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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TFEC

Summary for TFEC

Gene information	Gene symbol	TFEC
	Ensembl ID	ENSG00000105967
	Entrez ID	22797
	Gene name	transcription factor EC
	Synonyms	bHLHe34\|TCFEC\|TFECL
	Gene type	protein_coding
	UniProtAcc	O14948

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Dataset with differentially expressed gene: TFEC

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.448459	3.89e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.394469	0.00e+00

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Expression of TFEC in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TFEC

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TFEC

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TFEC	hsa-miR-944	98.2751	NM_001244583
TFEC	hsa-miR-3133	97.1073	NM_001018058
TFEC	hsa-miR-4477a	96.6513	NM_001018058
TFEC	hsa-miR-3646	96.4707	NM_001018058
TFEC	hsa-miR-3662	95.173	NM_001244583
TFEC	hsa-miR-297	95.0891	NM_001244583
TFEC	hsa-miR-4778-3p	93.9851	NM_001244583
TFEC	hsa-miR-3148	92.7434	NM_001244583
TFEC	hsa-miR-6832-3p	92.7156	NM_001244583
TFEC	hsa-miR-3658	92.4682	NM_001244583
TFEC	hsa-miR-3163	91.7168	NM_001244583
TFEC	hsa-miR-5696	91.3017	NM_001244583
TFEC	hsa-miR-888-5p	91.2158	NM_001244583
TFEC	hsa-miR-1252-3p	90.5303	NM_001018058
TFEC	hsa-miR-520d-5p	90.1398	NM_001018058
TFEC	hsa-miR-524-5p	90.1398	NM_001018058
TFEC	hsa-miR-548c-3p	89.481	NM_001244583
TFEC	hsa-miR-95-5p	89.4594	NM_001244583
TFEC	hsa-miR-3149	87.9573	NM_001244583
TFEC	hsa-miR-204-5p	87.2252	NM_001244583
TFEC	hsa-miR-211-5p	87.2252	NM_001244583
TFEC	hsa-miR-205-3p	87.1076	NM_001244583
TFEC	hsa-miR-1277-5p	86.2911	NM_001244583
TFEC	hsa-miR-1226-3p	86.1701	NM_001018058
TFEC	hsa-miR-4328	85.9091	NM_001244583
TFEC	hsa-miR-4703-5p	85.5749	NM_001244583
TFEC	hsa-miR-29a-3p	83.6709	NM_001018058
TFEC	hsa-miR-29c-3p	83.6709	NM_001018058
TFEC	hsa-miR-29b-3p	83.6709	NM_001018058
TFEC	hsa-miR-7856-5p	83.5036	NM_001244583
TFEC	hsa-miR-6818-5p	82.7097	NM_001244583
TFEC	hsa-miR-1295b-5p	82.6454	NM_001244583
TFEC	hsa-miR-4795-3p	82.4953	NM_001018058
TFEC	hsa-miR-586	82.4809	NM_001244583
TFEC	hsa-miR-150-3p	82.2965	NM_001244583
TFEC	hsa-miR-607	82.1744	NM_001018058
TFEC	hsa-miR-145-5p	82.0993	NM_001244583
TFEC	hsa-miR-5195-3p	82.0993	NM_001244583
TFEC	hsa-miR-4282	82.0359	NM_001244583
TFEC	hsa-miR-1912-3p	81.9033	NM_001244583
TFEC	hsa-miR-4699-3p	81.6381	NM_001244583
TFEC	hsa-miR-219a-1-3p	81.2369	NM_001244583
TFEC	hsa-miR-4303	81.0352	NM_001244583
TFEC	hsa-miR-3942-5p	80.764	NM_001244583
TFEC	hsa-miR-1282	80.6864	NM_001244583
TFEC	hsa-miR-934	80.6247	NM_001244583

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Motifs and transcription factors (TFs) regulating TFEC

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TFEC	hdpi__FLI1	FLI1 (directAnnotation).
TFEC	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
TFEC	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
TFEC	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
TFEC	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
TFEC	hdpi__TP73	TP73 (directAnnotation).
TFEC	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
TFEC	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
TFEC	transfac_pro__M04748	GABPA (directAnnotation).
TFEC	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
TFEC	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
TFEC	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
TFEC	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
TFEC	transfac_pro__M06032	ZNF727 (directAnnotation).
TFEC	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
TFEC	jaspar__MA1952.1	FOXJ2 (directAnnotation).
TFEC	metacluster_2.6	IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).
TFEC	transfac_pro__M05803	ZNF584 (directAnnotation).
TFEC	tfdimers__MD00138	IRF1; IRF2; IRF3; IRF4; IRF5; IRF7; IRF8; IRF9; MYB (directAnnotation).
TFEC	metacluster_132.4	MEF2B; MEF2B; MEF2B; MEF2B; MEF2C; MEF2C; MEF2D; MEF2D; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF (directAnnotation). SRF; SRF; SRF; SRF (inferredBy_Orthology).
TFEC	metacluster_141.2	E2F2; E2F3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."