295187	1.61e-09
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.578375	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.260422	1.04e-23
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.26802	7.67e-06
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.541676	1.14e-40
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.284675	2.80e-45
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.442846	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.617722	0.00e+00

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Expression of TGOLN2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TGOLN2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TGOLN2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TGOLN2	hsa-miR-320b	94.9558	NM_006464
TGOLN2	hsa-miR-320d	94.9558	NM_006464
TGOLN2	hsa-miR-320c	94.9558	NM_006464
TGOLN2	hsa-miR-320a-3p	94.9558	NM_006464
TGOLN2	hsa-miR-4429	94.9558	NM_006464
TGOLN2	hsa-miR-3622b-5p	92.5258	NM_001206841
TGOLN2	hsa-miR-3619-5p	90.7279	NM_006464
TGOLN2	hsa-miR-761	89.1621	NM_006464
TGOLN2	hsa-miR-4709-3p	88.5992	NM_001206841
TGOLN2	hsa-miR-214-3p	87.8704	NM_006464
TGOLN2	hsa-miR-548q	87.3429	NM_001206841
TGOLN2	hsa-miR-152-3p	84.6773	NM_006464
TGOLN2	hsa-miR-148b-3p	84.6773	NM_006464
TGOLN2	hsa-miR-148a-3p	84.6773	NM_006464
TGOLN2	hsa-miR-3143	84.481	NM_001206841
TGOLN2	hsa-miR-4724-3p	84.4567	NM_001206841
TGOLN2	hsa-miR-4291	84.3543	NM_006464
TGOLN2	hsa-miR-525-5p	81.977	NM_001206844
TGOLN2	hsa-miR-520a-5p	81.977	NM_001206844
TGOLN2	hsa-miR-338-3p	81.9589	NM_001206841
TGOLN2	hsa-miR-302c-5p	80.9201	NM_001206841

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Motifs and transcription factors (TFs) regulating TGOLN2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TGOLN2	jaspar__MA1483.2	ELF2 (directAnnotation).
TGOLN2	hdpi__ETV4	ETV4 (directAnnotation).
TGOLN2	transfac_pro__M04826	EP300 (directAnnotation).
TGOLN2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TGOLN2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
TGOLN2	transfac_pro__M02090	E2F4 (directAnnotation).
TGOLN2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
TGOLN2	cisbp__M07938	E2F1 (directAnnotation).
TGOLN2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
TGOLN2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
TGOLN2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
TGOLN2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
TGOLN2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
TGOLN2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
TGOLN2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TGOLN2	cisbp__M08198	ELF1 (directAnnotation).
TGOLN2	transfac_pro__M00652	NRF1 (directAnnotation).
TGOLN2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
TGOLN2	transfac_pro__M04866	HDAC2 (directAnnotation).
TGOLN2	jaspar__MA1122.1	TFDP1 (directAnnotation).
TGOLN2	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
TGOLN2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
TGOLN2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
TGOLN2	transfac_pro__M01783	SP2 (directAnnotation).
TGOLN2	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
TGOLN2	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
TGOLN2	hdpi__HIP2	UBE2K (directAnnotation).
TGOLN2	transfac_pro__M02913	SP140 (inferredBy_Orthology).
TGOLN2	hdpi__TIMELESS	TIMELESS (directAnnotation).
TGOLN2	transfac_pro__M04893	TAF1 (directAnnotation).
TGOLN2	transfac_pro__M00430	E2F1 (directAnnotation).
TGOLN2	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
TGOLN2	transfac_pro__M00938	E2F1 (directAnnotation).
TGOLN2	transfac_pro__M06404	ZNF497 (directAnnotation).
TGOLN2	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
TGOLN2	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
TGOLN2	hdpi__TP73	TP73 (directAnnotation).
TGOLN2	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
TGOLN2	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
TGOLN2	cisbp__M02645	ETS1 (directAnnotation).
TGOLN2	hdpi__FLI1	FLI1 (directAnnotation).
TGOLN2	taipale_tf_pairs__ETV2_CEBPD_RSCGGANNTTGCGYAAN_CAP_repr	CEBPD; ETV2 (directAnnotation).
TGOLN2	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
TGOLN2	transfac_pro__M01299	MECP2 (directAnnotation).
TGOLN2	transfac_pro__M05697	ZNF235 (directAnnotation).
TGOLN2	jaspar__MA1708.1	ETV7 (directAnnotation).
TGOLN2	metacluster_15.4	SMAD6 (directAnnotation). SMAD6 (inferredBy_Orthology).
TGOLN2	taipale_tf_pairs__GCM1_ETV7_NTNNNGGCGGAAGNNNTTCCNNN_CAP_repr	ETV7; GCM1 (directAnnotation).
TGOLN2	taipale_tf_pairs__HOXB2_ELK1_TAATKRCCGGAAGNN_CAP_repr	ELK1; HOXB2 (directAnnotation).
TGOLN2	jaspar__MA1933.1	SREBF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."